Association between ventricular repolarization and main cardiovascular risk factors

Pshenichnikov, I; Shipilova, T; Karai, Deniss; Riiupulk, Jevgeni; Veski, K; Pilt, Kristjan; Kaik, J.

doi:10.3109/14017431.2010.532232

Cited by 4 publications

(11 citation statements)

References 20 publications

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“…The characteristics of these studies are summarized in Tables 1 and 2. 1,2,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] …”

Section: Resultsmentioning

confidence: 99%

“…Finally, certain studies have concluded that QT interval and dispersion increase in obese women (and visceral obesity), whereas other studies did not observe this. 13 Several features of study design seem to contribute to these contradicting data, including that participants in these different studies differed by age, sex, and blood pressure status. This, along with limitations of observations and lack of research on the impact of genetics, could have played a role in these conflicting results.…”

Section: Principal Findingsmentioning

confidence: 97%

“…Other studies have suggested that inhomogeneous ventricular repolarization correlates with hypertension even without LVH as a result of increased pulse pressure, impaired elastic properties of the aorta, or increased afterload. 13 Elevated blood pressure may also result in higher QT interval and dispersion (independent of LV mass). Finally, certain studies have concluded that QT interval and dispersion increase in obese women (and visceral obesity), whereas other studies did not observe this.…”

Section: Principal Findingsmentioning

confidence: 99%

“…Pshenichnikov et al 13 evaluated 302 women aged 50-69 years. Participant age, history of smoking, abdominal obesity, hyperlipidemia, increased fasting plasma glucose (or diabetes mellitus), microalbuminuria, and family history of CVD had no association with ventricular repolarization.…”

Section: Associations Of Blood Pressure and Lipids With Ecg Abnormalimentioning

confidence: 99%

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Association of Traditional Cardiovascular Risk Factors With Development of Major and Minor Electrocardiographic Abnormalities

Healy

Lloyd‐Jones

2016

Cardiology in Review

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Electrocardiographic (ECG) abnormalities are prevalent in middle aged and are associated with risk of adverse cardiovascular events. It is unclear whether and to what extent traditional risk factors are associated with the development of ECG abnormalities. To determine whether traditional cardiovascular risk factors are associated with the presence or development of ECG abnormalities, we performed a systematic review of the English-language literature for cross-sectional and prospective studies examining associations between traditional cardiovascular risk factors and ECG abnormalities, including major and minor ECG abnormalities, isolated nonspecific ST-segment and T-wave abnormalities, other ST-segment and T-wave abnormalities, QT interval, Q waves, and QRS duration. Of the 202 papers initially identified, 19 were eligible for inclusion. We examined data analyzing risk factor associations with ECG abnormalities in individuals free of cardiovascular disease. For composite major or minor ECG abnormalities, black race, older age, higher blood pressure, use of antihypertensive medications, higher body mass index, diabetes, smoking, and evidence of left ventricular hypertrophy or higher left ventricular mass are the factors most commonly associated with prevalence and incidence. Risk factor associations differ somewhat according to types of specific ECG abnormalities. Because major and minor ECG abnormalities have important and independent prognostic significance, understanding the groups at risk for their development may inform prevention strategies focused on modifiable risk factors to reduce the burden of ECG abnormalities, which may in turn promote CVD prevention.

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“…The characteristics of these studies are summarized in Tables 1 and 2. 1,2,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] …”

Section: Resultsmentioning

confidence: 99%

Section: Principal Findingsmentioning

confidence: 97%

Section: Principal Findingsmentioning

confidence: 99%

Section: Associations Of Blood Pressure and Lipids With Ecg Abnormalimentioning

confidence: 99%

See 2 more Smart Citations

Association of Traditional Cardiovascular Risk Factors With Development of Major and Minor Electrocardiographic Abnormalities

Healy

Lloyd‐Jones

2016

Cardiology in Review

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show abstract

“…Although the study population and the control group were similar in demographic characteristics (age, gender, blood pressure, BMI, physical condition), an increase in LVM was attributed to PV. In addition, previous studies have demonstrated that QT, QTd and Tp-Te prolongation well correlates with LVM 30-32. In conclusion, hyper viscocity may affect repolarization parameters in several ways.…”

Section: Discussionmentioning

confidence: 58%

Electrocardiographic Findings in Patients with Polycythemia Vera

Kayrak¹,

Acar²,

Gül³

et al. 2012

Int. J. Med. Sci.

