Association Between Vitamin D Deficiencies in Sarcoidosis with Disease Activity, Course of Disease and Stages of Lung Involvements

Abstract

SummaryBackgroundDespite negative association between 25-hydroxy vitamin D and incidence of many chronic respiratory diseases, this feature was not well studied in sarcoidosis. Current study investigated the association between 25-hydroxy vitamin D deficiency with sarcoidosis chronicity, disease activity, extra-pulmonary skin manifestations, urine calcium level and pulmonary function status in Iranian sarcoidosis patients. Results of this study along with future studies, will supply more effective programs for sarcoidosis treatment.MethodsEighty sarcoidosis patients in two groups of insufficient serum level and sufficient serum level of 25-hydroxy vitamin D were studied. Course of sarcoidosis was defined as acute and chronic sarcoidosis. Pulmonary function test (PFT) was assessed by spirometry. Skin involvements were defined as biopsy proven skin sarcoidosis. 24-hour urine calcium level was used to specify the disease activity. Stages of lung involvements were obtained by CT-scan and chest X-ray. The statistical analyses were evaluated using Statistical Package for the Social Sciences.ResultsA significant negative correlation was obtained between vitamin D deficiency in sarcoidosis patients and disease chronic course and stages two to four of lung involvements. Considering other parameters of the disease and vitamin D deficiency, no significant correlation was detected.ConclusionsIn conclusion, results of the current study implies in the role of vitamin 25(OH)D deficiencies in predicting the course of chronic sarcoidosis. Furthermore, it was concluded that vitamin 25(OH)D deficiency can direct pulmonary sarcoidosis toward stage 2–4 of lung involvements.

The Diagnostic Dilemma of Sarcoidosis: A Case of Acute Hypercalcemia

“…As hypercalcemia is a common electrolyte abnormality, all cases must be thoroughly evaluated with PTH, 25-hydroxyvitamin D, and PTHrP to rule out common etiologies. 1,25-dihydroxyvitamin D testing is key to diagnosis as patients with sarcoidosis can have varying levels of 25-hydroxyvitamin D. A subset of patients may be deficient in 25-hydroxyvitamin D [ 9 ]. Diagnosis of sarcoidosis in hypercalcemic patients is difficult as the presentation may mimic other granulomatous diseases and malignancies.…”

Evaluation of the Reliability and Validity of the Persian Version of the Fatigue Assessment Scale in Iranian Sarcoidosis Patients

“…Sarcoidosis is a chronic inflammatory disease with an unknown cause with non-caseating granulomas manifestations in different organs [ 1 ] [ 2 ]. The outbreak varies from one region to another, and the general prevalence is about 5-40 cases per 100,000 [ 3 ]. Sarcoidosis occurs at all ages, but the highest incidence in patients has been observed in the second and sixth decades of their life [ 4 ].…”

“…Furthermore, additional pulmonary involvements occur in 25-30% of patients [ 2 ] [ 3 ]. Fatigue is one of the common symptoms of sarcoidosis, which occurs in about 50-70% of patients.…”

“…Fatigue is one of the common symptoms of sarcoidosis, which occurs in about 50-70% of patients. The definitive cause of fatigue is unknown and is influenced by numerous factors [ 3 ] [ 5 ]. This symptom is associated with many chronic physical illnesses, such as multiple sclerosis, Parkinson’s disease, rheumatoid arthritis, and psychiatric disorders such as depression [ 6 ].…”

“…FAS questionnaire is a one-dimensional scale for fatigue testing and consists of 10 questions that examine five physical fatigue and five mental health issues. The whole amount of fatigue and its severity is presented by a total score is between 10 and 50 [ 3 ] [ 12 ]. This study aimed to assess the fatigue manifestations in Iranian sarcoidosis patients.…”