Association between troponin level and medium-term mortality in 20 000 hospital patients

Abstract

IntroductionCardiac troponin (cTn) concentrations above the manufacturer recommended upper limit of normal (ULN) are frequently seen in hospital patients without a clinical presentation consistent with type 1 myocardial infarction, and the significance of this is uncertain. The aim of this study was to assess the relationship between medium-term mortality and cTn concentration in a large consecutive hospital population, regardless of whether there was a clinical indication for performing the test.MethodThis prospective observational study included 20 000 consecutive in-hospital and outpatient patients who had a blood test for any reason at a large teaching hospital, and in whom a hs-cTnI assay was measured, regardless of the original clinical indication. Mortality was obtained via NHS Digital.ResultsA total of 20 000 patients were included in the analysis and 18 282 of these (91.4%) did not have a clinical indication for cardiac troponin I (cTnI) testing. Overall, 2825 (14.1%) patients died at a median of 809 days. The mortality was significantly higher if the cTnI concentration was above the ULN (45.3% vs 12.3% p<0.001 log rank). Multivariable Cox analysis demonstrated that the log10cTnI concentration was independently associated with mortality (HR 1.76 (95% CI 1.65 to 1.88)). Landmark analysis, excluding deaths within 30 days, showed the relationship between cTnI concentration and mortality persisted.ConclusionIn a large, unselected hospital population, in 91.4% of whom there was no clinical indication for testing, cTnI concentration was independently associated with medium-term cardiovascular and non-cardiovascular mortality in the statistical model tested.

High-Sensitivity Troponin I and Cardiovascular Events in Stable Coronary Artery Disease: Insights from a Longitudinal Outpatient Study

“…Several studies were published suggesting that detectable cTn, not necessarily above the 99th percentile, is related to adverse outcomes in chronic cardiac and non-cardiac conditions in the absence of cell necrosis. Some of the studies enrolled populations that were not routinely tested for troponin in an effort to understand the potential prognostic role of troponin and explore the mechanisms underlying its release [13][14][15].…”

High Sensitivity Troponin I and Cardiovascular Events in Stable Coronary Artery Disease: Insights from a Longitudinal Outpatient Study

“…Several studies were published suggesting that detectable cTn, not necessarily above the 99th percentile, is related to adverse outcomes in chronic cardiac and non-cardiac conditions in the absence of cell necrosis. Some of the studies enrolled populations that were not routinely tested for troponin in an effort to understand the potential prognostic role of troponin and explore the mechanisms underlying its release [13][14][15].…”