Association between Vitamin D Deficiency and Primary Cesarean Section

Merewood, Anne; Mehta, Supriya D.; Chen, Thomas; Bauchner, Howard; Holick, Michael F.

doi:10.1210/jc.2008-1217

Cited by 331 publications

(217 citation statements)

References 35 publications

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“…In recent years, studies associating vitamin D deficiency and insufficiency with an increased risk of adverse outcomes such as insulin resistance, cardiovascular disease, colon and breast cancer, inflammatory diseases, and mortality have cumulated (1)(2)(3)(4)(18)(19)(20). Of particular relevance to women of reproductive age is the association between vitamin D deficiency and insufficiency and an increased risk of gestational diabetes, preeclampsia, and requirement of a primary C section (9,21,22). Low maternal serum 25OHD levels during pregnancy may also result in short-term adverse outcomes for the fetus (e.g.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and predictors of vitamin D insufficiency in women of reproductive age living in northern latitude

Gagnon

Baillargeon

Desmarais

et al. 2010

European Journal of Endocrinology

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Objective: This study assessed the prevalence of vitamin D deficiency (serum 25-hydroxyvitamin D (25OHD) %50 nmol/l) and insufficiency (serum 25OHD 51-74 nmol/l) during summer and the predictors of serum 25OHD in young women of reproductive age. Design: Cross-sectional study. Methods: Between May and September 2006, 153 healthy, ambulatory and essentially Caucasian women, aged 18-41 years, were recruited. Serum 25OHD and parathyroid hormone (PTH) levels were measured, and questionnaires were evaluated. Results: About 3.9% of women had serum 25OHD %50 nmol/l with an additional 26.8% in the insufficient range. Most women (56.9%) had their blood sampled in September. Month of blood collection significantly influenced serum 25OHD. Body mass index (BMI) was inversely associated with serum 25OHD, while traveling to a warmer climate during winter/spring and using oral contraceptive pills (OCP) were associated with higher serum 25OHD. Sunscreen was used by 77.8% of women, but only 3.3% reported consuming vitamin D supplements. BMI, serum PTH, travel to a warmer climate, and OCP use were independently and significantly associated with serum 25OHD, after adjustment for the month of sampling, and explained 40% of the variance in serum 25OHD. Conclusions: In Canada, the prevalence of vitamin D insufficiency is relatively high (30%) during summer in healthy women of reproductive age. Given the expected decrease in serum 25OHD during winter and the low consumption of vitamin D supplements, a high prevalence of vitamin D deficiency and insufficiency is to be anticipated during winter, except maybe for those traveling to a warmer climate.

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Section: Discussionmentioning

confidence: 99%

Prevalence and predictors of vitamin D insufficiency in women of reproductive age living in northern latitude

Gagnon

Baillargeon

Desmarais

et al. 2010

European Journal of Endocrinology

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“…(Уровень доказательности B I. ) Выраженный дефицит витамина D с уровнями 25(OH)D менее 10 нг/мл может встречаться до 30% у беременных белых женщин в европейских странах [107][108][109], и до 59-84% беременных женщин дру-гой этнической принадлежности [109]. Уровень же ниже современных целевых значений в 30 нг/мл на-блюдался у 86-88% беременных женщин [107][108][109].…”

Section: лицам старше 50 лет для профилактики дефи-цита витамина D реunclassified

“…В III триместре начина-ется кальцификация скелета, что значимо повыша-ет потребность в кальции [4], которая восполняется повышенной продукцией 1,25(ОН) 2 D почками ма-тери и плацентой, что увеличивается постепенно к III триместру. Результаты проведенных исследова-ний показали, что дефицит витамина D у беремен-ных женщин связан с повышенным риском пре-эклампсии [111,112], гестационного диабета [113], кесарева сечения [107], остеопении и остеопороза [114].…”

Section: лицам старше 50 лет для профилактики дефи-цита витамина D реunclassified

“…Результаты исследований показали, что доза витамина D 600, предложенная исходно Ин-ститутом Медицины США, не может предупреждать формирование дефицита витамина D у беременных женщин [107,108]. Необходимо отметить, что боль-шая часть мультивитаминов для беременных и кор-мящих грудью женщин, вопреки ожидаемому, со-держит намного меньше рекомендуемого мини-мального потребления витамина D (0-500 МЕ, в среднем 305 МЕ) и кальция (0-200 мг, в среднем -80 мг), что делает очень важным дополнительный прием препаратов витамина D и кальция (РЛС http://www.rlsnet.ru/mnn_index_id_4587.htm).…”

Section: лицам старше 50 лет для профилактики дефи-цита витамина D реunclassified

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Russian Association of Endocrinologists recommendations for diagnosis, treatment and prevention of vitamin D deficiency in adults

Pigarova¹,

Рожинская²,

Белая³

et al. 2016

Probl Endokrinol (Mosk)

144

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Background. Adequate intake of vitamin D and its concentration in serum is important for the health of bones and calcium-phosphorus metabolism and for the optimal functioning of many organs and tissues. Most epidemiological studies have shown that vitamin D deficiency is widespread among the population in Russian Federation.Material and methods. We reviewed relevant literature on the epidemiology of insufficiency and deficiency, skeletal and extraskeletal effects of vitamin D and summarized recommendations for the diagnosis, prevention and treatment of vitamin D deficiency in the general population, which were subsequently discussed and amended in conjunction with leading endocrinologists of the Russian Federation who are experts in this subject.Results. The optimal concentration of 25(OH)D in the serum as the best indicator of vitamin D body stores is recognized as 30—100 ng/ml (75—250 nmol/l), insufficiency — from 20 to 30 ng/ml (50 to 75 nmol/l), deficiency — less than 20 ng/ml (less than 50 nmol/l). In prevention and treatment it is recommended to stick to the target serum levels of 25(OH)D in the range of 30—60 ng/ml (75—150 nmol/l). We’ve developed a general practice recommendations for the prevention, diagnosis and treatment of vitamin D deficiency in adults, including pregnant and lactating women, persons over 50 years old and subjects suffering from various diseases affecting the metabolism of vitamin D.Conclusions. Increased sufficiency of vitamin D in the population should be included as one of the priorities of modern healthcare due to proven preventive health effects on the musculoskeletal system and the potential positive impact on many socially significant diseases. This publication is a detailed version of the Federal Guideline.

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“…Fetal Vitamin D concentrations are up to 20% lower than maternal as measured in cord blood. Vitamin D deficiency during pregnancy is linked with preeclampsia [34], gestational diabetes mellitus, preterm labour [35] [36] and an increased risk for caesarean section delivery [37]. The importance of Vitamin D for fetal & infant skeletal development has long been recognized.…”

Section: The Significance Of Vitamin D In Pregnancymentioning

confidence: 99%

Vitamin D Efficiency in Pregnancy: An Updated Viewpoint in Indian Scenario

Maladkar¹,

Sankar²,

Kamat³

2015

IJCM

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Association between Vitamin D Deficiency and Primary Cesarean Section

Abstract: Vitamin D deficiency was associated with increased odds of primary cesarean section.

Cited by 331 publications

References 35 publications

Prevalence and predictors of vitamin D insufficiency in women of reproductive age living in northern latitude

Prevalence and predictors of vitamin D insufficiency in women of reproductive age living in northern latitude

Russian Association of Endocrinologists recommendations for diagnosis, treatment and prevention of vitamin D deficiency in adults

Vitamin D Efficiency in Pregnancy: An Updated Viewpoint in Indian Scenario

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