Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis

Fu, Ningning; Miao, Mengrong; Li, Ningning; Zeng, Shuang; Zhu, Ruilou; Zhang, Jiaqiang

doi:10.1371/journal.pone.0281313

Cited by 4 publications

(2 citation statements)

References 48 publications

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“…However, novel research, suggests that Vitamin D deficiency is not associated with all-cause 6-month mortality after hip fracture surgery, being more determinants factors the presence of other comorbidities and the patient’s functional status [ 28 ]. On the other hand, a recent meta-analysis has shown that 25-hydroxivitamin D has been related with an increase in the incidence of delirium in hospitalized patients [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Secondary osteoporosis prevention: three-year outcomes from a Fracture Liaison Service in elderly hip fracture patients

González-Quevedo,

Rubia-Ortega,

Sánchez-Delgado

et al. 2024

Aging Clin Exp Res

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Background Hip fractures are the most serious fragility fractures due to their associated disability, higher hospitalization costs and high mortality rates. Fracture Liaison Service (FLS) programs have enhanced the management of osteoporosis-related fractures and have shown their clinical effectiveness. Aims To analyze the effect of the implementation of a FLS model of care over the survival and mortality rates following a hip fracture. Methods We conducted a prospective cohort study on patients over 60 years of age who suffered a hip fracture before and after the implementation of the FLS in our center (between January 2016 and December 2019). Patients were followed for three years after the index date. Mortality, complications and refracture rates were compared between the two groups using a Multivariate Cox proportional hazard model. Results A total of 1366 patients were included in this study (353 before FLS implementation and 1013 after FLS implementation). Anti-osteoporotic drugs were more frequently prescribed after FLS implementation (79.3% vs 12.5%; p < 0.01) and there was an increase in adherence to treatment (51.7% vs 30.2%; p < 0.01). A total of 413 (40.8%) patients after FLS implementation and 141 (39.9%) individuals before (p = 0.47) died during the three-years follow-up period. A second fracture occurred in 101 (10.0%) patients after FLS implementation and 37 (10.5%) individuals before (p = 0.78). Patients after the implementation of the FLS protocol had a lower all cause one-year mortality [adjusted Hazard Ratio (HR) 0.74 (0.57–0.94)] and a decreased risk of suffering a second osteoporotic fracture [adjusted HR 0.54 (0.39–0.75) in males and adjusted HR 0.46 (0.30–0.71) in females]. Conclusions The implementation of a FLS protocol was associated with a lower all-cause one-year mortality rate and a higher survivorship in elderly hip fracture patients. However, no three-year mortality rate differences were observed between the two groups. We also found a reduction in the complication and second-fracture rates.

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Section: Discussionmentioning

confidence: 99%

Secondary osteoporosis prevention: three-year outcomes from a Fracture Liaison Service in elderly hip fracture patients

González-Quevedo,

Rubia-Ortega,

Sánchez-Delgado

et al. 2024

Aging Clin Exp Res

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“…Moreover, vitamin D de ciency, may lead to delirium and PD. Previous MR analysis and cohort studies have found an association between low vitamin D concentrations and the onset of delirium [34][35][36] . Previous studies have extensively documented the markedly high incidence of vitamin D de ciency among individuals suffering from PD and the notable predictive capacity of such de ciency for both the onset and progression of this condition [37][38][39] .…”

Section: Discussionmentioning

confidence: 99%

Causal relationships between delirium and Parkinson’s Disease: a bidirectional two-sample Mendelian randomization study

Bai,

Zhang,

Zhou

et al. 2023

Preprint

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Background Previous observational studies have suggested a notably elevated prevalence of delirium in individuals diagnosed with Parkinson's disease (PD), thereby implying a potential increased susceptibility to delirium among PD patients. However, it is imperative to acknowledge that observational studies inherently possess limitations, rendering it arduous to establish a definitive causal or reverse causal association between delirium and PD. Methods To explore the relationship between delirium and PD, a bidirectional two-sample Mendelian randomization (MR) was conducted using summary statistics obtained from genome-wide association studies. The main analysis was performed using the inverse-variance weighted (IVW) method, with further analyses conducted using MR Egger, weighted median, and weighted mode to ensure accuracy of findings. Additionally, Cochran's Q statistics and MR Egger intercept were utilized to assess heterogeneity and horizontal pleiotropy, respectively. Results According to the results obtained from the IVW model, no compelling evidence was found to support a potential causal association between delirium and PD (IVW: odds ratio [OR]: 0.996, 95% confidence interval [CI] = 0.949–1.043, P = 0.845). Additionally, in the reverse direction, based on the results obtained from the IVW model, no significant evidence was found to support a causal association between PD and delirium (IVW: OR: 1.078, 95%CI = 0.960–1.204, p = 0.225). A sensitivity analysis verified the reliability of the results. Conclusion According to the MR findings, a bidirectional causal relationship between delirium and PD is not observed. It is crucial to conduct further research in clinical practice to investigate the association between delirium and the risk of PD.

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Investigation of total 25-hydroxy vitamin D concentrations and postoperative delirium after major cardiac surgery

Sparling,

Ketigian,

et al. 2024

British Journal of Anaesthesia

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Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis

Cited by 4 publications

References 48 publications

Secondary osteoporosis prevention: three-year outcomes from a Fracture Liaison Service in elderly hip fracture patients

Secondary osteoporosis prevention: three-year outcomes from a Fracture Liaison Service in elderly hip fracture patients

Causal relationships between delirium and Parkinson’s Disease: a bidirectional two-sample Mendelian randomization study

Investigation of total 25-hydroxy vitamin D concentrations and postoperative delirium after major cardiac surgery

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