Association between vasomotor symptoms and sarcopenia assessed by L3 skeletal muscle index among Korean menopausal women

Ryu, Ki-Jin; Kim, Hyun Kyun; Lee, Yeon Ju; Park, Hyuntae; Kim, Tak

doi:10.1097/gme.0000000000001879

Cited by 2 publications

(5 citation statements)

References 28 publications

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“…The mean score was 12.96 ± 5.41. The score was moderate (9)(10)(11)(12)(13)(14)(15)(16) in the majority of women (58.5%), it was severe (≥17) in 21.7% and mild (5-8) in 15.1% of women. Most of the women (80.2%) had moderate to severe MRS scores suggestive of a poor quality of life.…”

Section: Resultsmentioning

confidence: 99%

“…In our study, although the total MRS score did not show any correlation with sarcopenia, somatic symptoms were significantly severe in women with sarcopenia ( P = 0.044) when compared to women without sarcopenia. Ryu et al 16 reported that vasomotor symptoms were less common in women with sarcopenia than in those without sarcopenia in 295 Korean menopausal women aged 40-65 years. Longitudinal studies are required to investigate the causal relationships and underlying mechanisms.…”

Section: Discussionmentioning

confidence: 99%

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Quality of life in postmenopausal women and its association with sarcopenia

Sriramaneni,

Selvan,

Kumar S

et al. 2024

Menopause

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Objectives With the menopausal transition, there is a decline in estrogen concentration with potential health consequences affecting the quality of life. The loss of muscle mass, strength, and function, known as sarcopenia is common in postmenopausal women. The primary objective of this study is to assess the quality of life in postmenopausal women and its association with sarcopenia. Methods This was a cross-sectional study conducted in 106 postmenopausal women. Menopausal symptoms and risk of sarcopenia were assessed with Menopause Rating Scale (MRS) and Strength Assistance walking Rising from a chair Climbing stairs and Falls (SARC-F) questionnaires, respectively. Sarcopenia was defined and assessed according to the Asian Working Group for Sarcopenia guidelines 2019. Results The mean age was 59.34 ± 7.21 years and the mean age at menopause was 49.50 ± 2.67 years. The majority (80.2%) of the women had high MRS scores (≥9). The majority had mild somatic, moderate psychologic, and severe urogenital symptoms. SARC-F score was low in 85.8% of women. Most of the women (45.3%) had sarcopenia. Somatic symptoms were significant in women with sarcopenia. Urogenital symptoms were significant with greater menopausal duration. Appendicular skeletal muscle mass index was significantly less with greater menopausal duration. MRS score positively correlated with both SARC-F score and sarcopenia. Sarcopenia was significantly associated with greater menopausal duration. Conclusions Most of the women had moderate to severe MRS scores suggestive of a poor quality of life. The majority of the women had sarcopenia. Most of the women felt they were strong (according to SARC-F score) despite sarcopenia. Although quality of life did not differ significantly with the duration of menopause, urogenital symptoms were significantly severe with greater menopausal duration. Despite no significant association between quality of life and sarcopenia in postmenopausal women, somatic symptoms were significant in women with sarcopenia. The greater menopausal duration was associated significantly with sarcopenia.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Quality of life in postmenopausal women and its association with sarcopenia

Sriramaneni,

Selvan,

Kumar S

et al. 2024

Menopause

View full text Add to dashboard Cite

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“…In addition, the paraspinal muscle index was positively associated with the prevalence of vasomotor symptoms (odds ratio 1.06; 95% confidence interval 1.01-1.11). (76) The results of another study also demonstrated a relationship between vasomotor symptoms and skeletal muscle index in Korean menopausal women. (76) Based on the research results described above, estrogen, testosterone, and progesterone can be used as options to improve the quality of life of elderly women.…”

Section: Systematic Review and Metaanalysismentioning

confidence: 90%

“…(76) The results of another study also demonstrated a relationship between vasomotor symptoms and skeletal muscle index in Korean menopausal women. (76) Based on the research results described above, estrogen, testosterone, and progesterone can be used as options to improve the quality of life of elderly women. However, it should also be noted that estrogen significantly affects the central nervous system.…”

Section: Systematic Review and Metaanalysismentioning

confidence: 90%

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Role of sex steroid hormone on hand grip strength and cognitive function in the elderly

Parwanto,

Tjahyadi,

Amalia

et al. 2023

Univ Med

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The aging process is associated with changes in hormone levels. There is a noticeable change in estrogen levels in women, while in men, there is a change in testosterone levels. In the elderly, as a result of the aging process, changes in these hormone levels affect handgrip strength, and cognitive function. In both women and men, the function of several organs is influenced by sex steroid hormones, namely Oestrogen and androgens. There are two theories of steroid action mechanism on target cells, namely steroid hormone action mechanism genomically and non-genomically. The function and action mechanism of steroid hormone is important because it is the basis of the hormonal aspect for muscle mass, handgrip strength, and cognitive function. Due to the aging process, hormonal changes in the elderly are different compared to the previous period. This has consequences for changes in metabolic processes that affect the body’s condition, including changes in the composition of bones, muscles, and other tissues, such as the brain. In the aging process, it is important to pay attention to nutritional factors because they contribute to hormone levels that help maintain muscle mass, body mass index, hand grip strength, and cognitive function. In the brain, the sex steroid hormone has activating and organizational effects mediated by intracellular or transmembrane G-protein-coupled receptors. Articles published in English in the last 9 years (from 2014 to 2023) were retrieved from Science Direct, PubMed, Springer link, Oxford and Nature using relevant searching terms. The fact that testosterone bioavailability is predominated in the brain in relation to its activity and significant positive association with processing speed, sustained attention, and working memory in older men. To obtain a better quality of life for the elderly, nutritional factors must be considered to maintain optimal sex steroid hormone levels, hand grip strength, and cognitive function.

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Association between vasomotor symptoms and sarcopenia assessed by L3 skeletal muscle index among Korean menopausal women

Cited by 2 publications

References 28 publications

Quality of life in postmenopausal women and its association with sarcopenia

Quality of life in postmenopausal women and its association with sarcopenia

Role of sex steroid hormone on hand grip strength and cognitive function in the elderly

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