Association between Sleep Duration and Colorectal Adenomas: Findings from a Case–Control Study in Vietnam

Abstract

Background. Colorectal cancer (CRC) is one of the leading cancers worldwide and in Vietnam. Adenomas are important precursors of CRC. Study on the association between sleep duration and development of colorectal adenoma (CRA) is limited, particularly among Vietnamese population. Methods. We conducted an individually matched case-control study of 870 CRA cases and 870 controls in a large-scale colorectal screening program involving 103,542 individuals aged ≥40 years old in Hanoi, Vietnam. Sleep duration was categorized in three groups: short: <6 hours/day, normal: 7-8 hours/day, and long: >8 hours/day. Conditional logistic regression was used to evaluate the association between sleep duration and adenomas risk after controlling for potential confounders. Results. Overall, short-sleep duration was associated with increased risk of having CRA compared to normal duration (Odds Ratio-OR=1.48, 95% confidence interval-CI: 1.12-1.97). This pattern was present in both females (OR=1.58, 95% CI: 1.14-2.18) and males (OR=1.45, 95% CI: 1.08-1.93), with advanced adenomas (OR=1.61, 95% CI: 1.09-2.38) and non-advanced adenomas (OR=1.66, 95% CI: 1.19-2.32). Furthermore, the association between CRA development and short sleep duration was more apparent among females who were non-drinker, non-obese, physically active, with proximal or both sided adenomas and with cardiometabolic disorder. Among males, the short sleep duration was associated with CRA risk among never-smoking, cardiometabolic disorders and obese. Conclusions. Short sleep duration was associated with increased prevalence of both advanced and non-advanced CRAs among Vietnamese population. Impact. Findings from the current study showed that maintaining an adequate sleep duration may have an important implication for CRC prevention and control.