Association between variations in the number of hospital beds and inpatient chemo/radiotherapy for breast cancer: a study using a large claim database

Matsumoto, Haruki; Ogiya, Rin; Matsuda, Shinya

doi:10.1080/0284186x.2020.1787506

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…Database-based studies are also increasing in the investigation of risk factors for disease [25,26,27,28]. Studies using databases to study breast cancer include studies on treatment selection for breast cancer and epidemiological studies of male breast cancer [29,30], but no studies have used databases to identify risk factors for BCRL. If database-based studies are shown to be useful in identifying risk factors for BCRL, it is expected that BCRL prevention activities will be improved.…”

Section: Introductionmentioning

confidence: 99%

Database study of risk factors for breast cancer-related lymphedema: statistical analysis of 2359 cases in 10 years

Matsumoto

Ushio

Kimura

et al. 2023

Preprint

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Background Identification of risk factors is important for the prevention of Breast Cancer-Related Lymphedema (BCRL), and epidemiological large-scale studies are needed. Although database studies are suitable for large-scale surveys, there have been no studies using databases to investigate risk factors for BCRL. The purpose of this study was to test the hypothesis that database-based studies are useful in identifying risk factors for BCRL. Methods Patients diagnosed with breast cancer during a 10-year period from April 2009 to March 2020 were selected from the medical database of Hiroshima University Hospital. As a retrospective observational study, risk factors for BCRL were validated by logistic regression analysis (p < 0.05). Results A total of 4471 breast cancer patients were selected and 2359 met study criteria; the incidence of BCRL was 4.8%. Risk factors for BCRL ultimately identified by multivariate logistic regression analysis were obesity with BMI 25 to 30 (OR = 3.066, 95%CI: 1.408 ~ 6.677), severe obesity with BMI > 30 (OR = 5.791, 95%CI: 2.239 ~ 14.97), surgical axillary lymph node dissection (OR = 3.212, 95%CI: 1 .918 ~ 5.378), chemotherapy with docetaxel (OR = 1.795, 95%CI: 1.062 ~ 3.032), and conventional radiation to the breast or chest wall with lymph nodes in the irradiated area (OR = 3.299, 95%CI: 1.842 ~ 5.910). Conclusions The risk factors for BCRL identified in this study were generally similar to those in previous studies, indicating that database-based studies are useful for identifying risk factors for BCRL. A multicenter study involving a larger number of patients and study items needs to be conducted in order to more fully elucidate the risk factors for BCRL.

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Section: Introductionmentioning

confidence: 99%

Database study of risk factors for breast cancer-related lymphedema: statistical analysis of 2359 cases in 10 years

Matsumoto

Ushio

Kimura

et al. 2023

Preprint

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Database study of risk factors for breast cancer-related lymphedema: a statistical analysis of 2359 cases over 10 years

Matsumoto,

Ushio,

Kimura

et al. 2024

Surg Today

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Purpose Identifying risk factors for breast cancer-related lymphedema (BCRL) is crucial for its prevention, necessitating large-scale epidemiological studies. Despite their suitability for large-scale surveys, to our knowledge, databases have not been the basis of any study done to investigate BCRL risk factors. This study aimed to test the hypothesis that a database-based study would be useful for identifying BCRL risk factors. Methods Patients with breast cancer diagnosed between April 2009 and March 2020 were identified from the Hiroshima University Hospital’s medical database. This retrospective observational study validated the risk factors for BCRL using logistic regression analysis (p < 0.05). Results Among the total 4471 breast cancer patients identified, 2359 met the study criteria, with a BCRL incidence of 4.8%. Identified risk factors included obesity with a BMI of 25–30 (OR = 3.066, 95% CI 1.408–6.677), severe obesity with a BMI > 30 (OR = 5.791, 95% CI 2.239–14.97), surgical axillary lymph node dissection (OR = 3.212, 95% CI 1.918–5.378), chemotherapy with docetaxel (OR = 1.795, 95% CI 1.062–3.032), and conventional radiation to the breast or chest wall including lymph nodes in the irradiated area (OR = 3.299, 95% CI 1.842–5.910). Conclusions The BCRL risk factors identified by our database analysis were in line with those documented in previous studies, indicating the usefulness of database-based studies. Future studies should include more patients and study items.

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Impact of Location of Residence and Distance to Cancer Centre on Medical Oncology Consultation and Neoadjuvant Chemotherapy for Triple-Negative and HER2-Positive Breast Cancer

Yee,

Hallet,

Look Hong

et al. 2024

Current Oncology

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Despite consensus guidelines, most patients with early-stage triple-negative (TN) and HER2-positive (HER2+) breast cancer do not see a medical oncologist prior to surgery and do not receive neoadjuvant chemotherapy (NAC). To understand barriers to care, we aimed to characterize the relationship between geography (region of residence and cancer centre proximity) and receipt of a pre-treatment medical oncology consultation and NAC for patients with TN and HER2+ breast cancer. Using linked administrative datasets in Ontario, Canada, we performed a retrospective population-based analysis of women diagnosed with stage I–III TN or HER2+ breast cancer from 2012 to 2020. The outcomes were a pre-treatment medical oncology consultation and the initiation of NAC. We created choropleth maps to assess the distribution of the outcomes and cancer centres across census divisions. To assess the relationship between distance to the nearest cancer centre and outcomes, we performed multivariable regression analyses adjusted for relevant factors, including tumour extent and nodal status. Of 14,647 patients, 29.9% received a pre-treatment medical oncology consultation and 77.7% received NAC. Mapping demonstrated high interregional variability, ranging across census divisions from 12.5% to 64.3% for medical oncology consultation and from 8.8% to 64.3% for NAC. In the full cohort, compared to a distance of ≤5 km from the nearest cancer centre, only 10–25 km was significantly associated with lower odds of NAC (OR 0.83, 95% CI 0.70–0.99). Greater distances were not associated with pre-treatment medical oncology consultation. The interregional variability in medical oncology consultation and NAC for patients with TN and HER2+ breast cancer suggests that regional and/or provider practice patterns underlie discrepancies in the referral for and receipt of NAC. These findings can inform interventions to improve equitable access to NAC for eligible patients.

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Association between variations in the number of hospital beds and inpatient chemo/radiotherapy for breast cancer: a study using a large claim database

Cited by 3 publications

References 15 publications

Database study of risk factors for breast cancer-related lymphedema: statistical analysis of 2359 cases in 10 years

Database study of risk factors for breast cancer-related lymphedema: statistical analysis of 2359 cases in 10 years

Database study of risk factors for breast cancer-related lymphedema: a statistical analysis of 2359 cases over 10 years

Impact of Location of Residence and Distance to Cancer Centre on Medical Oncology Consultation and Neoadjuvant Chemotherapy for Triple-Negative and HER2-Positive Breast Cancer

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