Association between the rs2288947 polymorphism of the lncRNA <i>TINCR</i> gene and the risk of recurrent miscarriage in a Southern Chinese population

Huang, Wendong; Zhou, Huazhong; Pi, Lei; Xu, Yufen; Fu, Lanyan; Yang, Yanfang; Che, Di

doi:10.1002/jcla.22919

Cited by 6 publications

(5 citation statements)

References 25 publications

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“…29 , 30 , 31 We had also carry on a study about relationship between LncRNA TINCR (rs2288947) polymorphisms and susceptibility of RM, but the result showed there was no significant correlation between rs2288947 and RM. 32 Positive result had arisen in our following researches, which indicated that some LncRNA polymorphisms related to breast cancer were also associated with the development of RM. Thus, there is reason to believe that more LncRNAs polymorphisms which might be association with RM are waiting to be found.…”

Section: Discussionmentioning

confidence: 90%

“…Although the function of most LncRNAs is still unclear, many studies have revealed that some LncRNAs involve in the onset and development of abortion 29‐31 . We had also carry on a study about relationship between LncRNA TINCR (rs2288947) polymorphisms and susceptibility of RM, but the result showed there was no significant correlation between rs2288947 and RM 32 . Positive result had arisen in our following researches, which indicated that some LncRNA polymorphisms related to breast cancer were also associated with the development of RM.…”

Section: Discussionmentioning

confidence: 99%

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Association between the rs3802201 polymorphism of the lncRNA MIR2052HG gene and the risk of recurrent miscarriage in a Southern Chinese population

Mai

Cai

Lin

et al. 2021

Clinical Laboratory Analysis

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Background Plenty of studies have indicated that some genetic polymorphisms of the breast cancer which associated with its susceptibility may also be related to the susceptibility of abortion. MIR2052HG plays an important role in the onset and progression of breast cancer by maintaining the level of ERα, but to the best of our knowledge, the correlation between risk of recurrent abortion and MIR2052HG rs3802201 C>G polymorphism is still unclear. Therefore, we conducted this case‐control study to investigate whether MIR2052HG rs3802201 C>G polymorphism is associated with susceptibility of recurrent miscarriage (RM). Methods We recruited 392 healthy controls and 248 patients with RM to process this research, the participants were all from southern China, and genotyping was performed by TaqMan method. Results Our results showed that there was no evidence indicates the MIR2052HG rs3802201 C>G is related to RM (CG and CC: adjusted OR = 0.970, 95% CI = 0.694–1.355, p = 0.8577; GG and CC: adjusted OR = 0.743, 95% CI = 0.416–1.330, p = 0.3174; dominant model: adjusted OR = 0.925, 95% CI = 0.672–1.272, p = 0.6298; recessive model: adjusted OR = 0.751, 95% CI = 0.430–1.321, p = 0.3233). Conclusion We verified that the MIR2052HG rs3802201 C>G allele might be uncorrelated to the RM risk, but these findings require further validation in multicenter studies with larger sample size and different ethnicities.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Association between the rs3802201 polymorphism of the lncRNA MIR2052HG gene and the risk of recurrent miscarriage in a Southern Chinese population

Mai

Cai

Lin

et al. 2021

Clinical Laboratory Analysis

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“…LncRNAs have received much attention in recent years due to their regulatory roles 43 . Some lncRNAs, such as TINCR, 31 CCAT2, 16 MALAT1, 44 and SOX2OT, 45 have already been involved in RSA pathogenesis. HOTAIR is associated with many human diseases, including breast cancer, 46 esophageal squamous cell carcinoma, 47 thyroid cancer, 48 cervical cancer, 49 chronic myeloid leukemia, 50 and polycystic ovarian syndrome 51 .…”

Section: Discussionmentioning

confidence: 99%

“…[26][27][28][29] Evidence showed that genetics might play different roles in susceptibility to RSA. 16 Few studies have reported an association between SNPs in lncRNA genes and RSA 30,31 ; however, no study has investigated the relationship of HOTAIR gene polymorphisms to RSA development. In the current study, we aimed to genotype HOTAIR rs12826786 C/T, rs920778 T/C, rs4759314 A/G, and rs1899663 G/T SNPs in order to explore such association in Iranian women.…”

Section: Introductionmentioning

confidence: 99%

Genetic variants of HOTAIR are associated with susceptibility to recurrent spontaneous abortion: A preliminary case–control study

