Association Between TCF21 Gene Polymorphism with the Incidence of Paroxysmal Atrial Fibrillation and the Efficacy of Radiofrequency Ablation for Patients with Paroxysmal Atrial Fibrillation

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia with a high rate of recurrence after catheter ablation. The gene encoding transcription factor 21 (TCF21) has been linked to coronary artery disease risk by human genome-wide association studies in multiple racial ethnic groups. However, the association of TCF21 with AF remains unclear. Patients and Methods: Circulating leukocytes in patients with paroxysmal AF (PAF) and 92 age-matched controls without a history of cardiovascular disease, AF and other arrhythmias were collected. A total of 224 PAF patients receiving radiofrequency ablation had an 18-month scheduled follow-up study for recurrence of AF. Three single-nucleotide polymorphisms (SNPs) of TCF21 (rs2327429, rs2327433 and rs12190287) were genotyped by PCR, and serum levels of TCF21 were measured by ELISA. Results: More males and smokers were observed in the PAF group compared with controls. C allele of rs2327429, G allele and GG genotype of rs12190287 were markedly associated with the increased onset of PAF. The levels of serum TCF21 were significantly higher in PAF group than those in control group (1.96 ± 0.85 vs 0.86 ± 0.49 ng/mL, P<0.001). Based on logistic regression analysis, we confirmed that risk allele at rs12190287 and serum TCF21 concentration were independently correlated with the incidence of PAF. Furthermore, GG genotype of rs12190287 enhanced the susceptibility of AF recurrence after ablation. Conclusion: G allele and GG genotype of rs12190287 in TCF21 and elevated TCF21 concentration are significantly associated with the onset of PAF and recurrence after ablation.

Transcription Factor 21: A Transcription Factor That Plays an Important Role in Cardiovascular Disease

“…In a recent study, it was found that the G allele and GG genotype of rs12190287 in TCF21 and the increase of TCF21 concentration were significantly associated with the occurrence of PAF and recurrence after ablation. TCF21 rs12190287 polymorphism can regulate the expression of TCF21, and the G allele and GG genotype of rs12190287 are associated with the pathogenesis and recurrence of PAF [95]. This suggests that TCF21 rs12190287 polymorphism may be a potential marker of genetic susceptibility to PAF onset and recurrence after catheter ablation in the Chinese population.…”

Transcription factor 21 rs12190287 polymorphism is related to stable angina and ST elevation myocardial infarction in a Chinese Population

“…Moreover, a Japanese study reported that TCF21 rs12190287 (G→C) may be a susceptibility locus for hypertension [24]. Another study found significant associations between the GG genotype and G allele of rs12190287 in TCF21 and an increased TCF21 concentration with the onset and recurrence of paroxysmal atrial fibrillation post ablation [25]. Considering these findings, study aimed to further explore whether TCF21 genetic polymorphisms affected susceptibility to stable angina and ST elevation myocardial infarction (STEMI) and their relationships with clinical and biochemical characteristics.…”

Genome-wide association studies reveal differences in genetic susceptibility between single events versus recurrent events of atrial fibrillation and myocardial infarction: the HUNT study

“…While many variants have been identified and replicated in other studies, these variants were identified when comparing all included cases of AF or MI with healthy controls. Some studies have been conducted with the aim of understanding the genetic of patients experiencing recurrent events of AF (1, 7, 8, 9, 10) and MI (11, 12, 13). These are, however, mostly focused on either (A) response after treatment, or (B) the genetic effects on recurrence from known AF/MI variants or genes.…”