Association Between Systemic and Local Oxidative Stress of Infertile Women Undergoing Ivf/Icsi

Mahdi, Qais Ahmed; Wadood, Shatha Abdul; Hamza, Rusul H

doi:10.24996/ijs.2019.60.9.1

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…Oxidative stress (OS) arises from a perturbation in the equilibrium between the generation of Reactive Oxygen Species (ROS) and the protective mechanisms provided by antioxidant defense systems. The depletion of antioxidants takes place, leading to dysfunction and harm at the cellular level [10]. The occurrence of oxidative stress in the lungs as a result of nicotine exposure has been documented in many rat models Cell membrane damage is a consequence of lipid peroxidation resulting from heightened oxidative stress, [11] [12].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Sodium Thiosulfate and Resveratrol in Remodeling Lung Injury and Expression of BCL2 in Nicotine-Stressed Rats

Al-Tamemi,

Al-Okaily

2024

UPJOZ

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Background and Objective: Nicotine is linked to the development of several illnesses, including cancer The current study aimed to assess the ability of sodium thiosulfate (STS) to decrease the harmful effects of nicotine in lungs and gene expression of Bcl2 gene in rats and compare them with resveratrol (RES) supplement. Methods: Thirty-six male rats, Rattus norvegicus (weighing 190–220 g) were chosen randomly and separated into six equal groups. Animals in the control group were administered an intraperitoneal injection of normal saline, while those in group G1 were injected (I/P) with nicotine (1.5 mg/kg b.wt.). G2: were injected I/P with STS (450 mg/kg b.wt) and nicotine (1.5 mg/kg b.wt). G3: rats were gavaged with resveratrol supplement (87 mg/kg b.wt) and (I/P) injected with nicotine at the same dose. G4 group were (I/P) injected with STS (450 mg/kg b.wt) and administered (RES) (87 mg/kg b.wt) plus injected with nicotine (1.5 mg/kg b.wt). I/P injections of STS (450 mg/kg b.wt) and Resveratrol (87 mg/kg body weight) were given to group G5. All groups were administered for 28 days, after 24 hours after the last administration, all animals were sacrificed, and tissue specimens were collected from the lung for histopathological changes and for gene expression analysis of Bcl2. Results: The results of Lung sections for G1 showed severe peribronchiolar and perivascular lymphocytic cuffs, congestion, pulmonary emphysema, cuboidal metaplasia of the bronchiolar epithelium, granulomatous inflammation, thickening in the alveolar walls, and severe hemorrhage with hemosiderosis as compared with other experimental groups while group G2 showed that STS attenuating the effect of nicotine on lung tissue characterized by normal bronchioles which lined by normal columnar epithelium with scattered macrophages slight perivascular lymphocytic cuffs, a few desquamations of the bronchiolar epithelium, G3 group which administered RES showed that some alveoli had thickened walls; others showed slightly distended walls, few infiltrations of macrophages and lymphocytes, and desquamation of the bronchiolar epithelium. Moreover sections of lungs for G4 that administered both STS and RES with nicotine showed that most alveoli were normal, with slight thickening in their walls and slight blood vessel congestion. Furthermore, results represented a significant decrease in expression of the BCl2 gene for G1 compared with other groups. In contrast, a significant increase in the fold change of the BCL2 gene was observed in the G2, G3, G4, and G5 groups, indicating the protective effects of RES and STS on histopathological sections and fold change for the BCL2 gene against nicotine-stressed rats. Conclusion: Rats who received STS showed more effectiveness in modulating the bad effects of nicotine than those who received RES, which can give an idea that STS is more effective as an antioxidant than RES.

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Section: Introductionmentioning

confidence: 99%

Effectiveness of Sodium Thiosulfate and Resveratrol in Remodeling Lung Injury and Expression of BCL2 in Nicotine-Stressed Rats

Al-Tamemi,

Al-Okaily

2024

UPJOZ

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“…There is much infertility management that helps to solve the problem by either hormonal treatment or Assisted Reproductive Techniques (ART) such as Intra-Uterine Insemination (IUI), In Vitro Fertilization (IVF) and Intra-Cytoplasmic Sperm Injection (ICSI) (3) .…”

Section: Introductionmentioning

confidence: 99%

Study the Level of the Pregnancy Associated Plasma Protein-A (PAPP-A) Isolated from Mature Retrieved Oocyte during ICSI Protocol in Iraqi Infertile women

Yousif¹,

Salih²

2023

The Egyptian Journal of Hospital Medicine

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Background: The total number of oocytes, oocyte maturation, and oocyte fertilization all significantly affect how successful in vitro fertilization (IVF) is. Additionally, it has been demonstrated that several chemicals in follicular fluid, including cytokines and growth factors, have a major impact on follicular maturation, ovulation, and follicular atresia. One of these molecules, Pregnancy Associated Plasma Protein-A (PAPP-A), a part of the Insulin like Growth Factor (IGF) pathway, has been demonstrated to be generated by granulosa cells and present in follicular fluid. Objective: The aim of this study is to measure the level of Pregnancy Associated Plasma Protein-A (PAPP-A) in Follicular Fluid (FF) of infertile women undergoing ICSI, and to looking into the connections of PAPP-A with some reproductive hormones level. Patients and methods: The study included infertile women from Al-

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How phytochemicals influence reproductive outcomes in women receiving assisted reproductive techniques: a systematic review

Kircali-Haznedar,

Mumusoglu,

Bilgic

2024

Nutrition Reviews

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Context Over the past few years, there has been an increasing amount of scholarly literature suggesting a connection between the nutritional status of pregnant mothers and early fetal development, as well as the long-term health consequences of their offspring. Multiple studies have documented that alterations in dietary patterns prior to conception have the potential to affect the initial stages of embryonic development. Objectives The aim of this study was to perform a comprehensive review of the research pertaining to the correlation between phytochemicals ( specifically, polyphenols, carotenoids and phytoestrogens) and assisted reproductive technology (ART). Data sources PubMed, Scopus, Web of Science, and Clinical Trials databases were searched from January 1978 to March 2023. Study Selection This study comprised observational, randomized controlled, and cohort studies that examined the effects of phytochemicals on ART results. The study's outcomes encompass live birth rate, clinical pregnancy, and ongoing pregnancy. Data extraction The assessment of study quality was conducted by 2 researchers, independently, using the Quality Criteria Checklist for Primary Research. Results A total of 13 studies were included, of which there were 5 randomized controlled studies, 1 nonrandomized controlled study, 6 prospective cohort studies, and 1 retrospective cohort study. Conclusion This research focused on investigating the impact of phytochemicals on ART and has highlighted a dearth of articles addressing that topic. Collaboration among patients, physicians, and nutritionists is crucial for doing novel research. Systematic Review Registration PROSPERO registration no. CRD42023426332.

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Association Between Systemic and Local Oxidative Stress of Infertile Women Undergoing Ivf/Icsi

Cited by 5 publications

References 33 publications

Effectiveness of Sodium Thiosulfate and Resveratrol in Remodeling Lung Injury and Expression of BCL2 in Nicotine-Stressed Rats

Effectiveness of Sodium Thiosulfate and Resveratrol in Remodeling Lung Injury and Expression of BCL2 in Nicotine-Stressed Rats

Study the Level of the Pregnancy Associated Plasma Protein-A (PAPP-A) Isolated from Mature Retrieved Oocyte during ICSI Protocol in Iraqi Infertile women

How phytochemicals influence reproductive outcomes in women receiving assisted reproductive techniques: a systematic review

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