Association between sleep duration, sleep quality and hyperlipidemia in middle-aged and older Chinese: The Dongfeng–Tongji Cohort Study

Abstract

Aims This study aimed to evaluate the relationship between sleep duration, sleep quality and hyperlipidemia in middle-aged and older Chinese. Methods We included 20,712 individuals at baseline from September 2008 to June 2010, and they were followed-up until October 2013. Hyperlipidemia was defined according to the Chinese guidelines on the prevention and treatment of dyslipidemia in adults. Sleep duration was self-reported and sleep quality was evaluated with a questionnaire that was designed according to the Pittsburgh Sleep Quality Index. Logistic regression and Cox proportional hazard models were conducted to explore the associations. Results In the cross-sectional analyses, longer sleep duration (≥10 h) was significantly associated with higher prevalence of hyperlipidemia (odds ratio (OR) = 1.17, 95% confidence interval (CI) = 1.02–1.35) after adjusting for potential confounders. The ORs of hyperlipidemia were significantly elevated among participants with impaired sleep quality (OR = 1.14, 95% CI = 1.08–1.22) and poor sleep quality (OR = 1.20, 95% CI = 1.08–1.34) when compared to those with good sleep quality. In the longitudinal analyses, compared to participants with a sleep duration of 7–<8 h, those with a sleep duration of 9–<10 h (hazard ratio (HR) = 1.19, 95% CI = 1.04–1.35) and ≥10 h (HR = 1.27, 95% CI = 1.02–1.58) showed significantly higher risk of hyperlipidemia after adjusting for potential confounders. However, no statistically significant association was found between impaired or poor sleep quality and hyperlipidemia. Conclusions Longer sleep duration was significantly associated with higher risk of hyperlipidemia. Impaired or poor sleep quality were associated with elevated prevalence of hyperlipidemia, but not with the incidence of hyperlipidemia.

Relationship between sleep duration and sociodemographic characteristics, mental health and chronic diseases in individuals aged from 18 to 85 years old in Guangdong province in China: a population-based cross-sectional study

“…Consideration of anemia has been recommended as part of the clinical evaluation of patients with insomnia. As for hyperlipidemia, long sleep duration has been reported to be associated with higher risk of hyperlipidemia [41], while some studies observed positive association between short sleep duration and high TG or TC levels [42]. In our study, short sleeping habits may predispose individuals to hyperlipidemia risk.…”

Serum uric acid and risk of incident hypercholesterolaemia and hypertriglyceridaemia in middle-aged and older Chinese: a 4-year prospective cohort study

“…Hyperlipidaemia refers to a systemic metabolic disorder in which the concentration of total cholesterol (TC) and triglyceride (TG) in plasma significantly increase due to abnormal fat metabolism or fat transport [1]. Subtypes of hyperlipidaemia include hypercholesterolaemia and hypertriglyceridaemia.…”

Relationship between sleep duration and sociodemographic characteristics, mental health and chronic diseases in individuals aged from 18 to 85 years old in Guangdong province of China: a population-based cross-sectional study

“…[41] Consideration of anemia has been recommended as part of the clinical evaluation of patients with insomnia. As for hyperlipidemia, long sleep duration has been reported to be associated with higher risk of hyperlipidemia, [42] while some studies observed positive association between short sleep duration and high TG or TC levels [43]. In our study, short sleeping habits may predispose individuals to hyperlipidemia risk.…”