Association Between Spesific Enolase Serum Levels and Outcome Acute Ischemic Stroke Onset 1-Month

Abstract

Pendahuluan: Stroke adalah masalah kesehatan global, karena penyebab kematian kedua dan kecacatan utama pada hampir seluruh negara di dunia. Penyakit ini memiliki dampak yang besar terhadap penderita, lingkungan sosial dan beban ekonomi. Sehingga diperlukan penanda spesifik yang berperan dalam menegakkan diagnosis, penentuan faktor risiko, serta tingkat keparahan stroke iskemik. Salah satu penanda yang diteliti adalah kadar NSE serum, yang diperkirakan dapat menggambarkan beratnya kerusakan otak pada pasien stroke.Metode: Penelitian ini menggunakan metode Cross sectional study pada 77 pasien stroke iskemik , dilaksanakan mulai Juli 2016 sampai Agustus 2017, di ruang rawat inap di Bagian Penyakit Saraf RS. DR. M. Djamil Padang. Setiap pasien dilakukan pemeriksaan kadar NSE serum dan penilaian skor mRS pada bulan-1 setelah onset stroke iskemik. Dan dilakukan uji Spearmen untuk menilai korelasi antara dua variabel. Nilai p <0.05 dianggap signifikan secara statistikHasil: Berdasarkan jenis kelamin didapatkan laki-laki 42 orang (54.54%). Median usia 58.21 (16-88). Median kadar NSE 5.94 ( 2.77-36.75) µg/L. Skor mRS onset bulan-1 dengan median 3 (1-6). Terdapat hubungan antara kadar serum NSE dengan fungsi luaran stroke iskemik onset bulan-1 (r = 0.286, p value= 0.012, R2= +8.2%)Diskusi: Terdapat hubungan antara kadar serum NSE dengan fungsi luaran stroke iskemik onset bulan-1.Kesimpulan: Terdapat hubungan antara kadar serum NSE dengan fungsi luaran stroke iskemik onset bulan-1.

Diagnostic Value of Serum Neuron-Specific Enolase Level in Patients With Acute Ischemic Stroke; A Systematic Review and Meta-Analysis

“…In terms of functional outcomes, included studies used different methods to assess functional outcomes such as Barthel index, Lindley scale, modified Rankin Scale (mRS), Glasgow Outcome Score, and activities of daily living scale. Three studies 22,32,35 reported a notable correlation between NSE and functional outcome. Moreover, Pandey et al, 14 and Bharosay et al 25 concluded that the higher the NSE level, the more significant functional worsening.…”

“…These results are consistent with the findings of nine out of the 12 included studies in the current meta-analysis, which showed that NSE levels were meaningfully higher in stroke patients than in the control group while, other three included studies showed no significant difference between NSE and control. 28,34,35 This contrast might be explained by the slow released of NSE from damaged tissue to peripheral blood.…”

Effect of erythropoietin administration on expression of mRNA brain-derived Neutrophic factor, levels of stromal cell-derived Factor-1, and neuron specific enolase in brain injury model Sprague Dawley

“…NSE with its longer half-life in blood compared to other biomarkers, can indicate the presence of brain inflammatory processes and neuronal cell death. High levels of NSE are associated with neuronal cell injury [ 16 ].…”