Association between systemic arterial stiffness and age-related macular degeneration

Satô, Eiichi; Feke, Gilbert T.; Appelbaum, E.Y.; Menke, Marcel N.; Trempe, Clement L.; McMeel, J. Wallace

doi:10.1007/s00417-005-0201-6

Cited by 28 publications

(22 citation statements)

References 45 publications

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“…Type VIII collagen is involved in VSMC migration, differentiation, and morphogenesis and is upregulated after vascular injury, [23][24][25] Collagen type VIII is moreover related to arterial stiffness in an animal model, 26 and polymorphisms in the COL8A1 gene are associated with age-related macular degeneration, a condition known to correlate with measures of arterial stiffness. [27][28][29] Collagen α-1 (IV) is abundantly present in the vascular wall, where it is the main component of basement membranes. 22 Its role in the vasculature is not well defined; however, it is interesting that a genome-wide association study of 4221 individuals found that a polymorphism in COL4A1 was highly significantly associated with PWV 30 and that an experimental study has found that mice with COL4A1 missense mutations display defects in several vascular functions and show low blood pressure.…”

Section: Discussionmentioning

confidence: 99%

Proteome Analysis of Human Arterial Tissue Discloses Associations Between the Vascular Content of Small Leucine-Rich Repeat Proteoglycans and Pulse Wave Velocity

Hansen

Beck

Irmukhamedov

et al. 2015

ATVB

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Objectives-We hypothesized that arterial stiffness is associated with changes in the arterial protein profile, particularly of extracellular matrix components. We aimed at determining differentially expressed proteins by quantitative proteome analysis in arterial tissue from patients with different degrees of arterial stiffness. Approach and Results-Arterial stiffness, assessed by carotid-femoral pulse wave velocity (PWV), central blood pressure and augmentation index by pulse wave analysis were measured the day before surgery in a group of patients undergoing coronary artery bypass grafting. Protein extracts of well-defined, homogenous, nonatherosclerotic individual samples of the left mammary artery from 10 of these patients with high PWV and 9 with low PWV were compared by quantitative proteome analysis, using tandem mass tag labeling and nano-liquid chromatography mass spectrometry/mass spectrometry. Of 418 quantified proteins, 28 were differentially expressed between the groups with high and low PWV (P<0.05). Three of 7 members of the extracellular matrix family of small leucine-rich repeat proteoglycans displayed significant differences between the 2 groups (P=0.0079; Fisher exact test). Three other ECM proteins were differentially regulated, that is, collagen, type VIII, α-1 and α-2 and collagen, type IV, α-1. Several proteins related to smooth muscle cell function and structure were also found in different amounts between the 2 groups. Conclusions-Changes in the arterial amounts of small leucine-rich proteoglycans, known to be involved in collagen fibrillogenesis, and of some nonfibrillar collagens in combination with alterations in proteins related to functions of the human arterial smooth muscle are associated with arterial stiffness, as determined by PWV. fibril organization and fibrillogenesis. 8 Mice knockout models for SLRPs display disorganized collagen fibril network and loses functions of the connective tissue and present with different disorders related to abnormal collagen fibril sizes and network, such as aortic dissection and rupture, skin fragility, joint laxity, and tendon weakness. 9,10 In this study, we hypothesized that patients with a high degree of arterial stiffness display a specific protein expression pattern different from patients with a normal low degree of arterial stiffness. We applied a quantitative proteomic approach to identify differentially expressed proteins in individual arterial tissue samples obtained from patients with high and low PWV. We investigate the internal mammary artery because this vessel has proven to be a suitable model artery for studies of generalized nonatherosclerotic arterial changes, that is, its matrix composition, endothelial function, and biochemistry reflect alterations in both the coronary and carotid arteries, as well as other features related to the arterial system. 11-13 MethodsMaterials and Methods are available in the online-only Data Supplement. ResultsBaseline patient characteristics are summarized in Table 1. There were no statistical d...

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Section: Discussionmentioning

confidence: 99%

Proteome Analysis of Human Arterial Tissue Discloses Associations Between the Vascular Content of Small Leucine-Rich Repeat Proteoglycans and Pulse Wave Velocity

Hansen

Beck

Irmukhamedov

et al. 2015

ATVB

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“…Aortic distensibility and PWV reflect aortic elastic properties which are linked to increased cardiovascular morbidity and mortality in different diseases such as atherosclerosis, hypertension, and diabetes mellitus [11][12][13][14]. Some studies have reported an association between increased AS and diseases like age-related macular degeneration, retinal arterial narrowing and BRVO [15][16][17]. In the present study, we aimed to determine whether AS in different segments of the arterial tree is increased in patients with BRVO.…”

Section: Introductionmentioning

confidence: 94%

Impaired aortic stiffness and pulse wave velocity in patients with branch retinal vein occlusion

Kaderli

Güllülü

et al. 2010

Graefes Arch Clin Exp Ophthalmol

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The results of this study show that the arterial stiffness indices (large arterial elasticity index and aortic distensibility) are abnormal in patients with BRVO compared to the healthy and hypertensive controls. Arterial stiffness may play a role in the onset or progression of BRVO. Further studies are needed to determine the exact role of AS in the pathogenesis of BRVO, and to reveal its value in predicting systemic morbidity and mortality in patients with BRVO.

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“…The results of the current study are the first to show that a proper level of aortic stiffness is related to the development of exudative AMD. The pulse wave velocity (PWV) has also been reported to be a parameter of arterial stiffness 24,25) , and a relationship between AMD and the PWV has been documented 26) . However, the PWV is dependent on the blood pressure at the time of measurement 16) .…”

Section: Discussionmentioning

confidence: 99%

Cardio-Ankle Vascular Index Elevation in Patients with Exudative Age-Related Macular Degeneration

Taniguchi

Shiba

Takahashi

et al. 2013

JAT

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Aim:To clarify whether the cardio-ankle vascular index (CAVI) independently contributes to the development of exudative age-related macular degeneration (AMD) compared with carotid arteriosclerosis parameters and other risk factors. Methods: Eighty-eight consecutive patients with exudative AMD were enrolled. A control group (40 age-matched men, 65 years of age or older) was also evaluated, and the parameters were compared between the two groups. A logistic regression analysis was used to determine independent factors for the diagnosis of AMD. In addition, simple linear and multiple regression analyses were used to determine the relationships between the CAVI and other parameters.

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Association between systemic arterial stiffness and age-related macular degeneration

Abstract: Patients with AMD have increased systemic arterial stiffness compared with age-matched controls. Treatments aimed at preventing or reversing systemic arterial stiffness may also be effective in preventing the onset or slowing the progression of AMD.

Cited by 28 publications

References 45 publications

Proteome Analysis of Human Arterial Tissue Discloses Associations Between the Vascular Content of Small Leucine-Rich Repeat Proteoglycans and Pulse Wave Velocity

Proteome Analysis of Human Arterial Tissue Discloses Associations Between the Vascular Content of Small Leucine-Rich Repeat Proteoglycans and Pulse Wave Velocity

Impaired aortic stiffness and pulse wave velocity in patients with branch retinal vein occlusion

Cardio-Ankle Vascular Index Elevation in Patients with Exudative Age-Related Macular Degeneration

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