Association between SNCA rs2736990 polymorphism and Parkinson’s disease: a meta-analysis

Fang, Jinni; Hou, Binghui; Liu, Hongxin; Zhang, Xiaona; Wang, Jing; Zhou, Chuanli; Xie, Anmu

doi:10.1016/j.neulet.2017.08.051

Cited by 3 publications

(3 citation statements)

References 31 publications

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“…A large number of studies have shown that the SNCA was most signi cantly associated with sporadic PD. Many previous PD-risk associated meta-analyses [9][10] have focused on the single SNP of SNCA promoter, 5' and 3' end region.…”

Section: Discussionmentioning

confidence: 99%

“…The most studied SNP in SNCA intron is rs2736990 of intron 4. A meta-analysis published in 2017 [10] suggested that the carrier rs2736990(TT/TC) may reduce PD susceptibility, and the results of previous studies are still inconsistent. Above all, it is necessary for us to conduct an in-depth meta-analysis about the association between SNCA intron and PD genetic predisposition involving a large sample.…”

Section: Introductionmentioning

confidence: 99%

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Association between SNCA Intron and genetic predisposition to sporadic Parkinson's disease: a meta-analysis based on 49576 individuals

Yan

et al. 2021

Preprint

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Background The aetiology of Parkinson's disease (PD) is indistinct, but previous studies of different ethnicities have shown that genetic variations in synuclein alpha (SNCA) have an essential character in the risk of PD. The relation between SNCA intronic single nucleotide polymorphisms (SNPs) and the risk of PD is unclear. Based on the general population and five ethnic groups, this article managed a meta-analysis about the connection of SNCA intronic SNPs with the PD genetic predisposition. Methods This study was implemented according to the 24-step guideline, with strict criteria. The analysis was performed using Stata 16.0 software. Five genetic models were used to analyze the strength of the association, which was quantified by OR value and 95% CI. Results We included 15433 cases and 34143 controls from 31 articles. 6 SNPs in the intron region were screened, and 5 SNPs were statistically significant. Three variants augmented the PD susceptibility (rs2736990, rs3822086, and rs3857059), and two SNPs decreased the risk (rs356186 and rs7684318). Subgroup analysis showed that rs2736990 and rs3822086 carriers added the PD genetic predisposition in the East Asian group. European and Latin group carrying rs3857059 and rs2736990 is the high-risk populations of PD. Conclusions This study finally found 5 SNCA intronic SNPs related to the risk of PD. And racial factors should not be ignored.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between SNCA Intron and genetic predisposition to sporadic Parkinson's disease: a meta-analysis based on 49576 individuals

Yan

et al. 2021

Preprint

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“…3,4 The etiology of PD remains unclear. However, genetic factors such as PARK16 , 5 SNCA , 6 or VPS13C variants, 7 as well as certain environmental factors, have been shown to contribute to the increased risk of PD.…”

Section: Introductionmentioning

confidence: 99%

Association between a DJ-1 polymorphism and the risk of Parkinson's disease: a PRISMA-compliant systematic review and meta-analysis

Liu

Zhou

et al. 2020

J Int Med Res

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Objective In recent years, a number of case–control studies have focused on the association between the DJ-1 g.168_185del polymorphism and the risk of Parkinson's disease (PD). However, the results have been conflicting. To estimate the relationship between the DJ-1 g.168_185del polymorphism and PD susceptibility, a comprehensive meta-analysis was performed. Methods Eligible studies concerning the DJ-1 g.168_185del polymorphism and PD susceptibility were searched for in the PubMed, Web of Science, Embase, Wanfang, CNKI, and VIP databases. Odds ratios and 95% confidence intervals were calculated to estimate the strength of the associations. In total, 11 studies were included in this meta-analysis, including 13 case–control studies with 2890 cases and 3043 controls. Results This meta-analysis revealed that DJ-1 g.168_185del variants are associated with PD susceptibility in the non-Asian population, but not in the Asian population. Conclusions Our meta-analysis suggests that DJ-1 gene variants are not associated with the risk of PD in the overall population.

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Investigation of the Relationship Between Parkinson's Disease and Tirap Gene Polymorphism

KIR KAYAN,

ŞAHİN CALAPOĞLU

2024

SDÜ Tıp Fakültesi Dergisi

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Amaç Parkinson hastalığı (PH), beyinde dopamin üreten hücrelerin kaybıyla ilerleyen bir hastalıktır. PH’li hastaların beyin dokularında α-sinüklein adlı bir protein birikir ve nöroinflamasyona neden olur. Nöroinflamasyon, beyindeki bağışıklık sistemi hücrelerinin aktivasyonu ve iltihaplanma ile ilgili moleküllerin salınımını içerir. Bu süreçte rol oynayan Toll Like Reseptör (TLR)’ler patojenleri ve hasarlı hücreleri tanıyarak bağışıklık yanıtını başlatır. Bu çalışmada, TLR sinyal yolağında yer alan bir adaptör protein olan Toll/IL-1 reseptör ilişkili protein (TIRAP) gen bölgesi üzerindeki polimorfik allelin PH’li hastalarda ve kontrol grubunda karşılaştırmalı olarak ilişkisini araştırmayı amaçladık. Gereç ve Yöntem Çalışmaya 39 PH hastası ve 40 sağlıklı kişi katıldı. Katılımcılardan kan örnekleri alınarak DNA izolasyonu yapıldı. TIRAP rs8177374 (975C/T) polimorfizmi PCR ve RFLP yöntemleri ile belirlendi. Bulgular T allel frekansı PH hastalarında 0,218; kontrol grubunda ise 0,200 olarak bulundu. C allel frekansı ve CC genotip frekansı her iki grupta da yüksek bulundu. F değeri PH hastalarında 0,128; kontrol grubunda ise 0,250 olarak bulundu. OR değeri 1,115; CI değeri ise [0,517-2,402] olarak bulundu. Total OR=1,508; P=0,758 olarak bulundu. Sonuç TIRAP polimorfizmi ile PH arasında istatistiksel olarak anlamlı bir ilişki bulunmadı. TIRAP polimorfizminin PH hastalarında risk faktörü olmadığı sonucuna varıldı.

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Association between SNCA rs2736990 polymorphism and Parkinson’s disease: a meta-analysis

Cited by 3 publications

References 31 publications

Association between SNCA Intron and genetic predisposition to sporadic Parkinson's disease: a meta-analysis based on 49576 individuals

Association between SNCA Intron and genetic predisposition to sporadic Parkinson's disease: a meta-analysis based on 49576 individuals

Association between a DJ-1 polymorphism and the risk of Parkinson's disease: a PRISMA-compliant systematic review and meta-analysis

Investigation of the Relationship Between Parkinson's Disease and Tirap Gene Polymorphism

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