Association Between SHMT1 rs1979277 Polymorphism and Risk of Acute Lymphoblastic Leukemia: A Systematic Review and Meta-analysis

Yang, Qiwen; Zhang, Yan; Yang, Jie

doi:10.1097/mph.0000000000002173

Cited by 2 publications

(4 citation statements)

References 26 publications

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“…55 This change could result in leucineto-phenylalanine amino acid substitution in SHMT1. 55 The SHMT1 C1420T polymorphism can decrease enzyme activity and lead to a reduction in folate levels, Hcy remethylation and DNA synthesis. 56 Studies have shown that SHMT1 1420CT/TT could decrease the risk of acute lymphocytic leukaemia.…”

Section: Serine Hydroxymethyltransferasementioning

confidence: 99%

“…A common single‐nucleotide polymorphism, cytosine (C) to thymus pyrimidine (T), occurs at nucleotide 1420 of the SHMT1 gene (C1420T, rs1979277) 55 . This change could result in leucine‐to‐phenylalanine amino acid substitution in SHMT1 55 . The SHMT1 C1420T polymorphism can decrease enzyme activity and lead to a reduction in folate levels, Hcy re‐methylation and DNA synthesis 56 .…”

Section: Application Of 1c Metabolism In Cancer Immunotherapymentioning

confidence: 99%

“…Thus, SHMT1 and SHMT2 could be regarded as biosynthetic checkpoints for T‐cell growth. A common single‐nucleotide polymorphism, cytosine (C) to thymus pyrimidine (T), occurs at nucleotide 1420 of the SHMT1 gene (C1420T, rs1979277) 55 . This change could result in leucine‐to‐phenylalanine amino acid substitution in SHMT1 55 .…”

Section: Application Of 1c Metabolism In Cancer Immunotherapymentioning

confidence: 99%

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Targeting one‐carbon metabolism for cancer immunotherapy

Ren,

Wang,

Zheng

et al. 2024

Clinical & Translational Med

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BackgroundOne‐carbon (1C) metabolism is a metabolic network that plays essential roles in biological reactions. In 1C metabolism, a series of nutrients are used to fuel metabolic pathways, including nucleotide metabolism, amino acid metabolism, cellular redox defence and epigenetic maintenance. At present, 1C metabolism is considered the hallmark of cancer. The 1C units obtained from the metabolic pathways increase the proliferation rate of cancer cells. In addition, anticancer drugs, such as methotrexate, which target 1C metabolism, have long been used in the clinic. In terms of immunotherapy, 1C metabolism has been used to explore biomarkers connected with immunotherapy response and immune‐related adverse events in patients.MethodsWe collected numerous literatures to explain the roles of one‐carbon metabolism in cancer immunotherapy.ResultsIn this review, we focus on the important pathways in 1C metabolism and the function of 1C metabolism enzymes in cancer immunotherapy. Then, we summarise the inhibitors acting on 1C metabolism and their potential application on cancer immunotherapy. Finally, we provide a viewpoint and conclusion regarding the opportunities and challenges of targeting 1C metabolism for cancer immunotherapy in clinical practicability in the future.ConclusionTargeting one‐carbon metabolism is useful for cancer immunotherapy.

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Section: Serine Hydroxymethyltransferasementioning

confidence: 99%

Section: Application Of 1c Metabolism In Cancer Immunotherapymentioning

confidence: 99%

Section: Application Of 1c Metabolism In Cancer Immunotherapymentioning

confidence: 99%

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Targeting one‐carbon metabolism for cancer immunotherapy

Ren,

Wang,

Zheng

et al. 2024

Clinical & Translational Med

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“…Previous studies have shown that abnormal expression of SHMT1/2 may affect the occurrence and development of HCC by preventing proliferation and migration (13)(14)(15)(16). Although SHMT1 was identi ed as a susceptibility gene for a variety of malignant tumors via genome-wide association analysis (18)(19)(20)(21)(22)(23), the relationship between SHMT1/2 gene polymorphism and HCC susceptibility has not yet been clari ed. Therefore, it is necessary to conduct studies on the association between SHMT1/2 gene polymorphism and HCC susceptibility, which will help to provide an excellent foundation for the researches on the underlying mechanism of SHMT1/2 in HCC susceptibility.…”

Section: Introductionmentioning

confidence: 99%

Interaction Analysis of SHMT1/2 Gene Variants with HCC in Chinese Patients

Sun

Gao

Shi

et al. 2022

Preprint

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Background: Metabolic reprogramming caused by SHMT1/2, as key enzymes in one-carbon metabolism, has been considered to play a critical role in occurrence and progression of hepatocellular carcinoma (HCC). However, the associations between single nucleotide polymorphisms (SNPs) in SHMT1/2 genes and susceptibility of HCC remains unknown. The purpose of this study was to investigate the relation between four candidate SNPs in SHMT1/2 and risk of HCC in Chinese population. Materials and methods: A case-control study including 514 HCC patients and 234 controls was performed to determine associations between SNPs of SHMT1/2 and HCC risk,isolated via mass spectrometry. Results: Our data revealed that SHMT2 rs2229717 was significantly associated with HCC risk when compared to healthy controls under multiple genetic models (Allele T: odds ratio (OR) = 0.73, P=0.023; Dominant Model: OR = 0.72, P=0.044). When our cohort was stratified by sex, male subjects with the T allele and TT genotype for rs2229717 exhibited a decreased risk for HCC risk (OR=0.67, 95%CI=0.50-0.91; OR=0.43, 95%CI=0.18-0.99). In addition, after age stratification was executed, the results showed that both the T allele and the GT genotype for rs2229717 were less common in HCC patients under 50 years old. Conclusion: These data indicate that rs2229717is a predisposing factor for HCC and may affect the occurrence of HCC in various age or sex subgroups, suggesting that SHMT2 rs2229717may be as a useful predictive or diagnostic tool for HCC in some populations.

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Association Between SHMT1 rs1979277 Polymorphism and Risk of Acute Lymphoblastic Leukemia: A Systematic Review and Meta-analysis

Abstract: Objectives: The aim of this study was to explore the potential association the cytosolic serine hydroxy methyltransferase (SHMT1) rs1979277 polymorphism and the risk of acute lymphoblastic leukemia (ALL).

Cited by 2 publications

References 26 publications

Targeting one‐carbon metabolism for cancer immunotherapy

Targeting one‐carbon metabolism for cancer immunotherapy

Interaction Analysis of SHMT1/2 Gene Variants with HCC in Chinese Patients

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