Association between serum YKL-40 level and dysglycemia in cystic fibrosis

Bouvet, Guillaume F.; Maignan, Maxime; Arslanian, Elizabeth; Coriati, Adèle; Rabasa‐Lhoret, Rémi; Berthiaume, Yves

doi:10.1016/j.cyto.2014.10.017

Cited by 10 publications

(2 citation statements)

References 26 publications

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“…In chronic obstructive pulmonary disease, high levels of YKL-40 were shown to correlate with disease severity and overall survival [70,71]. Similar findings were obtained in patients with cystic fibrosis lung disease [72,73]. Additionally, YKL-40 has been suggested as a biomarker for pulmonary sarcoidosis [63], although some studies did not find any correlation with clinical signs on follow-up [74].…”

Section: Chitinase-like Proteinssupporting

confidence: 56%

Perspectives for Monocyte/Macrophage-Based Diagnostics of Chronic Inflammation

Kzhyshkowska¹,

Gudima

Moganti

et al. 2016

Transfus Med Hemother

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Low-grade chronic inflammation underlies the development of the most dangerous cardiometabolic disorders including type 2 diabetes and its vascular complications. In contrast to acute inflammation induced by bacteria and viruses, chronic inflammation can be driven by abnormal reaction to endogenous factors, including Th2 cytokines, metabolic factors like advanced glycation end products (AGEs), modified lipoproteins, or hyperglycemia. The key innate immune cells that recognize these factors in blood circulation are monocytes. Inflammatory programming of monocytes which migrate into tissues can, in turn, result into generation of tissue macrophages with pathological functions. Therefore, determination of the molecular and functional phenotype of circulating monocytes is a very promising diagnostic tool for the identification of hidden inflammation, which can precede the development of the pathology. Here we propose a new test system for the identification of inflammatory programming of monocytes: surface biomarkers and ex vivo functional system. We summarize the current knowledge about surface biomarkers for monocyte subsets, including CD16, CCR2, CX3CR1, CD64, stabilin-1 and CD36, and their association with inflammatory human disorders. Furthermore, we present the design of an ex vivo monocyte-based test system with minimal set of parameters as a potential diagnostic tool for the identification of personalized inflammatory responses.

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Section: Chitinase-like Proteinssupporting

confidence: 56%

Perspectives for Monocyte/Macrophage-Based Diagnostics of Chronic Inflammation

Kzhyshkowska¹,

Gudima

Moganti

et al. 2016

Transfus Med Hemother

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“…In a very large study in Danish population Kjaergaard et al demonstrated that elevated serum YKL-40 level was asssociated with a thirty-four percent increased triglyceride level and a two-fold increased stroke risk, although no genetic YKL-40 elevation were found in these individuals(38). Bouvet et al reported a correlation between elevated serum YKL-40 level and inflammation-induced dysglycemia in a group of patients with cystic fibrosis(39). We excluded subjects with systemic disorders such as hyperlipidemia or diabetes that are regarded as risk factors for coronary artery disease.…”

mentioning

confidence: 99%

A Novel Marker Demonstrating Endothelial Dysfunction in Behçet's Disease, YKL-40

Gündüz¹,

Türkçü²,

Batmaz³

et al. 2016

West Indian Med J

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Background: To evaluate the relationship between disease activity and levels of YKL-40 in patients with Behcet's disease (BD). Methods: Twenty five active and twenty six inactive BD patients and 24 age and gender matched healthy control subjects were included in the study. Serum YKL-40 levels were measured using Enzyme Linked Immuno Sorbent Assay (ng/mL). Disease activity was assessed using Behcet's Disease Current Activity Form (BDCAF). Results: Serum YKL-40 levels were significantly higher in patients with active BD and inactive BD compared to the control group (respectively p<0.001, p< 0.001). There were no significant differences between active and inactive BD groups in terms of levels of YKL-40 (p=0.9). According to Pearson's analysis, YKL-40 levels were significantly positively correlated with Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and skin lesions of BDCAF scores. Conclusion: Our study demonstrated that serumYKL-40 level was significantly higher in active and inactive BD compared to healthy controls. However, the groups with active and inactive disease had no significant difference with respect to YKL-40 level. In addition, there existed a significant correlation between serum YKL-40 level and ESR, CRP, and BDCAF's skin scores.

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