Association between sex hormone-binding globulin (SHBG) and metabolic syndrome among men

Sá, Emmanuela Quental Callou de; Sá, Francisco Carleial Feijó de; Oliveira, Kelly Cristina de; Feres, Fausto; Verreschi, Ieda Therezinha do Nascimento

doi:10.1590/1516-3180.2014.1322666

Cited by 18 publications

(18 citation statements)

References 28 publications

(35 reference statements)

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“…The current study shows that there is no significant difference in serum free testosterone levels between subjects with MetS and non-MetS, which is similar to the findings from other cross-sectional studies [15,16]. Accumulating data have demonstrated that SHBG is more strongly associated with MetS than TT [17,18]. As the score of MetS components increased, the levels of SHBG decreased but SHBG levels were unchanged after addition of five metabolic components.…”

Section: Discussionsupporting

confidence: 90%

Serum Sex Hormone Binding Globulin (SHBG) Relation with Different Components of Metabolic Syndrome in Men with Type 2 Diabetes

et al. 2017

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Sex hormone binding globulin (SHBG) is demonstrated to be decreased in subjects with metabolic syndrome (MetS). The aim of the present study was to investigate the association of SHBG in relation to MetS components among men with type 2 diabetes (T2D). This cross-sectional study was carried out among 429 Saudi T2D male patients aged >30 years. Metabolic syndrome was defined using International Diabetes Federation (IDF) criteria. Fasting blood glucose (FBG), HbA1c, albumin, and lipid parameter were measured. Gonadal hormones, namely total testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and SHBG were determined using ELISA. The SHBG levels of the MetS group was significantly lower than non-MetS group 47.25±31.03 nmol/l vs. 56.55±37.84 nmol/l; p=0.013. As the MetS score increases, SHBG and HDL levels decrease while weight, BMI, waist circumference, SBP, DBP, FBG, HbA1c, TC, and TG levels increase. SHBG correlated with age, BMI, TG, HDL, TT, free testosterone, and bio-available testosterone. This is the first study that provides detailed analyses of SHBG with MetS components in male diabetic subjects. The mean serum SHBG levels gradually declined with the addition of MetS components in T2D men. TT, free testosterone, and bio-available testosterone remained independently associated with SHBG by multivariable regression analysis.

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Section: Discussionsupporting

confidence: 90%

Serum Sex Hormone Binding Globulin (SHBG) Relation with Different Components of Metabolic Syndrome in Men with Type 2 Diabetes

et al. 2017

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“…Some studies suggest that SHBG, as a sex hormonebinding and transport molecule, can better reflect changes in sex hormone levels. 12,14 Similarly, a correlation between sex hormone changes and BPH was also found in rabbits on an HFD diet, and receptors for sex steroids were all increased in the prostates of rabbits fed an HFD, suggesting that in MetS, the sensitivity to changing gonadal hormones is upregulated. 26 This might explain how MetS affects PV through sex hormones.…”

Section: Furthermore As Shown Inmentioning

confidence: 74%

“…In the present study, logistic regression analysis showed that SHBG alone had a weak association with the risk of BPH in the hormone‐adjusted model ( P = .048). Some studies suggest that SHBG, as a sex hormone‐binding and transport molecule, can better reflect changes in sex hormone levels 12,14 . Similarly, a correlation between sex hormone changes and BPH was also found in rabbits on an HFD diet, and receptors for sex steroids were all increased in the prostates of rabbits fed an HFD, suggesting that in MetS, the sensitivity to changing gonadal hormones is upregulated 26 .…”

