Association between the exposure to phthalates and adiposity: A meta-analysis in children and adults

Ribeiro, Cláudia; Mendes, Vania; Peleteiro, Bárbara; Delgado, Inês; Araújo, Joana; Aggerbeck, Μartine; Annesi‐Maesano, Isabella; Sarigiannis, D; Ramos, Elisabete

doi:10.1016/j.envres.2019.108780

“…A previous narrative review reported positive associations of exposure to phthalate metabolites with childhood BMI, subscapular skinfold thickness, and hip and waist circumferences in five studies, the associations of which were mostly observed among boys (3). However, a recent meta‐analysis of 29 studies in children and adults has reported inconsistencies in results from published literature on the association between the exposure to phthalates and adiposity (35). In the current study, we observed that higher HMW phthalate concentrations, specifically DNOP metabolites, at 6 years were associated with higher BMI and an increased risk of overweight and obesity in school‐age children.…”

Section: Discussionmentioning

confidence: 99%

Phthalate and Bisphenol Urinary Concentrations, Body Fat Measures, and Cardiovascular Risk Factors in Dutch School‐Age Children

Silva

¹

,

Jaddoe

²

,

Sol

³

et al. 2021

Obesity

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Objective: The purpose of this study was to investigate the associations of urinary phthalates and bisphenols at age 6 years old with body fat and cardiovascular risk factors at 6 and 10 years and with the change from 6 to 10 years. Methods: Among 471 Dutch children, the phthalates and bisphenols urinary concentrations at 6 years and BMI, fat mass index, android fat mass, blood pressure, glucose, insulin, and lipids blood concentrations at 6 and 10 years were measured. Results: An interquartile range increase in din -octyl phthalate (DNOP) metabolites concentrations at 6 years was associated with an increased risk of overweight at 6 and 10 years (odds ratio: 1.44; 95% CI: 1.11-1.87, and 1.43; 95% CI: 1.09-1.86, respectively). Also, higher DNOP metabolites concentrations were associated with higher fat mass index at 6 years, higher systolic blood pressure at 10 years, a decrease in highdensity lipoprotein cholesterol, and an increase in triglycerides concentrations from 6 to 10 years (P < 0.05). Higher total bisphenols and bisphenol A concentrations were associated with a decrease in BMI from 6 to 10 years (P < 0.01). Conclusions: DNOP metabolites are associated with overweight and an adverse cardiovascular profile in childhood. Total bisphenols and bisphenol A are associated with a decrease in BMI from 6 to 10 years.

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“…They are also used, with other functions, in personal care and consumer products in general. 46,47,48,49 In the cosmetic industry, phthalates have been used in perfumes as carriers or synthetic musk solvents, for their fixing properties. They have also been used as plasticizers in nail lacquers and hair sprays.…”

Section: Phthalatesmentioning

confidence: 99%

“…Exposure to endocrine disruptors is one of the factors contributing to the increased rate of certain health problems, such as obesity. 46,51 The main systems and organs affected by contact with EDCs are bone growth, the immune system, the cardiovascular system, the digestive system, the reproductive system, the kidney and the liver. 52 Phthalates and their metabolites have been detected in various human and animal fluids, including breast milk, seminal fluids and urine.…”

Section: Phthalatesmentioning

confidence: 99%

Synthesis of Deuterated Surrogate Standards for the Analysis of Legally Regulated Substances in Cosmetics

Beatriz¹,

González²,

Lolo³

et al. 2020

Preprint

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The presence of harmful substances in cosmetic products is regulated in most countries. In the European Union the Regulation (EC) No. 1223/2009 lays down the requirements for the marketing of cosmetic products. Among others, important families of compounds restricted in the Regulation are musks, allergenic fragrances and phthalates. To ensure product safety, improved analytical methods capable of reliably and reproducibly detecting the presence of traces of prohibited and/or restricted ingredients in raw materials and finished products are required. For the continuous improvement of the reliability of the analytical methods developed to check the compliance of cosmetic products with the Regulation, the use of appropriate surrogate standards or contaminants (substances that are added to the samples to be analyzed to establish the recovery and the reproducibility of the quantification of the analytes) are of utmost importance. One of the best kinds of surrogate standards are isotopically labeled analogs of the analytes of interest. In this work, several synthetic methods have been developed to prepare isotopically labeled analogs of atranol, chloroatranol, di-n-octylphthalate, musk xylene, and musk ambrette, which are restricted substances in cosmetic articles.

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“…Exposure to endocrine disruptors is one of the factors contributing to the increased rate of certain health problems, such as obesity. 46,51 The main systems and organs affected by contact with EDCs are bone growth, the immune system, the cardiovascular system, the digestive system, the reproductive system, the kidney and the liver. 52 Phthalates and their metabolites have been detected in various human and animal fluids, including breast milk, seminal fluids and urine.…”

Section: Phthalatesmentioning

confidence: 99%

Synthesis of Deuterated Surrogate Standards for the Analysis of Legally Regulated Substances in Cosmetics

Beatriz¹,

González²,

Lolo³

et al. 2020

Preprint

1

0

View full text Add to dashboard Cite

The presence of harmful substances in cosmetic products is regulated in most countries. In the European Union the Regulation (EC) No. 1223/2009 lays down the requirements for the marketing of cosmetic products. Among others, important families of compounds restricted in the Regulation are musks, allergenic fragrances and phthalates. To ensure product safety, improved analytical methods capable of reliably and reproducibly detecting the presence of traces of prohibited and/or restricted ingredients in raw materials and finished products are required. For the continuous improvement of the reliability of the analytical methods developed to check the compliance of cosmetic products with the Regulation, the use of appropriate surrogate standards or contaminants (substances that are added to the samples to be analyzed to establish the recovery and the reproducibility of the quantification of the analytes) are of utmost importance. One of the best kinds of surrogate standards are isotopically labeled analogs of the analytes of interest. In this work, several synthetic methods have been developed to prepare isotopically labeled analogs of atranol, chloroatranol, di-n-octylphthalate, musk xylene, and musk ambrette, which are restricted substances in cosmetic articles.

show abstract

Association between the exposure to phthalates and adiposity: A meta-analysis in children and adults

Cited by 44 publications

References 54 publications

Phthalate and Bisphenol Urinary Concentrations, Body Fat Measures, and Cardiovascular Risk Factors in Dutch School‐Age Children

Phthalate and Bisphenol Urinary Concentrations, Body Fat Measures, and Cardiovascular Risk Factors in Dutch School‐Age Children

Synthesis of Deuterated Surrogate Standards for the Analysis of Legally Regulated Substances in Cosmetics

Synthesis of Deuterated Surrogate Standards for the Analysis of Legally Regulated Substances in Cosmetics

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