Association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and motor behavior in healthy adults: A study review

Nogueira, Nathálya Gardênia de Holanda Marinho; Bacelar, Mariane F.B.; Ferreira, Bárbara de Paula; Parma, Juliana Otoni; Lage, Guilherme Menezes

doi:10.1016/j.brainresbull.2018.11.002

“…It is the first time these results of PARIs occurrence and COMT polymorphisms were found, and clearly more research is needed to clarify such an association more broadly. Some researchers have proposed a "gene-brain-behavior" model, genes cause certain areas of the brain structure and function changes(e.g., hippocampus) [26,29], which affect the individual's cognition, emotion and behavior [29,43]. Human behavior and the brain network that dominates behavior are formed by the ingenious combination of many genes through development and the environment.…”

Section: Discussionmentioning

confidence: 99%

Association of COMT Polymorphisms with Multiple Physical Activity-Related Injuries among University Students in China

Chen

¹

,

Cai

²

,

Duan

³

et al. 2021

IJERPH

3

0

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The catechol-O-methyltransferase (COMT) is a candidate gene to provide promising evidence of psychiatric disorders, but there is a knowledge gap between the genetic factor and multiple physical activity-related injuries (PARIs). The aim of this study was to explore the contribution of COMT to the risk of PARIs among university students in the Chinese Han population. We can further search for the intrinsic risk factors for the occurrence of multiple physical activity injuries and provide a scientific basis for early screening and precise intervention for the high-risk group of college students with multiple PARIs. A 1:1 matched case-control study of 61 PARIs cases and 61 healthy controls were carried out. DNA samples of the participants were isolated from saliva and genotyped on eight SNPs of the COMT gene (rs9265, rs4680, rs6269, rs4818, rs4633, rs165655, rs165656, and rs165722) using the MALDI-TOF MS method. We found that rs6269 and rs4818 were significantly associated with PARIs, and rs6269-GG and rs4818-GG contributed to the reduced risk of PARIs. Further haplotype analysis showed a four-marker C-G-C-G haplotype (rs165722-rs6269-rs4633-rs4818) acted with a protective role in the development of PARIs (p = 0.037; OR: 0.474, 95% CI: 0.269 to 0.834). However, the interactions between club membership and rs6269 or rs4818 would significantly increase the risk of PARIs (both p < 0.001, OR: 5.121 and 4.977, respectively). This is the first study to find the contribution of COMT to PARIs occurrence, suggesting that the COMT polymorphisms and the gene–environment interactions may alter the risk of PARIs.

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“…Gervasini et al's study [37] suggested COMT gene polymorphisms may contribute to the psychopathological symptoms of bulimia nervosa patients. Another study identified that different COMT genotypes may result in different motor behaviors [38]. A Disease Markers all over the world.…”

Section: Discussionmentioning

confidence: 99%

Lack of Association between rs4680 Polymorphism in Catechol-O-Methyltransferase Gene and Alcohol Use Disorder: A Meta-Analysis

Jin

¹

,

Zhao

²

2020

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Background. The underlying mechanisms of alcohol use disorder (AUD) are regarded to be strongly associated with genetic factors. Although great efforts have been made to identify the association of rs4680 polymorphism in the catechol-o-methyltransferase gene and risk to AUD, the outcomes were still inconsistent. This study is aimed at exploring the association of rs4680 polymorphism and AUD by using a meta-analysis approach. Methods. Literature searching was undertaken across PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases. We set the search period before February 20, 2020. We used the Review Manager 5.3 (RevMan 5.3) software to estimate the effect sizes in five genetic models. Results. In total, eighteen case-control studies and two cohort studies were included in this study. The merged results of overall population indicated there was no significant association between rs4680 polymorphism and AUD: V vs. M, OR = 1.02 , 95% CI 0.93-1.12, P = 0.70 ; VV vs. MM, OR = 0.99 , 95% CI 0.79-1.23, P = 0.92 ; VM vs. MM, OR = 0.91 , 95% CI 0.81-1.03, P = 0.15 ; VV+VM vs. MM, OR = 0.95 , 95% CI 0.80-1.13, P = 0.65 ; VV vs. VM+MM, OR = 1.04 , 95% CI 0.91-1.18, P = 0.57 . Subgroup analysis by gender suggested rs4680 polymorphism was marginally associated with an elevated risk to AUD among males (VM vs. MM, OR = 0.81 , 95% CI 0.67-0.98, P = 0.03 ). However, subgroup analysis by race and diagnosis did not support any significant association. Conclusions. The present study suggests that rs4680 polymorphism has no association with AUD in the overall population, but it has a weak association with AUD in males. Carriers of VM genotype in males appear to have an increased risk to AUD.

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“…To elaborate further on this important study limitation, our small participant sample size also precluded an explorative analysis of whether other variables such as the sex of the participants or differences in their right-and left-hand performances might also relate to varied COMT genotype and cognitive flexibility. Further researchers should utilize larger participant samples and might also investigate the association of the COMT polymorphism with working memory or other executive functioning tasks (Nogueira, Bacelar, Ferreira, Parma, & Lage, 2019), perhaps using tests such as the Wisconsin Card Sort Test and N-back to provide further information regarding the relationship of cognitive flexibility, working memory, tonic and phasic dopaminergic transmission, and the role played by the PFC in these tasks.…”

Section: Discussionmentioning

confidence: 99%

Association Between the Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Manual Performance Asymmetries

Nogueira

¹

,

Fernandes

²

,

Ferreira

³

et al. 2019

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Within the cognitive domain, neuroscience and cognitive psychology researchers have investigated the relationship between handedness and cognitive skills. However, there have been few studies of the three-way association between manual asymmetry, its genetic components, and cognition even though this line of research could further an understanding of asymmetry. One enzyme involved in cognitive functions related to the dopaminergic system and to the prefrontal cortex is the catechol-O-methyltransferase (COMT), and it has a trimodal activity distribution in the human population due to its functional polymorphism known as Val158Met. This study investigated whether this COMT polymorphism is associated with asymmetries in the performance of a manual dexterity task. Forty-two right-handed undergraduate students ( Mage = 25.12, SD = 5.84; 15 women, 27 men) performed two trials each of place and remove conditions of the Grooved Pegboard Test with each hand (right and left), counterbalancing the order of the initial or starting hand. We calculated the mean time to perform the task for both hands on both trials and found, as hypothesized, that the Met/Met group gave a more asymmetrical performance than the Val/Met group under the place condition because dopamine levels reduced flexible behavior for the Val/Met group. We suspect that the place condition requires greater interhemispheric connectivity, as it requires a greater cognitive flexibility, and highly asymmetrical individuals are said to be less flexible. The findings of this study suggest a significant association between the COMT polymorphism and manual asymmetry in healthy populations.

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Association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and motor behavior in healthy adults: A study review

Cited by 16 publications

References 40 publications

Association of COMT Polymorphisms with Multiple Physical Activity-Related Injuries among University Students in China

Association of COMT Polymorphisms with Multiple Physical Activity-Related Injuries among University Students in China

Lack of Association between rs4680 Polymorphism in Catechol-O-Methyltransferase Gene and Alcohol Use Disorder: A Meta-Analysis

Association Between the Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Manual Performance Asymmetries

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