Association Between Sodium- and Potassium-Activated Adenosine Triphosphatase α Isoforms and Bipolar Disorders

Goldstein, Inbal; Lerer, Elad; Laiba, Efrat; Mallet, Jacques; Mujaheed, Mustafa; Laurent, Claudine; Rosen, Haim; Ebstein, Richard P.; Lichtstein, David

doi:10.1016/j.biopsych.2008.10.033

Cited by 64 publications

(51 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3 A recent study revealed that genetic variations in Na þ , K þ -ATPase (a major plasma membrane transporter for sodium and potassium) are associated with bipolar disorder, suggesting a role of potassium ion in the etiology of this disease. 35 The other ion channel gene identified in this study is CACNB2, the b-subunit of calcium channel complex. A previous meta-analysis revealed that CAC-NA1C, the a-1 subunit, was strongly associated with bipolar disorder.…”

Section: Discussionmentioning

confidence: 84%

Genome-wide association study of bipolar I disorder in the Han Chinese population

et al. 2010

View full text Add to dashboard Cite

We report the first genome-wide association study in 1000 bipolar I patients and 1000 controls, with a replication of the top hits in another 409 cases and 1000 controls in the Han Chinese population. Four regions with most strongly associated single-nucleotide polymorphisms (SNPs) were detected, of which three were not found in previous GWA studies in the Caucasian populations. Among them, SNPs close to specificity protein 8 (SP8) and ST8 a-Nacetyl-neuraminide a-2,8-sialyltransferase (ST8SIA2) are associated with Bipolar I, with Pvalues of 4.87 Â 10 À7 (rs2709736) and 6.05 Â 10 À6 (rs8040009), respectively. We have also identified SNPs in potassium channel tetramerization domain containing 12 gene (KCTD12) (rs2073831, P = 9.74 Â 10 À6 ) and in CACNB2 (Calcium channel, voltage-dependent, b-2 subunit) gene (rs11013860, P = 5.15 Â 10 À5 ), One SNP nearby the rs1938526 SNP of ANK3 gene and another SNP nearby the SNP rs11720452 in chromosome 3 reported in previous GWA studies also showed suggestive association in this study (P = 6.55 Â 10 À5 and P = 1.48 Â 10 À5 , respectively). This may suggest that there are common and population-specific susceptibility genes for bipolar I disorder.

show abstract

Section: Discussionmentioning

confidence: 84%

Genome-wide association study of bipolar I disorder in the Han Chinese population

et al. 2010

View full text Add to dashboard Cite

show abstract

“…The equations of each target gene amplification were then calculated for optimal experimental condition evaluation. The final absolute copy number of each target gene was calculated by using the formulation of target gene absolute copy numbers = sample concentration/sample molecular weight×6×10 14 , and then was converted to target gene relative copy numbers by using the formulation of target gene relative copy numbers = target gene absolute copy numbers/reference control gene absolute copy numbers. The data were statistically assessed by using Microsoft Excel T-test program.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have also shown that α3 subunit coding gene (ATP1A3) is involved in both unipolar and bipolar depressions and was correlated with the mood changes in depressive disorders [12,13,22], while α2 subunit coding gene (ATP1A2) was significantly associated with bipolar disorder [14] and anxiety-related behavior [15]. However, there is no report about the correlation of α1 subunit coding gene (ATP1A1) with major depressive disorder.…”

Section: Discussionmentioning

confidence: 99%

“…Genome-wide gene expression analysis by using either DNA microarray [10] or whole genome cRNA microarray [11] found that more than 100 genes were related to major depressive disorder. Other studies also showed that the decreased expression level of ATP1A3 gene that codes for the α3 subunit isoform might play an important role in major depressive disorder [12,13], while the ATP1A2 gene that codes for the α2 subunit isoform has a significant association with bipolar disorder [14] and anxiety-related behavior [15]. However, there is no report about the potential gene expression level change of ATP1A1 that codes for the most abundant α1 subunit isoform in the cerebrum in major depressive disorder patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Decreased Na+/K+ ATPase α1 (ATP1A1) gene expression in major depression patients’ peripheral blood

Qian

et al. 2013

Open Life Sciences

View full text Add to dashboard Cite

Major depression affects the central nervous system and thereafter the autonomic nervous system, immune system, and endocrine system. Na+/K+ ATPase, as a major mediator of cellular transmembrane ionic gradients, plays an important role in nervous signal transduction. Three types of Na+/K+ ATPase α subunit isoforms (ATP1A1, ATP1A2, and ATP1A3) are found in brain but vary in the type of cell and level of expression. It has been confirmed that reduced expression of ATP1A2 and ATP1A3 are related to depressive disorder. However, there is no reported correlation between ATP1A1 and major depression. This study investigated the potential correlation between ATP1A1 gene expression level and major depression. The expression levels of ATP1A1 gene in the peripheral circulation of both depressive patients and healthy human controls were quantified by using reverse transcripted quantitative polymerase chain reaction. Statistical analysis showed a significant decrease of ATP1A1 expression level in major depression patients when compared to that of healthy controls (P<0.01). The differences of gene nucleotide sequences and protein structures among ATP1A1, ATP1A2, and ATP1A3 were also illustrated. This study demonstrates, for the first time, that ATP1A1 gene expression level is significantly associated with major depression and suggests that ATP1A1 could be a significant molecular marker for diagnosis.

show abstract

“…This can result in low hemoglobin (Hb) counts and anemia 1,2 . Thalassemia is a genetic disorder of hemoglobin production, in which there is a partial or complete failure to synthesize specific type of globins This genetic disorder is found in people living along the shores of the Mediterranean and in the Middle Eastern and Asian Countries 3,4 . An important structural abnormality of the Hb chain is sickle cell hemoglobin (Hb S).…”

Section: Introductionmentioning

confidence: 99%

The sensitivity of Na<sup>+</sup>, K<sup>+</sup> ATPase as an indicator of blood diseases

et al. 2017

View full text Add to dashboard Cite

show abstract

Association Between Sodium- and Potassium-Activated Adenosine Triphosphatase α Isoforms and Bipolar Disorders

Cited by 64 publications

References 45 publications

Genome-wide association study of bipolar I disorder in the Han Chinese population

Genome-wide association study of bipolar I disorder in the Han Chinese population

Decreased Na+/K+ ATPase α1 (ATP1A1) gene expression in major depression patients’ peripheral blood

The sensitivity of Na<sup>+</sup>, K<sup>+</sup> ATPase as an indicator of blood diseases

Contact Info

Product

Resources

About