2023
DOI: 10.1101/2023.05.29.23290678
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Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s disease

Abstract: INTRODUCTION: Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL and cognitive performance in middle-aged cognitively unimpaired individuals at increased risk of AD. METHODS: A total of 1,520 participants from the ALFA cohort were included. Relative telomere length was measured in leukocytes through qPCR. LTL was residualized against age and … Show more

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