2023
DOI: 10.1002/jmv.28455
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Association between trans fatty acids and COVID‐19: A multivariate Mendelian randomization study

Abstract: Traditional observational studies have suggested a potential association between trans fatty acids (TFAs), which are considered to be health-damaging fatty acids, and coronavirus disease 2019 (COVID-19). However, whether there is a causal relationship between them is currently unclear. We aimed to investigate the causal link between genetically determined TFAs and COVID-19. We performed univariate and multivariate Mendelian randomization (MR) studies using summary statistics from the European Pedigree TFAs (n … Show more

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Cited by 6 publications
(2 citation statements)
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“…To establish independence between the instrumental variables and COVID-19, we utilized the PhenoScannerV2 database 4 to identify and remove potential confounding factors that could impact both exposure and outcome. This meticulous approach ensured the integrity of the IVs and their association with COVID-19 ( 21 ).…”
Section: Methodsmentioning
confidence: 99%
“…To establish independence between the instrumental variables and COVID-19, we utilized the PhenoScannerV2 database 4 to identify and remove potential confounding factors that could impact both exposure and outcome. This meticulous approach ensured the integrity of the IVs and their association with COVID-19 ( 21 ).…”
Section: Methodsmentioning
confidence: 99%
“…We assessed the proximity of genetic variants by applying a linkage disequilibrium (LD) threshold of r2 less than 0.1 within a 500-kilobase span, and conducted clumping analysis using European ancestry data from the 1000 Genomes Project (22,23). The potency of each SNP was appraised using the F-statistic, discounting those with an F-statistic below 10 based on the formula: F = β² / SE² (24). This sieve was instrumental in re ning the pool of SNPs to those signi cantly associated with the outcomes at a p-value below 1×10 − 5, which were then extracted and omitted from further analysis (22).…”
Section: Strength Test and Selection Of Instrumental Variablesmentioning
confidence: 99%