2020
DOI: 10.1136/bmjopen-2020-044421
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Association between statin use and outcomes in patients with coronavirus disease 2019 (COVID-19): a nationwide cohort study

Abstract: ObjectiveTo investigate the association between recent statin exposure and risk of severe COVID-19 infection and all-cause mortality in patients with COVID-19 in Denmark.Design and settingObservational cohort study using data from Danish nationwide registries.ParticipantsPatients diagnosed with COVID-19 from 22 February 2020 to 17 May 2020 were followed from date of diagnosis until outcome of interest, death or 17 May 2020.InterventionsUse of statins, defined as a redeemed drug prescription in the 6 months pri… Show more

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Cited by 61 publications
(71 citation statements)
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“…The composition of our cohort was similar to other published patient databases of patients with COVID-19 (17, 22, 24). The median age of patients was 60 years old (IQR 47-73 years).…”
Section: Discussionsupporting
confidence: 62%
See 1 more Smart Citation
“…The composition of our cohort was similar to other published patient databases of patients with COVID-19 (17, 22, 24). The median age of patients was 60 years old (IQR 47-73 years).…”
Section: Discussionsupporting
confidence: 62%
“…Observational studies have similarly yielded mixed results regarding the effects of statins in COVID-19. These investigations have been limited by small sample size (16-19), insufficient adjustments for time varying confounders (16, 20, 21), and lack of a sub-cohort newly initiated on statins for COVID-19 (20, 22-24).…”
Section: Introductionmentioning
confidence: 99%
“…We further examined 26 full-text articles and searched the references of relevant articles, retrieving 2 additional publications. Finally, 22 studies met all inclusion criteria [ 1 , 9 , 10 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. The flow diagram of the systematic articles search is presented in Figure 1 .…”
Section: Resultsmentioning
confidence: 99%
“…3-hydroxy-3-methyl-glutayl-CoA (HMG-CoA) reductase inhibitors, statins, are the most widely prescribed medication for the treatment of cardiovascular disease, including stroke, hyperlipidemia, and myocardial infarction [ 6 , 7 , 8 ]. Recently, epidemiological studies have highlighted the association between the statin and the reduced risk of severity and mortality among COVID-19 patients [ 9 , 10 ]. Statin can reduce the rate of mortality in various ways, like increasing vascular endothelial function [ 11 ], blocking miR-133a expression [ 12 ], reducing acute-phase proteins level (like C-reactive protein) [ 13 ], and anti-inflammatory effects [ 14 ].…”
Section: Introductionmentioning
confidence: 99%
“…While potentially relevant, we did not explore past medication data in our analyses because the available EHR data did not provide comprehensive medication coverage but predominantly medication orders and administrations for hospitalized patients. Other population-based cohorts with prescription registries, as exemplified by Butt and colleagues [ 36 ], might be better suited for such an exploration.…”
Section: Discussionmentioning
confidence: 99%