Association between Telomere Length and Pediatric Obesity: A Systematic Review

Raftopoulou, Christina; Paltoglou, George; Charmandari, Evangelia

doi:10.3390/nu14061244

Cited by 8 publications

(6 citation statements)

References 159 publications

(285 reference statements)

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“…However, there are other biological processes related to gene expression and the nervous system, which have smaller P-values relative to metabolism-related biological processes. Among them telomere organisation may be related to obesity, and it has been shown that telomere length is a strong marker of biological aging and increased telomere wear has been noted in obese adults [31]. The rest of the biological processes have not been found to be associated with obesity or BMI at this time, which provides new research directions and ideas for understanding the causes of obesity.…”

Section: Resultsmentioning

confidence: 99%

Comparison of urine proteome between obese people and normal weight people

Wang,

Wei,

Zhou

et al. 2024

Preprint

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Objective: To explore whether urine proteome can reflect the difference between obese and normal weight people. Methods: Urine samples from obese and normal weight people were collected and identified by non-label quantitative proteomics using high performance liquid chromatography tandem mass spectrometry (LC-MS/MS). The difference proteins of urine proteome between obese and normal weight people were screened for protein function and biological pathway analysis. The urine proteome of obese individuals was compared with that of normal weight people, and the common differential proteins were counted to analyze the protein function and biological pathways. Reported biomarkers of obesity were searched in the urine proteome of obese individuals. Results: 38 different proteins can be identified in the urine proteome of obese people compared with normal weight people, some of which have been reported to be related to metabolism and obesity, and the biological processes of differential proteins are also related to metabolism and other processes. 8 common differential proteins in the urine proteome of obese individuals and normal weight people, among which some proteins have been reported to be related to metabolism and obesity, and the biological processes of differential proteins are also related to metabolism and other processes. Among the differential proteins in the urine proteome of obese individuals compared with the normal weight people, the reported obesity biomarkers can be matched. Conclusions: The urine proteome can distinguish the obese people from the normal weight people, and the differential proteins in the urine proteome have key proteins that are known to be related to obesity and metabolism, and the biological processes of differential proteins also related biological processes such as nutrition and metabolism. Urine proteome has the potential to explore the pathogenesis of obesity and provide personalized treatment.

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Section: Resultsmentioning

confidence: 99%

Comparison of urine proteome between obese people and normal weight people

Wang,

Wei,

Zhou

et al. 2024

Preprint

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“…This increase of spermatozoa telomere length leads to an increase of telomere length in embryos as well as inborn children. This parameter can confer a real advantage in terms of protection against some diseases like obesity 107,108 . Furthermore, the telomere length in children's chromosomes is strongly associated with the sperm telomere length 6 .…”

Section: Discussionmentioning

confidence: 99%

“…This parameter can confer a real advantage in terms of protection against some diseases like obesity. 107,108 Furthermore, the telomere length in children's chromosomes is strongly associated with the sperm telomere length. 6 Considering that long telomere could predispose to cancer development, the association of advanced paternal age and risk of cancer in offspring has been explored.…”

Section: Discussionmentioning

confidence: 99%

Impact of paternal age on assisted reproductive technology outcomes and offspring health: a systematic review

et al. 2023

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Background The increase in paternal age and the percentage of births after assisted reproductive technologies (ART) may have consequences on offspring and society's position regarding access to ART must be questioned. Most countries recommend limiting ART to men under 60 years. What is the rationale for this threshold? Objective This systematic review assesses scientific arguments to establish links between paternal age, male fertility, and offspring health. Material and methods Using the PRISMA guidelines, this systematic review of the literature analyzed 111 articles selected after screening PubMed, ScienceDirect, and Web of Science for articles published between January 1, 1995 and December 31, 2021. Results A strong correlation was highlighted between advanced paternal age and a decrease of some sperm parameters (semen volume and sperm motility) and infant morbidity (exponentially increased incidence of achondroplasia and Apert syndrome, and more moderately increased incidence of autism and schizophrenia). The impact of paternal age on pregnancy and fetal aneuploidy rates is more controversial. No association was found with spontaneous abortion rates. Discussion and conclusion The scientific parameters should be explained to older parents undergoing ART. And for countries that discuss a limit on paternal age for access to ART, the debate requires consideration of social and ethical arguments.

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“…[11] Studies have found that adults with obesity have been discovered to suffer from increased telomere attrition. [12] There is a negative association between obesity and telomere length. [13,14] While a higher BMI has been observed to be associated with shorter telomere length, [15] there is currently no scientific literature on the potential connection between WWI and telomere length.…”

Section: The Research Was Funded By the Medical Science And Technolog...mentioning

confidence: 99%

Associations between weight-adjusted-waist index and telomere length: Results from NHANES: An observational study

Xia,

Xu,

et al. 2024

Medicine

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Previous studies have demonstrated the connection between obesity and telomere length. A recently devised metric for determining obesity, the weight-adjusted-waist index (WWI), offers a distinct advantage in predicting fat and lean mass by depicting weight-independent abdominal adiposity. This article presents the results of the inaugural study on the relationship between WWI and telomere length in adult populations. The cross-sectional investigation analyzed data from 3479 participants from the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2000. To inspect linear and nonlinear correlations, we adopted weighted multiple logistic regression analysis and smooth curve fit, respectively. In addition, threshold effects and subgroup analyses were accomplished. In the fully adapted model, a significant adverse association of WWI with telomere length was detected [β = −0.02, 95% CI: (−0.03, −0.00), P value = 0.01]. The adverse correlation remained consistent across all subcategories. We also discovered an inverted U-shaped curve linking WWI and telomere length, with a conspicuous inflection point of 10.07 cm/√kg. For the first time, our research demonstrated strong links between WWI and telomere length. The inflection point suggests that controlling WWI within an optimum range might be essential for aging and health.

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Association between Telomere Length and Pediatric Obesity: A Systematic Review

Cited by 8 publications

References 159 publications

Comparison of urine proteome between obese people and normal weight people

Comparison of urine proteome between obese people and normal weight people

Impact of paternal age on assisted reproductive technology outcomes and offspring health: a systematic review

Associations between weight-adjusted-waist index and telomere length: Results from NHANES: An observational study

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