Association Between Sleep Quality and Cirrhotic Cardiomyopathy: A Prospective Case-Control Study

Abstract

Objective The main purpose of this study is to evaluate the changes in sleep quality among patients with cirrhotic cardiomyopathy (CCM). Methods The study included liver cirrhosis patients aged 18–75 from Northern Jiangsu People’s Hospital Affiliated to Yangzhou University and collected their clinical examination results to assess the clinical characteristics and related risk factors of patients with CCM. Results The study found that the onset of CCM was not related to the etiology of inducing cirrhosis. Pittsburgh Sleep Quality Index (PSQI) score (odds ratio (OR) = 13.476, 95% confidence interval (CI) = 1.514–119.923, P = 0.020), absolute GLS (OR = 0.328, 95% CI = 0.210–0.510, P < 0.001), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) (OR = 1.050, 95% CI = 1.025–1.076, P < 0.001) were identified as independent risk factors for inducing CCM. Conclusion In patients with CCM, a decrease in sleep quality often occurs. When cirrhotic patients also have poor sleep quality, along with a decrease in absolute Global Left Ventricular Strain (GLS) levels and an increase in NT-proBNP levels, these factors may pose a higher risk for CCM development. However, further validation of these research findings is required in larger sample sizes.