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Background: The 12-lead surface electrocardiogram (ECG) is a useful tool to predict both atrial and ventricular arrhythmias via P-wave and QT measurements and its derivatives. Polycythemia vera (PV) is a chronic myeloproliferative disorder associated with cardiovascular events. The aim of this study was to assess ECG findings of patients with PV.Method and materials: Sixty patients with PV (34 male, mean age 58±11 years) and 60 age and gender-matched healthy volunteers were enrolled into the study. From the 12-lead surface ECG, P-wave and both conventional QT measurements and transmyocardial repolarization parameters (Tpeak-Tend interval (Tp-Te) and derivatives) were evaluated digitally by two experienced cardiologists. In addition, a novel parameter, Pi was calculated digitally as the standard deviation of the P-wave duration across the 12 ECG leads.Results: QT duration and corrected QT interval were significantly longer in the PV group compared to healthy controls (p<0.01 and p<0.01, respectively). The Tp-Te was longer and the Tp-Te/QT ratio was significantly higher in the PV group compared to the controls. P-wave analyses showed that all P-wave parameters including Pmax, Pmin, P dispersion, and Pi were significantly prolonged in PV patients compared to the controls. The increase of both Tp-Te and P max in the PV group was independent of age, BMI, diabetes and hypertension, gender, systolic blood pressure, hemoglobin, hematocrit, left atrial dimension, left ventricular end-diastolic diameter and early deceleration time in a univariate analysis of co-variance model (F=11.097, p=0.001 and F=31.537, p=0.0001, respectively).Conclusion: The present study demonstrated that PV may be associated with electrocardiographic abnormalities of both atrium and ventricle.

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Association of major and minor ECG abnormalities with traditional cardiovascular risk factors in the general population: a large scale study

Sahranavard,

Alimi,

Arabkhazaei

et al. 2024

Sci Rep

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Cardiovascular disease (CVD) can be determined and quantified using the electrocardiogram (ECG) analysis. Identification of the risk factors associated with ECG abnormalities may advise prevention approaches to decrease CVD burden. In this study we aimed to investigate the association between CVD risk factors and minor and major ECG abnormalities in a general Iranian adult population. This study was conducted in 2010 and covered a population of 9035 males and females aged 35 to 65 years recruiting from the phase I of Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) cohort study. The participants were drawn by a stratified cluster random sampling technique. The Bivariate and multinomial logistic regression analysis were conducted considering gender stratification to explore the association of ECG abnormalities with traditional cardiovascular risk factors. There was a significant association between minor and major ECG abnormalities and hypertension (HTN), type 2 diabetes (T2DM), smoking, and physical activity (p < 0.005). There was a significant trend, in both genders, for increasing major abnormalities as the number of CVD risk factors increased. But, only in women, the minor abnormalities increase in frequency as the number of CVD risk factors increased. The results of multinomial logistic regression showed that men with HTN [ARRR = 1.25, 95% CI 0.99, 1.57] and T2DM [ARRR = 1.31, 95% CI 0.99, 1.74] had the highest likelihood to have major abnormalities, although these are not statistically significant. For women, those with HTN had the highest likelihood to have major [ARRR = 1.36, 95% CI 1.13, 1.63] and minor [ARRR = 1.35, 95% CI 1.15, 1.58] abnormalities. Also, women aged > 60 years were more likely to have major [ARRR = 2.01, 95% CI 1.49, 2.74] and minor [ARRR = 1.59, 95% CI 1.20, 2.10] abnormalities compared to women aged < 45 years. Age and HTN were significantly associated with major and minor ECG abnormalities in women, and, on the other hand, HTN and T2DM were associated with major abnormalities in men. Taken together, these findings suggest that healthcare providers should advise preventive approaches to the asymptomatic adults with both major and minor electrocardiographic abnormalities that may predict cardiovascular risk.

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Association between ventricular repolarization and main cardiovascular risk factors

Abstract: In Tallinn women population, electrocardiographic parameters reflecting ventricular repolarization are associated with systolic blood pressure, pulse pressure, blood pressure value grade, heart rate and left ventricular hypertrophy.

Cited by 4 publications

References 20 publications

Association of Traditional Cardiovascular Risk Factors With Development of Major and Minor Electrocardiographic Abnormalities

Association of Traditional Cardiovascular Risk Factors With Development of Major and Minor Electrocardiographic Abnormalities

Electrocardiographic Findings in Patients with Polycythemia Vera

Association of major and minor ECG abnormalities with traditional cardiovascular risk factors in the general population: a large scale study

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