Association between Urinary Triclosan and Serum Testosterone Levels in U.S. Adult Males from NHANES, 2011–2012

Yan, Judy; Joseph, Michael A.; Reynolds, Simone; Geer, Laura A.

doi:10.3390/ijerph17207412

Cited by 7 publications

(3 citation statements)

References 45 publications

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“…Potential multicollinearity among the predictor variables was assessed by examining the variance inflation factors' (VIF) diagnostic statistics. Although there is no formal VIF value for detecting multicollinearity, values of VIF 10 or above are often indicative of multicollinearity [48]. The unstandardized coefficients with a 95% confidence interval (95% CI) obtained from the models were reported.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Smoking, Physical Activity, Screen Time, and Quality of Life among Adolescents

Dong

Ding

Chen

et al. 2020

IJERPH

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Background: Quality of life (QOL) is a crucial part of evaluating health conditions IN adolescents. The purposes of this study were to (1) examine the relationship of QOL and smoking, physical activity (PA) and screen time (ST) among Chinese adolescents, (2) explore the relationship between PA-ST combination and QOL of adolescents, and (3) investigate the dose-response relationship between PA-ST and QOL. Methods: This study randomly selected 12,900 adolescents (11–18 years) from 13 administrative regions in Shandong Province, China. The data gathering tools for Smoking (tobacco), PA (PAQ-A) and ST (average daily time for ST) and QOL questionnaire (child and adolescent quality of life scale) were completed among all adolescents. Statistical analysis was performed by T test, chi-square test and multiple linear regression. Results: 12,641 adolescents (aged 12–18) completed the study. In multiple linear regression models, the result demonstrated that the adolescents from rural areas, with high ST, low PA, and smoking, with older age and low socioeconomic status, showed a lower QOL score. First-time smokers under 10 years revealed the lowest QOL, and PA > 30 min five days per week have the highest QOL. In addition, boys and girls with PA > 30 min three to four days per week in high ST group obtain the higher scores (boys β = 5.951, girls β = 3.699) than low PA-low ST groups. Conclusions: Adolescents from rural areas suffer from a relatively poorer QOL. More than 30 min of PA five or more days for boys and three or four days per week for girls could decrease negative effects of ST and improve QOL.

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Section: Discussionmentioning

confidence: 99%

Relationship between Smoking, Physical Activity, Screen Time, and Quality of Life among Adolescents

Dong

Ding

Chen

et al. 2020

IJERPH

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“…Drawing from prior research, − a comprehensive range of potential confounders was considered, including race/ethnicity (Mexican American, other Hispanic, non-Hispanic White, non-Hispanic Black, other race), level of education (less than high school, high school and above), body mass index (underweight, normal, overweight, obese), time of blood draw (morning, afternoon, evening), season of collection (November 1 through April 30, May 1 through October 31), household poverty-income ratio (<1, ≥ 1), and cotinine levels (tobacco exposed or unexposed). The categorization of tobacco exposure was based on the limits of detection (LOD) of cotinine, set at 0.015 ng/mL …”

Section: Methodsmentioning

confidence: 99%

Insights into Triclosan-Induced Endocrine Disruption: Evidence from the National Health and Nutrition Examination Survey and Zebrafish Models

Li,

Xian,

Ren

et al. 2024

Environ. Health

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Triclosan (TCS) has garnered significant attention due to its widespread use and associated endocrine-disrupting effects. However, its impact on the neuroendocrine system and underlying mechanisms remain poorly understood. Here, we established correlations between TCS exposure and serum sex hormone levels in participants of the National Health and Nutrition Examination Survey (NHANES). Additionally, we investigated TCS's influence on the neuroendocrine system using adult zebrafish exposed to environmentally relevant concentrations of TCS (0.361−48.2 μg/L) for 21 days. Assessment of reproductive and neurotoxicity included histopathological examination and behavioral tests. Transcriptomics, proteomics analyses, and biochemical detection were employed to elucidate mechanisms underlying TCS-induced neuroendocrine disruption. Significant correlations were found between TCS exposure and estradiol, testosterone, and sex hormone-binding globulin levels in NHANES participants. In addition, TCS exposure inhibited ovary development and spermatogenesis in zebrafish. Transcriptomics and proteomics analysis revealed gender-specific key signaling and metabolism-related pathways implicated in TCS-induced reproductive toxicity. Moreover, TCS exposure induced nervous system impairment, as evidenced by histological changes and altered motor behavior, possibly associated with oxidative damage. Correlation analysis further highlighted the potential connection between endocrine system disruption and nervous system impairment following TCS exposure. Overall, this study provided evidence supporting TCS-induced endocrine disruption and offered insights into its underlying mechanisms.

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“…Specifically, a study on male Wistar rats demonstrated the absence of effects of TCS in the Hershberger assay, as well as on the parameters that were evaluated in the reproductive toxicity study [ 150 ]. Another work on serum testosterone levels in human adult males found that TCS did not reduce testosterone levels [ 151 ]; low-dose TCS exposure was not associated with risks of abnormal semen quality in a study on 406 men from a reproductive clinic [ 152 ]. In a study on children and adolescents aged 6–19 years, little association of TCS and testosterone levels was found [ 153 ].…”

Section: Toxicity Studies On Tcsmentioning

confidence: 99%

Triclosan: A Small Molecule with Controversial Roles

et al. 2022

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Triclosan (TCS), a broad-spectrum antimicrobial agent, has been widely used in personal care products, medical products, plastic cutting boards, and food storage containers. Colgate Total® toothpaste, containing 10 mM TCS, is effective in controlling biofilm formation and maintaining gingival health. Given its broad usage, TCS is present ubiquitously in the environment. Given its strong lipophilicity and accumulation ability in organisms, it is potentially harmful to biohealth. Several reports suggest the toxicity of this compound, which is inserted in the class of endocrine disrupting chemicals (EDCs). In September 2016, TCS was banned by the U.S. Food and Drug Administration (FDA) and the European Union in soap products. Despite these problems, its application in personal care products within certain limits is still allowed. Today, it is still unclear whether TCS is truly toxic to mammals and the adverse effects of continuous, long-term, and low concentration exposure remain unknown. Indeed, some recent reports suggest the use of TCS as a repositioned drug for cancer treatment and cutaneous leishmaniasis. In this scenario it is necessary to investigate the advantages and disadvantages of TCS, to understand whether its use is advisable or not. This review intends to highlight the pros and cons that are associated with the use of TCS in humans.

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Association between Urinary Triclosan and Serum Testosterone Levels in U.S. Adult Males from NHANES, 2011–2012

Cited by 7 publications

References 45 publications

Relationship between Smoking, Physical Activity, Screen Time, and Quality of Life among Adolescents

Relationship between Smoking, Physical Activity, Screen Time, and Quality of Life among Adolescents

Insights into Triclosan-Induced Endocrine Disruption: Evidence from the National Health and Nutrition Examination Survey and Zebrafish Models

Triclosan: A Small Molecule with Controversial Roles

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