Association between vitamin D deficiency and pre‐existing resistance‐associated hepatitis C virus NS5A variants

Okubo, Tomomi; Atsukawa, Masanori; Tsubota, Akihito; Shimada, Noritomo; Abe, Hiroshi; Yoshizawa, Kai; Arai, Taeang; Nakagawa, Ai; Itokawa, Norio; Kondo, Chisa; Aizawa, Yoshifusa; Iwakiri, Katsuhiko

doi:10.1111/hepr.12784

Cited by 4 publications

(1 citation statement)

References 40 publications

(125 reference statements)

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“…Finally, there are other associations and mechanism of HCV extrahepatic manifestations. Several studies correlate a deficiency of vitamin D in the setting of HCV chronic infection with the development of vasculitis and NHL [ 58 , 59 , 60 ]. It has been proposed that vitamin D plays a pivotal role in immune system modulation by facilitating the generation of regulatory T-cells and reducing the levels of pro-inflammatory cytokines like Th1 and Th17 cytokines, as well as inhibiting B-cell differentiation.…”

Section: Mechanism Of Chronic Hepatitis C Virus Infection and Extrahe...mentioning

confidence: 99%

Chronic Hepatitis C Virus Infection, Extrahepatic Disease and the Impact of New Direct-Acting Antivirals

Méndez-Sánchez,

Coronel-Castillo,

Ramírez-Mejía

2024

Pathogens

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Chronic hepatitis C virus infection is an important cause of liver cirrhosis, hepatocellular carcinoma and death. Furthermore, it is estimated that about 40–70% of patients develop non-hepatic alterations in the course of chronic infection. Such manifestations can be immune-related conditions, lymphoproliferative disorders and metabolic alterations with serious adverse events in the short and long term. The introduction of new Direct-Acting Antivirals has shown promising results, with current evidence indicating an improvement and remission of these conditions after a sustained virological response.

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Section: Mechanism Of Chronic Hepatitis C Virus Infection and Extrahe...mentioning

confidence: 99%

Chronic Hepatitis C Virus Infection, Extrahepatic Disease and the Impact of New Direct-Acting Antivirals

Méndez-Sánchez,

Coronel-Castillo,

Ramírez-Mejía

2024

Pathogens

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Efficacy and safety of ledipasvir/sofosbuvir for genotype 1b chronic hepatitis C patients with moderate renal impairment

et al. 2018

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Vitamin D deficiency in hepatitis C virus infection: what is old? what is new?

Jin

Chen

Sheng

2018

European Journal of Gastroenterology &Amp; Hepatology

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In the past few years, a growing body of clinical evidence has highlighted the risk of vitamin D deficiency in patients with chronic hepatitis C and that vitamin D levels are associated with the course of hepatitis C virus (HCV) infection, adverse effects, and treatment response to peginterferon/ribavirin. Recently, studies have found that vitamin D status is related to drug resistance and increased risk of infection in patients with liver cirrhosis. Vitamin D-related gene polymorphisms have been found to explain the interactions between vitamin D deficiency and HCV infection, offering a new perspective toward understanding the current problems such as the development of insulin resistance and racial differences in sustained virological response. Studies have been conducted to determine whether vitamin D supplementation as an adjuvant yields a better result compared with traditional HCV treatment. Here, we provide a brief review of the past and present knowledge of vitamin D in HCV infection.

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Association between vitamin D deficiency and pre‐existing resistance‐associated hepatitis C virus NS5A variants

Abstract: We showed that RAVs at the NS5A region are associated with vitamin D deficiency and elderly age, which may have a negative influence on innate/adaptive immune responses to hepatitis C virus infection.

Cited by 4 publications

References 40 publications

Chronic Hepatitis C Virus Infection, Extrahepatic Disease and the Impact of New Direct-Acting Antivirals

Chronic Hepatitis C Virus Infection, Extrahepatic Disease and the Impact of New Direct-Acting Antivirals

Efficacy and safety of ledipasvir/sofosbuvir for genotype 1b chronic hepatitis C patients with moderate renal impairment

Vitamin D deficiency in hepatitis C virus infection: what is old? what is new?

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