Association between TNF-alpha polymorphism and the age of first suicide attempt in chronic patients with schizophrenia

Lang, Xiaoe; Trihn, Tammy H.; Wu, Hanjing Emily; Tong, Yongsheng; Xiu, Meihong; Zhang, Xiang Yang

doi:10.18632/aging.102692

Cited by 9 publications

(3 citation statements)

References 62 publications

(77 reference statements)

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“…A Chinese study compared suicidal patients (SAs and/or SI) to non-suicidal patients, all of them affected by schizophrenia. The genotypic and allelic distributions of rs1800629 (–308 G/A) and rs1799964 (–1031 C/T) polymorphisms did not differ between the groups ( 43 ).…”

Section: Resultsmentioning

confidence: 90%

Genetic variations related to inflammation in suicidal ideation and behavior: A systematic review

et al. 2022

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Background/objectivesImmune-inflammatory changes have been found in all types of suicidal ideation and behavior (SIB), independently of associated mental disorders. Since several Single Nucleotide Polymorphisms (SNPs) affect the function of inflammation-related genes, we searched the literature for genetic variations potentially altering inflammatory processes in SIB.MethodsWe included studies that looked for associations between SIB and SNPs in genes related to inflammatory processes. Case reports, literature reviews, and animal studies were excluded. Articles were retrieved from PubMed and PsycINFO databases, Google Scholar and GreySource Index until September 17th, 2022. Quality was assessed using Q-Genie.ResultsWe analyzed 32 studies. SIB has been associated with eighteen SNPs located in genes encoding for interleukin-8 (rs4073), C-reactive protein (rs1130864), tumor necrosis factor α (rs1800629, rs361525, and rs1099724), tumor necrosis factor receptor 2 (rs1061622), transforming growth factor β-1 (rs1982073), acid phosphatase 1 (rs7419262, rs300774), interleukin-10 (rs1800896), interferon γ (rs2430561), amino-carboxy muconate semialdehyde decarboxylase (rs2121337), interleukin 7 (rs10448044, rs10448042), macrophage migration inhibitory factor (rs755622), interleukin 1-α (rs1800587), and interleukin 1-β (rs1143634 and rs16944. A genome-wide association study reported one association at the threshold of significance with the rs300774 SNP, located in the 2p25 region containing ACP1 gene.DiscussionThe studies included were methodologically and clinically diverse and of moderate quality. Their findings suggest that some inflammation-related SNPs could increase the likelihood of SIB but the evidence to date is insufficient. Further research using gene-gene (GxG) and gene-environment (GxE) approaches is warranted.Systematic review registration[https://www.crd.york.ac.uk], identifier [CRD42022296310].

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Section: Resultsmentioning

confidence: 90%

Genetic variations related to inflammation in suicidal ideation and behavior: A systematic review

et al. 2022

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“…Some previous studies have described a positive relationship between TNF-alpha and depression [ 63 , 64 ]. In addition, TNF-alpha polymorphisms have been associated with an earlier age of first SA in individuals with schizophrenia [ 65 ] and with SA in depressed patients (Y. K [ 74 ]). However, a cumulative meta-analysis that investigated cytokines in patients with MDD found a clear signal for CRP, and IL-6, but an uncertain effect of TNF-alpha due to significant heterogeneity in study-specific estimates and inconsistencies between subgroups [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Higher levels of plasma Adrenocorticotropic hormone (ACTH) are associated with lower suicidal ideation in depressed patients compared to controls and suicide attempters, independently from depression severity

Strumila,

Lengvenyte,

Zdanavicius

et al. 2024

Comprehensive Psychoneuroendocrinology

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“…For the studies of TNF-α polymorphism, TNF-α-308 G/A is associated with SA (21) and male suicide (22). However, others reported no such associations (23,24).…”

Section: Introductionmentioning

confidence: 99%

Time-Specific Associations of Tumor Necrosis Factor-α Levels and Polymorphisms (−850 C/T or −308 G/A) With Suicidal Ideation in Acute Coronary Syndrome Patients

et al. 2021

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Background: Considering the association of inflammation with suicide and acute coronary syndrome (ACS), we investigated the individual and interactive effects of serum tumor necrosis factor-alpha (sTNFα) levels and two polymorphisms (−850 C/T and −308 G/A) on suicidal ideation (SI) after ACS.Methods: The SI status using items on the Montgomery–Åsberg Depression Rating Scale (MADRS), related covariates including sociodemographic and clinical characteristics, sTNFα levels, and tumor necrosis factor-alpha (TNF-α) polymorphisms were evaluated in 969 patients within 2 weeks after ACS. Of the patients, 711 were evaluated 1 year later for SI. Multivariate logistic regression models were used to calculate individual and interactive associations after adjusting for the covariates.Results: Higher (vs. lower) sTNFα levels and the −850 C/T or T/T (vs. C/C) polymorphism were significantly associated with SI 2 weeks after ACS, while only higher sTNFα levels were significantly associated with SI after 1 year. Significant interactive effects were detected between sTNFα (higher) levels and the −850 C/T (C/C or C/T) polymorphism on SI 2 weeks after ACS and between the two (−850 CC or CT and −308 G/A or AA) polymorphisms on SI 1 year after ACS.Conclusions: The sTNFα level and two polymorphisms (−850C/T and −308 G/A), separately or in combination, could be time-specific biomarkers for SI in ACS. Focused interventions for ACS patients at risk of SI might reduce the suicidal burden in patients with ACS.

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Association between TNF-alpha polymorphism and the age of first suicide attempt in chronic patients with schizophrenia

Cited by 9 publications

References 62 publications

Genetic variations related to inflammation in suicidal ideation and behavior: A systematic review

Genetic variations related to inflammation in suicidal ideation and behavior: A systematic review

Higher levels of plasma Adrenocorticotropic hormone (ACTH) are associated with lower suicidal ideation in depressed patients compared to controls and suicide attempters, independently from depression severity

Time-Specific Associations of Tumor Necrosis Factor-α Levels and Polymorphisms (−850 C/T or −308 G/A) With Suicidal Ideation in Acute Coronary Syndrome Patients

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