Association between Telomere Length and Type 2 Diabetes Mellitus: A Meta-Analysis

Zhao, Jinzhao; Miao, Kun; Wang, Haoran; Ding, Hu; Wang, Dao Wen

doi:10.1371/journal.pone.0079993

Cited by 189 publications

(167 citation statements)

References 32 publications

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“…The associations between telomeres, diseases, physiological aging, and decline in physical functioning are ambiguous. Telomere length has shown a modest association with several risk factors (Haycock et al 2014;Willeit et al 2014) and various chronic diseases (Zhao et al 2013;Haycock et al 2014;Albrecht et al 2014). Shortened telomeres can result in cell cycle arrest, tumor suppression, and loss of functional tissue via senescence or apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have already shown that LTL is inversely associated with mortality (Cawthon et al 2003) and several age-related diseases such as cardiovascular diseases, COPD, cancer, and type 2 diabetes (Zhao et al 2013;Haycock et al 2014;Albrecht et al 2014). The evidence on the association between LTL and physical functioning is inconclusive.…”

Section: Introductionmentioning

confidence: 99%

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Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?

Sillanpää

Törmäkangas

Rantanen

et al. 2016

AGE

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Leukocyte telomere length (LTL) is known to be associated with mortality, but its association with age-related decline in physical functioning and the development of disability is less clear. This study examined the associations between LTL and physical functioning, and investigated whether LTL predicts level of physical functioning over an 11-year follow-up. Older mono-(MZ) and dizygotic (DZ) twin sisters (n = 386) participated in the study. Relative LTL was measured by qPCR at baseline. Physical functioning was measured by 6-min walking distance and level of physical activity (PA). Walking distance was measured at baseline and at 3-year follow-up. PA was assessed by questionnaire at baseline and at 3-and 11-year follow-ups. The baseline analysis was performed with path models, adjusted with age and within-pair dependence of twin pairs. The longitudinal analysis was performed with a repeated measures linear model adjusted for age and longitudinal within-pair dependence. A nonrandom missing data analysis was utilized. At baseline, in all individuals, LTL was associated with PA (est. 0.14, SE 0.06, p = 0.011), but not with walking distance. Over the follow-up, a borderline significant association was observed between LTL and walking distance (est. 0.14, SE 0.07, p = 0.060) and a significant association between LTL and PA (est. 0.19, SE 0.06, p = 0.001). The results suggest that LTL is associated with PA and may, therefore, serve as a biomarker predicting the development of disability. Longitudinal associations between LTL and PA were observed only when nonrandom data missingness was taken into account in the analysis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?

Sillanpää

Törmäkangas

Rantanen

et al. 2016

AGE

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“…Así pues, estos factores son los que están implicados con enfermedades de muy diferente espectro que están relacionadas con los telómeros (48)(49)(50). Entre estas enfermedades están las ligadas al envejecimiento: enfermedades de tipo cardiovascular (infarto de miocardio, enfermedad cerebrovascular, enfermedad arterial periférica) (27,36), cirrosis hepática, hipertensión, aterosclerosis, diabetes, cáncer y enfermedades neurodegenerativas (alzhéimer, párkinson) (14,(51)(52)(53)(54). La longitud de los telómeros predice la mortalidad y las enfermedades relacionadas con el envejecimiento (49).…”

