Association between vitamin D receptor gene FokI polymorphism and atopic childhood bronchial asthma

Nabih, Enas Samir; Kamel, Terez Boshra

doi:10.1016/j.ejcdt.2014.02.012

Cited by 10 publications

(12 citation statements)

References 23 publications

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“…In contrast, the Egyptian population showed significant protective association of major allele in homozygous form with asthmatics (OR 0.28 (0.17,0.44). There was also significant association of minor allele in homozygous with OR 2.32 (1.40, 3.83) and in heterozygous form with OR 1.75 (1.14, 2.68) [ 12 , 25 , 29 , 30 , 31 , 32 , 33 , 34 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

Association of vitamin D gene polymorphisms in children with asthma - A systematic review

Ashok

Kirubakaran

Saraswathy

2020

Heliyon

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Introduction The association of Vitamin D and children with asthma is known and there are several individual studies on Vitamin D polymorphisms. However, systematic reviews on all vitamin D associated gene polymorphisms have not been done in children with asthma. Objective To investigate the association of Vitamin D associated gene polymorphisms and asthma in children (0–18 years) by systematic review and meta-analytic approach. Methods Our search included 20 full text articles of which 15 were case control studies and 5 used family based linkage disequilibrium method. Total of 2491cases and 3682 controls were included in case control studies, with mean age of 9.58 years and 10.16 years respectively. Quantitative and qualitative analysis were done. Results Quantitative analysis revealed significant association with protective effect of Apa1 polymorphism in allele (OR 0.81 (0.71,0.91) and homozygous major form (OR 0.83 (0.70,0.98) and Taq 1 minor allele in homozygous form (OR 0.73 (0.58,0.92) in children with asthma. However, the minor allele of Apa1(OR 1.21 (1.07,1.37), Bsm 1 in heterozygous (OR 1.35 (1.07,1.71) and homozygous minor form (OR 1.95 (1.59,2.39), major allele of Fok1(OR1.34 (1.17,1.52) and Taq1 (OR 1.22 (1.08,1.38) were found to be increasing the odds of asthma. Ethnic variations were noted in subgroup analysis. Qualitative analysis of the polymorphisms of the Vitamin D associated metabolic genes also showed significant associations. Conclusion Our review shows significant associations with VDR polymorphisms - Apa1, Bsm1, Fok 1, Taq 1, polymorphisms of Vitamin D metabolic genes – CYP27A1, CYP 2R1, CYP 24A1, GC and genes related to Vitamin D response element (VDRE) in children with asthma. Conducting large studies involving various ethnic regions will strengthen our knowledge on the association and aid in targeted interventions for control of asthma in children.

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Section: Resultsmentioning

confidence: 99%

Association of vitamin D gene polymorphisms in children with asthma - A systematic review

Ashok

Kirubakaran

Saraswathy

2020

Heliyon

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“…In one study, FokI was not correlated with asthma diagnosis, but its C allele was associated with greater baseline airway obstruction . In another study, they found association of FokI and risk of atopic asthma . ApaI and TaqI were associated with asthma in two studies , but no relationship with the required treatment has been reported.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D levels and vitamin D receptor gene polymorphisms in asthmatic children: a case–control study

Einisman

Reyes

Angulo

et al. 2015

Pediatric Allergy Immunology

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“…Variants within VDR, CYP2R1, and CYP24A1 genes have been shown to be associated with asthma in the Caucasians[2342] and Egyptians. [43] Some previous studies have raised the susceptibility of VDR gene to be a candidate gene for childhood asthma,[4445] and it has been shown that VDR influences asthma and allergy susceptibility in a complex manner. [23] A recent study of the VDR gene in Caucasian French Canadian families demonstrated associations between six alleles (rs3782905C, rs1540339A, rs2239185C, rs2239185G, BsmIG, and TaqIT) and asthma and four alleles (rs2239185C, BsmIG, ApaIC, and TaqIT) and atopy ( P < 0.05), respectively.…”

Section: Discussionmentioning

confidence: 99%

“…[53] Some previous authors have also suggested that FF genotype of FokI (rs2228570) in VDR gene is protective for asthma. [2344] Interestingly, a recent study in Serbian patients has demonstrated that FF genotype and F allele of FokI (rs2228570) in VDR gene have a protective effect on asthma. [54] Likewise, our study has demonstrated that (rs2228570, C > T) is protective for asthma.…”

Section: Discussionmentioning

confidence: 99%

Effects of genetic polymorphisms in Vitamin D metabolic pathway on Vitamin D level and asthma control in South Indian patients with bronchial asthma

et al. 2019

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Objectives:The study was designed to evaluate the single-nucleotide polymorphisms (SNPs) of genes involved in Vitamin D actions (rs2228570) and metabolic pathways (rs2248137 and rs10766197) and their associations with serum 25-hydroxy Vitamin D (25(OH)D) level and asthma control in South Indian patients with bronchial asthma.Materials and Methods:One hundred and two patients of South Indian origin with bronchial asthma either naive to inhaled corticosteroids (ICSs) or not receiving ICS for ≥1 month were included and were treated with ICS (beclomethasone 200 μg twice daily) for 8 weeks. One hundred and one unrelated healthy South Indians were used as controls. Pulmonary function test and fractional exhaled nitric oxide were used to assess asthma control. Serum 25(OH)D levels (chemiluminescence immunoassay) and SNPs in Vitamin D pathway (real-time polymerase chain reaction) were assessed. The associations of SNPs and serum 25(OH)D with asthma control was determined using linear regression. All analyses were performed using SPSS (version 19) and “SNPStats.” P < 0.05 was considered as statistically significant.Results:Vitamin D receptor (VDR) polymorphism (rs2228570) was found to be protective against asthma (P = 0.022), while there were no significant associations between the other two SNPs and asthma. Similarly, poor correlation and insignificant associations between the SNPs and serum 25(OH)D levels were observed in both cases and controls. There were also insignificant associations between the SNPs and asthma control.Conclusion:VDR polymorphism (rs2228570) was found to be protective against asthma in South Indians, while other genes involved in the metabolic pathway of Vitamin D did not show associations with asthma.

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Association between vitamin D receptor gene FokI polymorphism and atopic childhood bronchial asthma

Cited by 10 publications

References 23 publications

Association of vitamin D gene polymorphisms in children with asthma - A systematic review

Association of vitamin D gene polymorphisms in children with asthma - A systematic review

Vitamin D levels and vitamin D receptor gene polymorphisms in asthmatic children: a case–control study

Effects of genetic polymorphisms in Vitamin D metabolic pathway on Vitamin D level and asthma control in South Indian patients with bronchial asthma

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