Association Between Serum Vitamin D Level and Glaucoma in Women

Arar, Željka Vuković; Praveček, Marijana Knežević; Miškić, Blaženka; Vatavuk, Zoran; Rodríguez, Jadranka Vuković; Sekelj, Sandra

doi:10.20471/acc.2016.55.02.04

Cited by 14 publications

(12 citation statements)

References 21 publications

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“…They found a vertically reversed J-shaped association of serum 25-hydroxyvitamin D with OAG (OR [95% CI]: 1.61 [1.09–2.38] for the lowest quintile compared to the second highest quintile; P-trend [quadratic] = 0.02), with a more pronounced effect in males [ 46 ]. Similarly, two other studies showed lower serum 25-hydroxyvitamin D levels in POAG patients [ 47 , 48 ]. In contrast, the retrospective cross-sectional Kangbuk Samsung health study did not find any difference in total vitamin D levels between patients with and without glaucoma [ 49 ].…”

Section: Resultssupporting

confidence: 53%

The Effect of Vitamins on Glaucoma: A Systematic Review and Meta-Analysis

2018

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Background: The aim of is to determine the association of vitamins with glaucoma by performing a systematic review and meta-analyses. Methods: Studies on the relation of vitamins and glaucoma published up to December 2017 were identified in the PubMed and Embase database. Data on vitamins (method of assessment), glaucoma (type and method of assessment), study characteristics and quality were recorded. In case of multiple studies for one nutrient a meta-analysis was performed. Results: A total of 629 articles were identified of which 36 were included in the systematic review. The meta-analysis included five of them (940 open-angle glaucoma (OAG) cases and 123,697 controls in total) and resulted in an odds ratio [95% confidence interval] (OR [95% CI]) of 0.58 [0.37–0.91] for dietary vitamin A, though heterogeneity was high (I2 = 51%). After omitting studies that contributed significantly to the heterogeneity, the pooled OR [95% CI] was 0.45 [0.30–0.68] for dietary vitamin A on OAG (I2 = 0%). For vitamin B1, C and E no significant association with OAG was found (OR [95% CI]: 0.84 [0.47–1.51]; 0.68 [0.38–1.22]; 0.95 [0.75–1.19]; respectively). However, after addressing heterogeneity, vitamin C showed a protective effect as well. Especially, foods high in these vitamins (e.g., dark green vegetables) were protective for OAG. Conclusions: Dietary intake of vitamin A and C showed a beneficial association with OAG; however, findings on blood levels of vitamins do not show a clear relation with OAG.

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Section: Resultssupporting

confidence: 53%

The Effect of Vitamins on Glaucoma: A Systematic Review and Meta-Analysis

2018

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“…14 Therefore, vitamin D may influence the response of the optic nerve to damage under glaucomatous conditions. However, studies of the association of vitamin D levels with glaucoma are conflicting, with some [15][16][17][18] but not…”

Section: Introductionmentioning

confidence: 99%

Association of Vitamin D with Incident Glaucoma: Findings from the Women's Health Initiative

Carbone

Johnson

Larson

et al. 2021

Journal of Investigative Medicine

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The relationship between vitamin D and glaucoma is controversial. The objective of this study was to examine women from the Women’s Health Initiative (WHI) to determine if there is an association between vitamin D and incident glaucoma in postmenopausal women. We examined the association between dietary vitamin D intake, vitamin D supplements and serum 25 hydroxyvitamin D (25(OH)D) levels and the risk of developing glaucoma. 143,389 postmenopausal women from the WHI including a subset with serum 25(OH) D measurements were examined to determine the association of dietary, supplemental and serum levels of vitamin D to the development of glaucoma. Dietary intakes of vitamin D, use of vitamin D supplements and serum levels of 25(OH) D were predictors examined for the main outcome of incident glaucoma. In multivariable models adjusted for demographic, clinical variables and medication use, dietary vitamin D, vitamin D supplements, total vitamin D intake (diet plus supplements) and serum 25 (OH) D measurements were not significantly associated with incident glaucoma. In the CaD placebo-controlled intervention clinical trial, there was also no association in the active intervention arm with glaucoma. We conclude that dietary vitamin D intake, supplements and serum levels are not significantly related to the risk of developing glaucoma in postmenopausal women.

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“…In a crossover, randomized clinical trial involving 57 glaucoma patients, oral vitamin B 3 supplementation for 6 weeks at 1.5 g/day, then for 6 weeks at 3.0 g/day, improved RGC function, but without affecting the IOP and RNFL thickness [249]. Previous studies have reported that serum vitamin D levels are significantly lower in glaucoma patients as compared to healthy subjects [250,251]. Additionally, the presence of polymorphisms in vitamin D receptors, e.g., the BsmI 'B' allele and TaqI 't' allele, was shown to be a relevant risk factor in the development of POAG [251].…”

Section: Vitaminsmentioning

confidence: 95%

Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

et al. 2022

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Glaucoma is one of the leading causes of irreversible blindness. It is generally caused by increased intraocular pressure, which results in damage of the optic nerve and retinal ganglion cells, ultimately leading to visual field dysfunction. However, even with the use of intraocular pressure-lowering eye drops, the disease still progresses in some patients. In addition to mechanical and vascular dysfunctions of the eye, oxidative stress, neuroinflammation and excitotoxicity have also been implicated in the pathogenesis of glaucoma. Hence, the use of natural products with antioxidant and anti-inflammatory properties may represent an alternative approach for glaucoma treatment. The present review highlights recent preclinical and clinical studies on various natural products shown to possess neuroprotective properties for retinal ganglion cells, which thereby may be effective in the treatment of glaucoma. Intraocular pressure can be reduced by baicalein, forskolin, marijuana, ginsenoside, resveratrol and hesperidin. Alternatively, Ginkgo biloba, Lycium barbarum, Diospyros kaki, Tripterygium wilfordii, saffron, curcumin, caffeine, anthocyanin, coenzyme Q10 and vitamins B3 and D have shown neuroprotective effects on retinal ganglion cells via various mechanisms, especially antioxidant, anti-inflammatory and anti-apoptosis mechanisms. Extensive studies are still required in the future to ensure natural products’ efficacy and safety to serve as an alternative therapy for glaucoma.

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Association Between Serum Vitamin D Level and Glaucoma in Women

Cited by 14 publications

References 21 publications

The Effect of Vitamins on Glaucoma: A Systematic Review and Meta-Analysis

The Effect of Vitamins on Glaucoma: A Systematic Review and Meta-Analysis

Association of Vitamin D with Incident Glaucoma: Findings from the Women's Health Initiative

Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

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