Salimi

Sargazi

Nia

et al. 2021

J of Obstet and Gynaecol

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Aim To investigate the association between Hox transcript antisenses RNA (HOTAIR) polymorphisms, rs12826786 C/T, rs920778 T/C, rs4759314 A/G, and rs1899663 G/T, with recurrent spontaneous abortion (RSA) susceptibility in the Iranian women. Methods We enrolled 161 patients diagnosed with RSA and 177 healthy women with at least one live birth without a history of abortion. Genotyping of HOTAIR polymorphisms was carried out using both restriction fragment length polymorphism‐polymerase chain reaction and amplification refractory mutation system‐polymerase chain reaction methods. Odds ratios (ORs) with 95% confidence intervals (CIs) were assessed to estimate the strength of association. Results Different inheritance models of rs12826786 C/T, rs920778 T/C, and rs1899663 G/T polymorphisms significantly enhanced the risk of RSA (p < 0.05), whereas the rs4759314 A/G polymorphism was correlated with diminished risk of developing RSA under recessive AA versus GA + GG (OR 0.42 [95% CI = 0.19–0.91]), log‐additive GG versus GA vs. GG (OR 0.67 [95% CI = 0.48–0.93]), and allelic A versus G (OR 0.65 [95% CI = 0.47–0.92]) models. Moreover, the TGTC, TTCT, TTTC, CGTC, CGTT, CTCC, CTCT, CTTC, and CTTT haplotypes of rs920778/rs1899663/rs12826786/ significantly increased the risk of RSA. The studied variants were not in strong linkage disequilibrium. Conclusions Our results indicated that variations in the HOTAIR gene might serve as beneficial biomarkers for determining susceptibility to RSA. To confirm these findings, replication studies with a larger population and different races are needed.

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“…LncRNAs have been revealed to play important roles in various cellular functions, including affecting the pluripotency and differentiation of embryonic stem cells, regulating cell apoptosis and cell cycle, and performing important functions in the origin, growth, evolution, selection and other aspects of human life (9)(10)(11). Recent several researches have found that lncRNAs may be related to RSA (12,13). However, there is only one study investigating relation of lncRNA with unexplained recurrent pregnancy loss (URPL) (14).…”

Section: Introductionmentioning

confidence: 99%

Long Noncoding RNA RP11-115N4.1 Promotes Inflammatory Responses by Interacting With HNRNPH3 and Enhancing the Transcription of HSP70 in Unexplained Recurrent Spontaneous Abortion

et al. 2021

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BackgroundUnexplained recurrent spontaneous abortion (URSA) is a common pregnancy complication and the etiology is unknown. URSA-associated lncRNAs are expected to be potential biomarkers for diagnosis, and might be related to the disease pathogenesis.ObjectiveTo investigate differential lncRNAs in peripheral blood of non-pregnant URSA patients and matched healthy control women and to explore the possible mechanism of differential lncRNAs leading to URSA.MethodsWe profiled lncRNAs expression in peripheral blood from 5 non-pregnant URSA patients and 5 matched healthy control women by lncRNA microarray analysis. Functions of URSA-associated lncRNAs were further investigated in vitro.ResultsRP11-115N4.1 was identified as the most differentially expressed lncRNA which was highly upregulated in peripheral blood of non-pregnant URSA patients (P = 3.63E-07, Fold change = 2.96), and this dysregulation was further validated in approximately 26.67% additional patients (4/15). RP11-115N4.1 expression was detected in both lymphocytes and monocytes of human peripheral blood, and in vitro overexpression of RP11-115N4.1 decreased cell proliferation in K562 cells significantly. Furthermore, heat-shock HSP70 genes (HSPA1A and HSPA1B) were found to be significantly upregulated upon RP11-115N4.1 overexpression by transcriptome analysis (HSPA1A (P = 4.39E-08, Fold change = 4.17), HSPA1B (P = 2.26E-06, Fold change = 2.99)). RNA pull down and RNA immunoprecipitation assay (RIP) analysis demonstrated that RP11-115N4.1 bound to HNRNPH3 protein directly, which in turn activate heat-shock proteins (HSP70) analyzed by protein-protein interaction and HNRNPH3 knockdown assays. Most importantly, the high expression of HSP70 was also verified in the serum of URSA patients and the supernatant of K562 cells with RP11-115N4.1 activation, and HSP70 in supernatant can exacerbate inflammatory responses in monocytes by inducing IL-6, IL-1β, and TNF-α and inhibit the migration of trophoblast cells, which might associate with URSA.ConclusionOur results demonstrated that the activation of RP11-115N4.1 can significantly increase the protein level of HSP70 via binding to HNRNPH3, which may modulate the immune responses and related to URSA. Moreover, RP11-115N4.1 may be a novel etiological biomarker and a new therapeutic target for URSA.

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Association between the rs2288947 polymorphism of the lncRNA TINCR gene and the risk of recurrent miscarriage in a Southern Chinese population

Cited by 6 publications

References 25 publications

Association between the rs3802201 polymorphism of the lncRNA MIR2052HG gene and the risk of recurrent miscarriage in a Southern Chinese population

Association between the rs3802201 polymorphism of the lncRNA MIR2052HG gene and the risk of recurrent miscarriage in a Southern Chinese population

Genetic variants of HOTAIR are associated with susceptibility to recurrent spontaneous abortion: A preliminary case–control study

Long Noncoding RNA RP11-115N4.1 Promotes Inflammatory Responses by Interacting With HNRNPH3 and Enhancing the Transcription of HSP70 in Unexplained Recurrent Spontaneous Abortion

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