Association between the interleukin 4 gene -590C>T promoter polymorphism and asthma in Xinjiang Uighur children

Abstract

ABSTRACT. We investigated the association between the interleukin 4 gene (IL-4) -590C>T polymorphism and forced expiratory volume in one second (FEV 1 ) values, immunoglobulin E (IgE) levels, and susceptibility to asthma in Uighur children. IL-4 -590C>T frequencies were analyzed in 38 bronchial asthmatic patients and 35 non-asthmatic controls. Polymerase chain reaction and direct sequencing were applied to determine the residue at position -590 of IL-4. Total serum IgE levels were detected by enzyme-linked immunosorbent assay, while lung function was examined by professionals. There were significant differences in the distribution of IL-4 -590C>T genotypes and alleles between patient and control groups (genotypes: chi-square = 11.476, P < 0.05; alleles: chi-square = 14.572, P < 0.05). Frequencies of CC, CT, and TT genotypes were 21, 29, and 50% among patients, and 49, 37, and 14% among controls, respectively, indicating that the T allele was significantly more frequent in the asthma group than in the control group. Total serum IgE levels were significantly higher (P < 0.05) and FEV 1 values were significantly lower (F = 13.294, P < 0.05) in patients than in control subjects of the same genotype. In conclusion, the IL-4 -590C>T polymorphism is related to bronchial asthma in Uighur children, and the T allele may constitute a susceptibility factor in this group. Furthermore, this genetic variant can result in raised IgE levels and decreased FEV 1 values, suggesting that both factors are associated with bronchial asthma in Uighur children.

IL-4-C-590T locus polymorphism and susceptibility to asthma in children: a meta-analysis

“…According to the criteria, a total of seven articles were selected, 15 , 16 , 17 , 18 , 19 , 20 , 21 including two in Western countries and five in Asia, with a total of 860 patients in the asthma group and 810 patients in the control group. Details of the filter process were shown in Fig.…”

“…A total of seven articles 15 , 16 , 17 , 18 , 19 , 20 , 21 were included in the study, of which five were from Asian studies and two were from European and American studies. The results showed a correlation between the IL-4-C590T gene polymorphism and childhood asthma susceptibility.…”

Interleukin-4 Single Nucleotide Polymorphism C-590t Polymorphisms in Relation to Asthma

“…This result was further confirmed at allelic level, where the mutant allele (T) was more frequent among asthma patients than controls with significant difference. Significant association of this SNP with asthma was recorded worldwide such as in Japan (7) , Taiwan (8) , Algeria (9) , Germany (10) , west Siberia (2) , Macedonia (11) , China (12) and Iran (13) . However non-significant association was also previously reported in United Kingdom (14) , China (15) and Brazil (16) .…”

Polymorphisms in the interleukin 4 promoter -589C/T gene and the risk of asthma: a systematic review and meta-analysis

“…At the same time, EOS activation, proliferation, release a variety of pro-inflammatory mediators, cause chronic allergic reactions, and destroy their own tissues and functions. A number of studies have suggested that IL-4 gene polymorphism is closely related to bronchial asthma and respiratory hyperresponsiveness (3), but there have been some differences in the conclusions of recent studies, which have also involved small sample sizes (4). A number of studies have suggested that high expression of the IL-4-590C/T gene may be an important cause of the inducement of bronchial asthma (5,6).…”