Association between the XRCC3 Thr241Met Polymorphism and Breast Cancer Risk: an Updated Meta-analysis of 36 Case-control Studies

Mao, Changfei; Qian, Wen-Yi; Wu, Jianzhong; Sun, Dawei; Tang, Jinhai

doi:10.7314/apjcp.2014.15.16.6613

Cited by 21 publications

(20 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the meta-analytical level, Thr241Met polymorphism was related to increased risk of breast cancer when all investigations were grouped together. [20,21,22] That was in accordance with the results from the current work, where XRCC3 241Met was associated with increased risk for breast cancer, posing a 3.21 fold upraised risk on its carriers.…”

Section: Discussionsupporting

confidence: 92%

“…The XRCC3 (X-ray repair cross-complementing group 3) encodes an element of the RecA/Rad51-related protein family which contributes to HRR in order to repair DNA damage and preserve chromosome stability. [20] Concern has been raised about the association of Thr241Met with breast cancer risk, but the results remain controversial rather than conclusive. At the meta-analytical level, Thr241Met polymorphism was related to increased risk of breast cancer when all investigations were grouped together.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of DNA Repair Genes Polymorphisms on Incidence and Prognosis of Breast Cancer in an Egyptian Cohort

Zaher¹,

Hemida²,

Al-Naggar³

2017

JCRT

View full text Add to dashboard Cite

Background: Sporadic breast cancer might be caused by low-penetrance genes, including genes constituting the DNA repair pathways. Defective DNA repair is a common imprint of cancer that promotes the accretion of DNA errors and genomic instability. The clustering of damage in DNA may stimulate breast carcinogenesis. Aims: The goal of the study is to evaluate the role of single nucleotide polymorphisms in DNA repair genes XRCC1 Arg399Gln, XPD Lys751Gln, RAD51 G135C and XRCC3 Thr241Met as genetic indicators of susceptibility to breast cancer and to evaluate their role in treatment outcome. Methodology: The study included 248 females diagnosed with primary breast cancer and 232 normal healthy females. Patients were clinically followed up for 5 years after completing chemotherapy. Genomic DNA was isolated and the four polymorphisms under investigation were assessed by PCR-RFLP technique. Findings: XRCC1 399Gln, XPD 751Gln and XRCC3 241Met alleles were significantly associated with breast cancer risk (OR = 2.63, 2.17 and 3.21; respectively), with carriers having lower disease free survival (DSF). When grouping patients based on the number of affected genotypes they carry, DFS decreased as the number of affected genotypes increased (P accum <0.001), patients carrying three (HR=4.74, p<0.001) or two (HR=3.35, p=0.005) affected genotypes had significantly worse DFS compared with those carrying zero (reference) or one (HR=1.37, p=0.093) affected genotype. RAD51 5'UTR G135C polymorphism was not associated with breast cancer risk (p=0.932) or with DFS. Conclusion: XRCC1 Arg399Gln, XPD Lys751Gln and XRCC3 Thr241Met polymorphisms may take a significant part in sporadic breast cancer as risk factors and in prognosis, where patients carrying XRCC1 Arg/Arg, XPD Lys/Lys and XRCC3 Thr/Thr genotypes had significantly diminished risk for breast cancer and higher DFS. DFS decreased as the number of affected genotypes increased. But RAD51 5'UTR G135C polymorphism did not associate with either risk or prognosis of breast cancer.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Impact of DNA Repair Genes Polymorphisms on Incidence and Prognosis of Breast Cancer in an Egyptian Cohort

Zaher¹,

Hemida²,

Al-Naggar³

2017

JCRT

View full text Add to dashboard Cite

show abstract

“…DNA repair mechanisms involve nucleotide excision repair, base excision repair, and double-strand break repair (DSBR) pathways (Wood et al, 2001). The DNA repair enzyme X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3), a member of the DSBR pathway, plays a direct role in homologous recombination, important for chromosomal integrity and the repair of damaged DNA (Shin et al, 2008;Mao et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

DNA repair gene XRCC3 T241M polymorphism and susceptibility to hepatocellular carcinoma in a Chinese population: a meta-analysis

Rb¹,

Ys²,

Ar³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Numerous studies have evaluated the association between the X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3) T241M polymorphism and hepatocellular carcinoma (HCC) risk. However, the results of such investigations have proved inconsistent. Therefore, we performed a meta-analysis of the association between this polymorphism and HCC risk in the Chinese population. Published literature from PubMed and China National Knowledge Infrastructure databases was retrieved, and a total of 5 case-control studies consisting of 2967 patients and 3874 controls were included in this meta-analysis, which revealed a significant association between the XRCC3 T241M polymorphism and HCC risk (TT vs MM: OR = 6.54, 95%CI = 2.14-19.99; TT vs MT: OR = 4.72, 95%CI = 2.26-9.86; dominant model: OR = 0.38, 95%CI = 0.26-0.57; recessive model: OR = 1.27, 95%CI = 0.99-1.62). In a subgroup analysis by sample size (number of subjects > 1000), similar results were obtained. Thus, XRCC3 T241M polymorphism may constitute a risk factor for HCC in the Chinese population.

show abstract

“…Although this meta-analysis did not show the significant association between XRCC3 rs861539 polymorphism and oral cancer risks, the present results also provided new evidence for the susceptibility and etiology of oral cancer. In recent years, there are some meta-analyses about XRCC3 polymorphisms and cancer risks, which comprised breast cancer, cervical cancer, colorectal cancer, gliomas and head and neck caner published in the journal Asian Pac J Cancer Prev and the results are not concordant, suggesting this polymorphism plays different role in diverse types of cancer (Yin et al, 2012;Jiang et al, 2013;Nassiri et al, 2013;Qin et al, 2013;Mao et al, 2014). It is well known that systematic review and meta-analyses are considered the highest level of evidence in Evidencebased Medicine.…”

Section: Discussionmentioning

confidence: 99%

Lack of Influence of an XRCC3 Gene Polymorphism on Oral Cancer Susceptibility: Meta-analysis

Zhang

Cui²,

Xu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

-1.11). In the stratified analysis by ethnicity, no significant associations were found among Asians and Caucasians. On stratification by tumor type, no significant associations were found for cancer and oral premalignant lesions. Conclusions: The XRCC3 gene polymorphism was not found to be associated with the risk of oral cancer. Considering the limited quality of the included case-control studies, more high quality studies with large sample size are needed to verify the above conclusion.

show abstract

Association between the XRCC3 Thr241Met Polymorphism and Breast Cancer Risk: an Updated Meta-analysis of 36 Case-control Studies

Cited by 21 publications

References 38 publications

Impact of DNA Repair Genes Polymorphisms on Incidence and Prognosis of Breast Cancer in an Egyptian Cohort

Impact of DNA Repair Genes Polymorphisms on Incidence and Prognosis of Breast Cancer in an Egyptian Cohort

DNA repair gene XRCC3 T241M polymorphism and susceptibility to hepatocellular carcinoma in a Chinese population: a meta-analysis

Lack of Influence of an XRCC3 Gene Polymorphism on Oral Cancer Susceptibility: Meta-analysis

Contact Info

Product

Resources

About