Section: Discussionmentioning

confidence: 98%

The underlying mechanism of metabolic syndrome on benign prostatic hyperplasia and prostate volume

et al. 2020

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Objective To investigate the potential mechanism of the effect of metabolic syndrome (MetS) on prostate volume (PV) and the risk of benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS) and the relationships of MetS and the major pathogenic factors of MetS with the clinical progression of BPH/LUTS in older Chinese men. Subjects and Methods We analyzed clinical data obtained from 506 ostensibly healthy men who underwent routine health check‐ups and recruited 415 subjects from a group of previously studied men after 4 years. We evaluated the associations of major pathological factors of MetS, including insulin resistance, subclinical inflammatory state, and sex hormone changes, with PV, the risk of BPH and the clinical progression of BPH/LUTS by using multiple linear regression and logistic regression. Results After adjustment for age, insulin, HOMA (homeostatic model assessment) index, leptin, resistin, adiponectin, C‐reactive protein, tumor necrosis factor‐α (TNF‐α), sex hormone‐binding globulin, and testosterone levels were significantly associated with PV (all P < .05), and in the age‐adjusted logistic regression model, positive associations of resistin and TNF‐α with BPH/LUTS were found (OR, 1.662, P = .007 and OR, 1.044, P < .001, respectively). Predictors of BPH/LUTS clinical progression were significantly correlated with MetS and TNF‐α. The group with higher TNF‐α levels had a higher rate of newly diagnosed BPH (9.5% vs 19.1%, P = .006) and a greater increase in PV levels (0.61 ± 0.08 vs 1.09 ± 0.35 cm3, P <.001) after 4 years. Conclusions MetS and its pathological factors were associated with an increased PV and an increased risk of BPH/LUTS that is more prone to clinical progression. TNF‐α may serve as an early biological indicator to identify which patients with BPH/LUTS are at higher risk of unfavorable outcomes.

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“…It controls the transport of sex steroid hormones in the blood circulation to their target tissues 13. Many previous studies have revealed that low levels of serum SHBG are associated with metabolic syndrome, type II diabetes, and cardiovascular disease 45. Nonalcoholic fatty liver disease (NAFLD) grade is also known to be inversely related to serum SHBG levels:67 as the grade of hepatic steatosis increases, serum SHBG level decreases 27.…”

Section: Introductionmentioning

confidence: 99%

Inverse Relationship between Hepatic Steatosis and Alanine Aminotransferase with Sex Hormone-Binding Globulin in Men

et al. 2017

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PurposeSex hormone-binding globulin (SHBG) is a serum glycoprotein produced predominantly in hepatocytes. As such, the synthesis of SHBG could be associated with liver function and metabolic syndrome. Alanine aminotransferase (ALT) levels could reflect hepatocellular injury and insulin resistance; however, the relationship between hepatic steatosis and ALT with SHBG has not been investigated in humans. The objective of this study was to investigate the associations between SHBG and hepatocyte damage among Korean male patients with hepatic steatosis enrolled in a health examination program.Materials and MethodsWe performed a retrospective cross-sectional study with 922 participants who underwent routine health examinations. A total of 922 men with or without hepatic steatosis were divided into three groups. We analyzed the risk of lower serum SHBG levels with or without elevated serum ALT levels using odds ratios with 95% confidence intervals (CIs).ResultsA significantly increased risk of lower serum SHBG level was observed in the group with hepatic steatosis and ALT elevation (95% CI 1.591–4.681).ConclusionIn men with hepatic steatosis, we found that elevated serum ALT levels were associated with lower serum SHBG levels. This finding suggests that subjects with both hepatic steatosis and increased ALT should be considered to have low levels of SHBG.

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Association between sex hormone-binding globulin (SHBG) and metabolic syndrome among men

Cited by 18 publications

References 28 publications

Serum Sex Hormone Binding Globulin (SHBG) Relation with Different Components of Metabolic Syndrome in Men with Type 2 Diabetes

Serum Sex Hormone Binding Globulin (SHBG) Relation with Different Components of Metabolic Syndrome in Men with Type 2 Diabetes

The underlying mechanism of metabolic syndrome on benign prostatic hyperplasia and prostate volume

Inverse Relationship between Hepatic Steatosis and Alanine Aminotransferase with Sex Hormone-Binding Globulin in Men

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