Association between Serum Uric Acid Level and Carotid Atherosclerosis in Chinese Individuals Aged 75 Years or Older: A Hospital-Based Case-Control Study

Feng, Lei; Cong, Hua; Sun, Haijie; Qin, Linling; Niu, Peng-Peng; Guo, Zhen‐Ni; Yang, Yi

doi:10.1007/s12603-017-0984-2

Cited by 4 publications

(1 citation statement)

References 27 publications

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“… 9 Increased SUA was associated with the development and progression of atherosclerosis. 10 However, the researches focused on the relationship between SUA and SA was still absent. Furthermore, studies have shown that menopausal women are more likely to develop atherosclerosis, especially prominent in late postmenopausal women.…”

Section: Introductionmentioning

confidence: 99%

Association between serum uric acid and carotid atherosclerosis in elderly postmenopausal women: A hospital‐based study

Dong

Chen

Wang

et al. 2021

Clinical Laboratory Analysis

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Background: Carotid atherosclerosis (CAS) is associated with increased cardiovascular risk and implicated in 20-30% of strokes.Methods: 504 patients were included in this study. The detailed medical history and the results of physical examination, carotid ultrasound examination, and routine laboratory tests were collected. Logistic regression analyses were conducted to analyze the relationship between the SUA and the presence of carotid plaques. And the relationship between SUA and the progression of CAS was analyzed by multiple linear regression. The effect of hormone replacement therapy (HRT) on CAS has also be evaluated.Results: 412 patients (81.7%) had carotid plaques of different sizes by carotid ultrasound examination. We found a positive association between the level of SUA and the probability of having carotid plaque by univariate logistic regression (OR: 2.01, 95% CI: 1.83-2.19, p = 0.003). At 2 years post-discharge, we found that 1 mg/dL increase in SUA levels was expected to 0.946% increase in plaque score and 0.026 cm increase in carotid intima-media thickness, separately. Moreover, patients treated by long-term HRT (≥5 years) had a lower level of SUA and blood lipid and the less change of plaque score and carotid intima-media thickness than patients without HRT. Conclusion:The presence and progression of CAS had significantly positive associations with the level of SUA. And the HRT may have the ability to prevent the presence and progression of CAS. However, the safety and long-term outcome of HRT on CAS should be evaluated in further studies.

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Section: Introductionmentioning

confidence: 99%

Association between serum uric acid and carotid atherosclerosis in elderly postmenopausal women: A hospital‐based study

Dong

Chen

Wang

et al. 2021

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

Metabolic score and its components are associated with carotid plaque prevalence in young adults

Fan,

Yang,

Jia

et al. 2024

Endocrine

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Age and Gender Differences Between Carotid Intima-Media Thickness and Serum Uric Acid

Wang

Zhong

et al. 2022

The American Journal of Cardiology

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Association between Serum Uric Acid Level and Carotid Atherosclerosis in Chinese Individuals Aged 75 Years or Older: A Hospital-Based Case-Control Study

Abstract: The elevated serum uric acid level may be independently and significantly associated with the presence and progression of carotid atherosclerosis in Chinese individuals aged 75 years or older.

Cited by 4 publications

References 27 publications

Association between serum uric acid and carotid atherosclerosis in elderly postmenopausal women: A hospital‐based study

Association between serum uric acid and carotid atherosclerosis in elderly postmenopausal women: A hospital‐based study

Metabolic score and its components are associated with carotid plaque prevalence in young adults

Age and Gender Differences Between Carotid Intima-Media Thickness and Serum Uric Acid

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