Section: Introductionunclassified

Telómeros Y Calidad De La Dieta: Una Revision Sistematica

Marti¹,

Echeverría

Morell‐Azanza

et al. 2017

Nutr Hosp

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Palabras clave:Telómeros. Dieta mediterránea. Estrés oxidative. ADN. ResumenFundamento: existen pocos estudios que hayan evaluado la relación entre la calidad de la dieta y la integridad telómerica en humanos. Los telómeros son regiones de ADN no codificante que se encuentran en los extremos de los cromosomas, cuya longitud además de indicar la esperanza de vida, indica el estado global de salud. El objetivo de la presente revisión sistemática es recopilar la evidencia existente sobre la relación entre la longitud de los telómeros y la calidad de la dieta para conocer el impacto que algunos nutrientes, alimentos y patrones dietéticos pueden tener sobre la homeostasis telomérica y por lo tanto, sobre la salud en general. Material y métodos: se realizó una revisión bibliográfica en la base de datos PubMed para identificar los artículos publicados (en inglés o español) hasta diciembre de 2016 que cumplían los siguientes criterios: incluían sujetos humanos; eran estudios transversales; estudios de casos y controles; estudios de cohortes prospectivos o estudios de intervención; que evaluaban la relación de los nutrientes, alimentos o patrones dietéticos con la longitud de los telómeros. La estrategia de búsqueda incluía las siguientes palabras clave: nutrients or food OR food groups OR diet OR dietary pattern OR eating pattern OR dietary habits OR diet type AND telomere attrition OR telomere length. En total, se incluyeron 19 estudios transversales, cinco estudios de casos y controles, cinco estudios de cohortes prospectivos y dos estudios de intervención, incluyendo aquellos artículos que se encontraron por listas de referencias de otras publicaciones. Resultados: se encontraron asociaciones positivas entre la longitud de los telómeros y la adherencia a la dieta mediterránea y el consumo de verduras y frutas. Los resultados obtenidos para otros nutrientes, alimentos o patrones dietéticos fueron incoherentes, aunque parece que las carnes procesadas, los cereales, el alcohol y las bebidas endulzadas podrían estar asociados con telómeros más cortos. Conclusiones: la intervención dietética, y en particular la promoción de una dieta de estilo mediterráneo, podría desempeñar un papel en la protección de la integridad telomérica. Key words:Telomere. Mediterranean diet. Oxidative stress. DNA. AbstractBackground: Few studies have evaluated the relationship between diet quality and telomere integrity in humans. Telomeres are regions of non-coding DNA localized at the end of each chromosome whose length, in addition to indicating life expectancy, indicates an overall health status. The objective of this systematic review is to compile the existing evidence on the relationship between telomere length and diet quality to further explore the impact that some nutrients, foods and dietary patterns may have on telomere homeostasis and therefore, in precision nutrition strategies. Material and methods: A bibliographic review was performed in the PubMed database to identify published articles (in English or Spanish) until December 201...

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“…Some cells, such as germline cells, have greater ability to preserve telomere length through the enzymatic activity known as telomerase. Leukocyte telomere length (LTL) has been proposed to be a marker for biological aging, and shortened LTL has been related with higher allcause mortality (Honig et al 2012) as well as a variety of age-related conditions such as cardiovascular disease (Estruch et al 2013;Mainous et al 2010;Perez-Rivera et al 2014), diabetes (Zhao et al 2013), and dementia (Honig et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Mediterranean diet and leukocyte telomere length in a multi-ethnic elderly population

Honig

Schupf

et al. 2015

AGE

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Leukocyte telomere length (LTL) is considered as the marker of biological aging and may be related to environmental factors. The current study aimed to examine the relation between Mediterranean-type diet and LTL. We used a cross-sectional study of 1743 multi-ethnic community residents of New York aged 65 years or older. Mediterranean-type diet (MeDi) was calculated from dietary information collected using a food frequency questionnaire. LTL was measured from leukocyte DNA using a real-time PCR method to measure T/S ratio, the ratio of telomere (T) to single-copy gene (S) sequence. Regression analysis showed that the MeDi score was not associated with LTL in the overall study population (β=12.5; p=0.32) after adjusting for age, sex, education, ethnicity, caloric intake, smoking, and physical and leisure activities. However, we found a significant association between MeDi and LTL among non-Hispanic whites (β=48.3; p=0.05), and the results held after excluding dementia subjects (β= 49.6; p = 0.05). We further found that, in the whole population, vegetable and cereal consumption above the sex-specific population median was associated with longer LTL (β=89.1, p=0.04) and shorter LTL (β = −93.5; p = 0.03), respectively. Among non-Hispanic whites, intake of meat or dairy below sex-specific population medians was associated with longer LTL (β=154.7, p=0.05; β= 240.5, p < 0.001, respectively). We found that higher adherence to a MeDi was associated with longer LTL among whites but not among African Americans and Hispanics. Additionally, a diet high in vegetables but low in cereal, meat, and dairy might be associated with longer LTL among healthy elderly.

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Association between Telomere Length and Type 2 Diabetes Mellitus: A Meta-Analysis

Cited by 189 publications

References 32 publications

Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?

Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?

Telómeros Y Calidad De La Dieta: Una Revision Sistematica

Mediterranean diet and leukocyte telomere length in a multi-ethnic elderly population

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