Association between ventricular arrhythmias and myocardial mechanical dispersion assessed by strain analysis in patients with nonischemic cardiomyopathy

Kosiuk, Jędrzej; Dinov, Borislav; Bollmann, Andreas; Koutalas, Emmanuel; Müssigbrodt, Andreas; Sommer, Philip; Arya, Arash; Richter, Sergio; Hindricks, Gerhard; Breithardt, Ole A.

doi:10.1007/s00392-015-0875-7

Cited by 23 publications

(10 citation statements)

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“…Studies have shown a moderate correlation between the prevalence of myocardial fibrosis, which is revealed by cardiac MR, and mechanical dispersion, which is measured with STE ( r : .52, P <.001) . Previous studies have investigated ventricular conduction heterogeneity in various disease conditions with echocardiographic and electrocardiographic methods . Haugaa et al .…”

Section: Discussionmentioning

confidence: 99%

Mechanical dispersion and global longitudinal strain by speckle tracking echocardiography: Predictors of appropriate implantable cardioverter defibrillator therapy in hypertrophic cardiomyopathy

et al. 2017

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Purpose:In this study, we investigated whether mechanical dispersion which reflects electrical abnormality and other echocardiographic and clinic parameters predict appropriate ICD shock in patients undergone ICD implantation for hypertrophic cardiomyopathy. Methods:Sixty-three patients who received ICD implantation for primary or secondary prevention were included in the study. Patients' clinical, electrocardiographic, 2D classic, and speckle tracking echocardiographic data were collected.Mechanical dispersion was defined as the standard deviation of time to peak negative strain in 18 left ventricular segments. Appropriate ICD therapy was defined as cardioversion or defibrillation due to ventricular tachycardia or fibrillation. Patients were divided into two groups as occurrence or the absence of appropriate ICD therapy.Results: A total of 17 (26.9%) patients were observed to have an appropriate ICD therapy during follow-up periods. In patients who performed appropriate ICD therapy, a larger left atrial volume index, higher sudden cardiac death (SCD)-Risk Score, longer mechanical dispersion, and decreased global longitudinal peak strain (GLPS) were observed. In multivariate logistic regression analysis, including (GLPS, mechanical dispersion, LAVi, and SCD-Risk Score) was used to determine independent predictors of occurrence of appropriate ICD therapy during the follow-up. Mechanical dispersion, GLPS, and SCD-Risk Score were found to be independent predictors of occurrence of appropriate ICD therapy. Conclusions:Mechanical dispersion, GLPS, and SCD-Risk Score were found to be predictive for appropriate ICD therapy in patients receiving ICD implantation. Readily measurable mechanical dispersion and GLPS could be helpful to distinguish patients at high risk who could optimally benefit from ICD therapy. K E Y W O R D Selectromechanical delay, hypertrophic cardiomyopathy, myocardial strain

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Section: Discussionmentioning

confidence: 99%

Mechanical dispersion and global longitudinal strain by speckle tracking echocardiography: Predictors of appropriate implantable cardioverter defibrillator therapy in hypertrophic cardiomyopathy

et al. 2017

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“…Основными конечными точками в исследованиях, где проводилась оценка ГПД и/или МД ЛЖ, являлись "аритмическая" конечная точка (5 исследований) [14,18,19,21,25], большие сердечно-сосудистые неблагоприятные события (MACE -Major adverse cardiovascular events) (5 исследований) [15,16,20,22,24] и обратное ремоделирование ЛЖ (1 исследование) [23].…”

Section: конечные точки и неблагоприятные исходыunclassified

“…Совокупность указанных событий мы рассчитывали, как большие MACE, с целью проведения дальнейшего метаанализа. В большинстве исследований, включенных в наш анализ, были представлены данные ГПД ЛЖ [14][15][16][17][19][20][21][22][23][24][25], в трех исследованиях [14,16,21], кроме того, представлены показатели МД ЛЖ, и в одном исследовании [18] проводилась только оценка значений МД ЛЖ. В таблице 3 представлены основные значения показателей ГПД и МД ЛЖ, а также данные о конечных точках и количестве событий в каждой группе.…”

Section: конечные точки и неблагоприятные исходыunclassified

Prognostic value of left ventricular global longitudinal strain and mechanical dispersion by speckle tracking echocardiography in patients with ischemic and nonischemic cardiomyopathy: a systematic review and meta-analysis

et al. 2022

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Aim. To conduct a systematic review and meta-analysis in order to evaluate the prognostic value of left ventricular global longitudinal strain (LV GLS) and LV mechanical dispersion (LVMD) in ischemic and nonischemic cardiomyopathy.Material and methods. We searched PubMed, Google Scholar and Embase for studies on the prognostic value of LV GLS and LVMD in ischemic and nonischemic cardiomyopathy. Hazard ratios (HR) from included studies were pooled for metaanalysis.Results. Twelve studies were selected from 314 publications for this systematic review and meta-analysis. In total, 2624 patients (mean age, 57,3 years; mean follow-up, 40,8 months) were included in the analysis. Meta-analysis showed that decreased LV GLS was associated with an increased risk of ventricular arrhythmias (VAs) (adjusted HR: 1,10 per 1% of GLS; 95% CI: 1,01-1,19; p=0,03) and major adverse cardiovascular events (MACE): adjusted HR: 1,22 per 1% of GLS; 95% CI: 1,11-1,33; p<0,0001). Patients with VAs had greater LVMD than those without it (weighted mean difference, 33,69 ms; 95% CI: -41,32 to -26,05; p<0,0001). Each 10 ms increment of LVMD was significantly and independently associated with VA episodes (adjusted HR: 1,18; 95% CI: 1,08-1,29; p=0,0002).Conclusions. LV GLS and LVMD assessed using speckle tracking provides important predictive value and can be used as an effective tool for stratifying risk in patients with ischemic and nonischemic cardiomyopathy.

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“…Preliminary data indicate that quantification of wasted myocardial work can help identify a substrate for improvement with CRT ( Figure 7) [63,64]. GLS was helpful in predicting reverse remodeling and 1-year mortality after CRT implantation [65], and longitudinal deformation-based measures of LV dyssynchrony proved to be strong prognosticators of ventricular arrhythmias in HFrEF [66,67]. The incremental value in predicting ventricular tachycardia/fibrillation was demonstrated for reduced longitudinal strain in the inferior wall [68], which underpins the importance of LV regional function assessment in the diagnostic work-up in…”

Section: Role Of Echocardiography In Prognosis and Risk Prediction In Hfmentioning

confidence: 99%

Echocardiography in patients with heart failure: recent advances and future perspectives

Kosmala¹,

Marwick²,

Przewlocka‐Kosmala³

2021

Kardiol Pol

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Association between ventricular arrhythmias and myocardial mechanical dispersion assessed by strain analysis in patients with nonischemic cardiomyopathy

Abstract: In this small cohort of NICM patients, greater MD was associated with a higher incidence of VT/VF.

Cited by 23 publications

References 20 publications

Mechanical dispersion and global longitudinal strain by speckle tracking echocardiography: Predictors of appropriate implantable cardioverter defibrillator therapy in hypertrophic cardiomyopathy

Mechanical dispersion and global longitudinal strain by speckle tracking echocardiography: Predictors of appropriate implantable cardioverter defibrillator therapy in hypertrophic cardiomyopathy

Prognostic value of left ventricular global longitudinal strain and mechanical dispersion by speckle tracking echocardiography in patients with ischemic and nonischemic cardiomyopathy: a systematic review and meta-analysis

Echocardiography in patients with heart failure: recent advances and future perspectives

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