Association between vitamin D and prediabetes

Abstract

Background: Previous studies showed conflicting results for associations between vitamin D and prediabetes. The study aimed to make a systematic review and meta-analysis for the association between vitamin D and prediabetes. Methods: We searched for articles identifying associations between vitamin D and prediabetes published in English until July 2019 in following databases (PubMed, Web of Science, EMBASE, Medline, Google Scholar, and Cochrane databases). Finally, we conducted these analyses (heterogeneities examination, meta-regression analyses, sensitivity analysis, and publication bias examination) using STATA 12.0 software (Stata Corporation, College Station, TX, USA). Q test and I 2 were applied to examine heterogeneities between studies. Results: Twelve studies were finally included in the present study. The study included 4 studies to explore the association between serum levels of 25-hydroxy (OH) vitamin D and risks of prediabetes (including 3094 participants). Additionally, the present study included 8 studies (including 865 individuals with prediabetes treated with vitamin D supplementation and 715 patients treated with placebo) to assess differences in therapeutic effects between individuals with prediabetes treated with vitamin D supplementation and those treated with placebo. The present study showed no significant associations between low serum levels of 25(OH) vitamin D and high risk of prediabetes. Additionally, the study showed no significant differences in changes of hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), and homeostatic model assessment of insulin resistance (HOMA-IR) between individuals with prediabetes treated with vitamin D and those patients given placebo, whereas meta-analysis showed significantly greater changes in 2-hour oral glucose tolerance test (2HPG) in individuals with prediabetes treated with vitamin D, compared with individuals with prediabetes treated with placebo. Conclusion: The study supported that low serum levels of 25(OH) vitamin D increased the risk of prediabetes. In addition, vitamin D supplementation improves impaired glucose tolerance in prediabetes. However, more large-scale clinical trials are essential to explore the association between vitamin D and prediabetes.

Total, Bioavailable, and Free 25-Hydroxyvitamin D Equally Associate with Adiposity Markers and Metabolic Traits in Mexican Adults

“…Based on the serum levels of 25(OH)D, vitamin D nutritional status has been classified as deficient (<20 ng/mL), insufficient (21-29 ng/mL), and sufficient (>30 ng/mL) [2]. Recent evidence has shown an association of vitamin D deficiency with several metabolic disturbances such as metabolic syndrome (MetS), high blood pressure (BP), type 2 diabetes (T2D), insulin resistance (IR), and obesity [14][15][16][17][18]. Diverse studies have suggested that vitamin D deficiency could promote adipogenesis and disturb the metabolism involved in energy homeostasis, such as leptin, adiponectin, and resistin [19][20][21].…”

An Open Pilot Study of the Effect and Tolerability of Add-On Multivitamin Therapy in Patients with Intractable Focal Epilepsy

“…Studies on the effects of vitamin D on insulin sensitivity have been inconsistent [34,35]. Although it has been proposed that vitamin D deficiency plays an important role in IR [36], many factors are involved, including age, obesity and the presence of prediabetes as well as other cardiovascular risk factors [37]. Inconsistent results between vitamin E and IR have also been reported [38,39].…”

Effect of Vitamin D Supplementation on Glycemic Control in Prediabetes: A Meta-Analysis

“…A four-year followup study suggested that low levels of serum 25(OH)D might be linked to the increased incidence of prediabetes or T2DM in Chinese individuals [5]. Two meta-analyses observed that the administration of vitamin D led to a reduction in glucose and hemoglobin A1c (HbA1c), regardless of intramuscular injection and oral supplementation [6,7]. Therefore, more randomized controlled trials (RCTs) are needed to explore the association between vitamin D supplementation and prediabetes.…”