Association between TSLP gene polymorphism and bronchial asthma in children in Beni Suef Governorate in Egypt

Elmaraghy, Mohammed Adel; Hodieb, Mahmood Mohammed; Khattab, Rasha Abd El Razek; Abdelgalel, Mohammed Nabeh

doi:10.1007/s00580-017-2626-9

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…Along with the concept presentation of “noninvasive detection technology,” more and more noninvasive and objective methods for evaluating the degree of airway inflammation were proposed. Breath detection is a widespread concern, owing to exhaled gas composition and its concentration that are different in various diseases or the same diseases with different severity, so the detection of some gas composition and its concentration in exhaled gas can diagnose and monitor the disease, providing a new idea for auxiliary diagnosis and disease assessment of AR [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Significance of Exhaled Nitric Oxide and Carbon Monoxide in Auxiliary Diagnosis and Evaluation of Allergic Rhinitis

Zhao

Qin

Jin

et al. 2022

Mediators of Inflammation

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Objective. The concentration of exhaled NO and CO is considered as a candidate marker of respiratory inflammatory disease. This report discusses the exhaled NO and CO in the auxiliary diagnosis and evaluation of allergic rhinitis (AR). Methods. 60 AR patients from October 2017 to March 2019, compared with 30 healthy controls. The severity of AR disease was distinguished by symptom score. Both groups were tested for exhaled nitric oxide through the nose or mouth and exhale carbon monoxide through the mouth. AR patients received glucocorticoid nasal spray for 1 month and were tested again for nNO, eNO, eCO, and symptom score. Results. Before treatment, all the nNO, eNO, and eCO of the AR group were higher than the control group. There were differences in the severe and moderate subgroup: severe > moderate > mild . eCO was not significantly different between the mild and control groups. The nNO, eNO, and eCO levels were positively correlated with symptom score. After treatment, nNO decreased significantly in the three subgroups; eNO and eCO in the severe AR group decreased significantly. Drawing the ROC curve, the area under curve (AUC) of nNO is 0.978. The AUC of eNO and eCO was 0.786 and 0.577, respectively. Conclusion. The nNO, eNO, and eCO in the AR group are higher than healthy people, which positively correlated with the severity of AR symptoms. The detection of nNO, eNO, and eCO can monitor the changes of AR. The detection of nNO level as an indicator of AR auxiliary diagnosis has high accuracy.

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Section: Introductionmentioning

confidence: 99%

Significance of Exhaled Nitric Oxide and Carbon Monoxide in Auxiliary Diagnosis and Evaluation of Allergic Rhinitis

Zhao

Qin

Jin

et al. 2022

Mediators of Inflammation

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“…Among the studies conducted on the gene polymorphisms of TSLP gene and asthma, several SNPs have been shown to impact the susceptibility to this disease. Interestingly, one candidate SNP rs2289276 has consistently demonstrated a protective effect, whereby carrying the SNP is associated with a lower risk of asthma [ 235 , 236 , 241 ]. Furthermore, the lower risk was more pronounced in females, meaning that SNPs can act as sex-specific risk factors [ 241 ].…”

Section: Variants Of Alarmins Genes In Asthmamentioning

confidence: 99%

“…Therefore, the sex-specific patterns of alarmin SNPs could be justified by the alterations that are made in sex hormone production by these gene polymorphisms. Some TSLP SNPs have inconsistent associations, for instance, rs2289278 was reported to have no effects on asthma risk in an Egyptian population [ 235 ] but was shown to have significant associations with asthma severity in Iranians [ 236 ]. Conflicting results in these studies might be due to low frequency of such SNPs in the studied populations or racial and environmental differences.…”

Section: Variants Of Alarmins Genes In Asthmamentioning

confidence: 99%

The Role of Airway Epithelial Cell Alarmins in Asthma

Whetstone

Ranjbar

Omer

et al. 2022

Cells

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The airway epithelium is the first line of defense for the lungs, detecting inhaled environmental threats through pattern recognition receptors expressed transmembrane or intracellularly. Activation of pattern recognition receptors triggers the release of alarmin cytokines IL-25, IL-33, and TSLP. These alarmins are important mediators of inflammation, with receptors widely expressed in structural cells as well as innate and adaptive immune cells. Many of the key effector cells in the allergic cascade also produce alarmins, thereby contributing to the airways disease by driving downstream type 2 inflammatory processes. Randomized controlled clinical trials have demonstrated benefit when blockade of TSLP and IL-33 were added to standard of care medications, suggesting these are important new targets for treatment of asthma. With genome-wide association studies demonstrating associations between single-nucleotide polymorphisms of the TSLP and IL-33 gene and risk of asthma, it will be important to understand which subsets of asthma patients will benefit most from anti-alarmin therapy.

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