Association between the IL-10 and IL-6 polymorphisms and brucellosis susceptibility: a meta-analysis

Abstract

Background: Brucellosis is a quite normal zoonotic infection, which is caused by immediate contact with animals infected with Brucella or its products. IL-10 (− 1082 G/A, − 819 C/T, − 592C/A) and IL-6-174 G/C polymorphisms have a great relationship with IL-10 and IL-6 production, which brings about Brucellosis pathogenesis and development. So far, the results of published literatures were controversial. Now, we perform a meta-analysis in different ethnic populations to get a more precise estimate of above polymorphisms with Brucellosis susceptibility. Methods: Both OR and corresponding 95%CI were enrolled to make an assessment of the association strength through extracting genotyping frequency of cases and controls. The χ2-test based Q-statistic and I 2 statistics were applied. If there was no evident heterogeneity, the fixed-effects model would be applied. If not, the random-effects model would be used. Results: The significant associations were only found in Asian population of − 819 loci under three genetic models as follows: (Allele model: OR = 0.60, 95%CI = 0.44-0.82, P = 0.001), (homozygote comparison: OR = 0.24, 95%CI = 0.09-0.62, P = 0.003), (recessive genetic model: OR = 0.22, 95%CI = 0.05-0.91, P = 0.036). Conclusion: In conclusion, IL-10 − 819 loci polymorphism contributes no risk to Caucasian population but may be associated with decreased risk in Asian population. And IL-10-1082 G/A, 592 loci and IL-6-174 G/C polymorphism are not associated with Brucellosis risk.

Genetic polymorphism of IL-17 influences susceptibility to recurrent pregnancy loss in a Chinese population

“…Genetic polymorphisms vary significantly across different countries and regions, impacted by the distinct racial backgrounds present. [18][19][20][21][22][23][24] Our research focuses on the Chinese population, whose genetic polymorphisms differ from those observed in Egypt and Saudi Arabia. Given that Egypt is in North Africa and Saudi Arabia is in West Asia, their genetic profiles are markedly different from those of the Chinese population.…”

Genetic Polymorphism of Lipoprotein-Associated Phospholipase A2 Influences Susceptibility to Gestational Diabetes Mellitus in Chinese Population

“…Secondly, bioinformatics and meta-analysis are very hot topics in genetic-association studies in recent years. [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] Therefore, we should conduct more relevant studies about PLA2G7 gene in bioinformatics and meta-analysis, which may contribute to GDM diagnosis, prevention, and treatment.…”

MMP-3 gene regulates the carcinogenesis and metabolic process of ovarian cancer, evidence from a Chinese population: Observational study and meta-analysis

“…All methods applying the present meta-analysis were based on published literatures. [11][12][13][14][15][16][17][18][19][20][21][22][23][24] 2.4. Statistical analysis SPSS17, STATA11 software, t test, χ2 test statistic tools were applied in our investigation, as reported by previous literatures.…”