Association Between Vitamin K and the Metabolic Syndrome: A 10-Year Follow-Up Study in Adults

Dam, Veerle; Dalmeijer, Geertje W.; Vermeer, Cees; Drummen, Nadja E.A.; Knapen, Marjo H. J.; Schouw, Yvonne T. van der; Beulens, Joline W.J.

doi:10.1210/jc.2014-4449

Cited by 57 publications

(54 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our data confirmed high plasma dp-ucMGP levels in advanced non-dialysis CKD patients when compared with the levels measured in healthy subjects [20,21], whereas they were lower than those in previously reported in HD populations [16,22,23]. In the present study we showed a strong inverse association between kidney function assessed by eGFR and plasma dp-ucMGP concentrations in non-dialysis patients with CKD stage 4-5.…”

Section: Discussionsupporting

confidence: 90%

“…Likewise, Dalmeijer et al did not observe any changes in lipid profile during vitamin K2 supplementation among healthy men and postmenopausal women [20]. Dam et al recently reported that high intake of menaquinone was associated with lower incidence of metabolic syndrome and showed an association between triglycerides and dp-ucMGP concentrations [21].…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Plasma Desphospho-Uncarboxylated Matrix Gla Protein as a Marker of Kidney Damage and Cardiovascular Risk in Advanced Stage of Chronic Kidney Disease

Kurnatowska

Grzelak

Masajtis-Zagajewska

et al. 2016

Kidney Blood Press Res

Self Cite

View full text Add to dashboard Cite

Background/Aims: Desphospho-uncarboxylated matrix Gla protein (dp-ucMGP) is formed as a result of vitamin K insufficiency. The aim of this study was to investigate the association between plasma dp-ucMGP, kidney function and cardiovascular risk factors before and after 9-months substitution of vitamin K2 in non-dialysis patients with chronic kidney disease (CKD) stage 4 and 5. Methods: 38 CKD patients were supplemented for 270±12 days with 90 µg vitamin K2 and 10 µg cholecalciferol or 10 µg cholecalciferol alone. At baseline and at follow-up circulating calcium, phosphate, lipids, hemoglobin, albumin and total protein, dp-ucMGP, osteoprotegerin, fetuin A, osteocalcin and fibroblast grown factor 23 (FGF-23) were assessed. Proteinuria was assessed in the first morning void. Results: Baseline plasma dp-ucMGP was 1018.6±498.3 pmol/l and was significantly higher in patients at stage 5 CKD (1388.3 ±505.4 pmol/l) than at stage 4 (885.1±419.7 pmol/l), p=0.04. Vitamin K2 supplementation resulted in a decrease of dp-ucMGP level by 10.7%. Plasma dp-ucMGP was positively associated with proteinuria, serum creatinine, PTH and FGF-23; and inversely associated with glomerular filtration rate, serum hemoglobin and albumin. Conclusions: High dp-ucMGP level, reflecting a poor vitamin K status seems to be associated with kidney damage and may be also a marker of cardiovascular risk in CKD patients. Supplementation with vitamin K2 may improve the carboxylation status of MGP.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 96%

Plasma Desphospho-Uncarboxylated Matrix Gla Protein as a Marker of Kidney Damage and Cardiovascular Risk in Advanced Stage of Chronic Kidney Disease

Kurnatowska

Grzelak

Masajtis-Zagajewska

et al. 2016

Kidney Blood Press Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…Hypotensive drugs were also used. [36] . Dutch older adults (aged 40-80 years, 400 men, 402 women) were followed for 8.14 years.…”

Section: Involvement Of Vitamin K 2 -Dependent Pathways In Dmmentioning

confidence: 99%

“…17 ). Matrix Gla protein is also γ-carboxylated through a vitamin K 2 -dependent processes, and the plasma level of uc-matrix Gla protein was positively associated with MetS [36] . In older adults, elevated levels of c-Ocn and total Ocn, but not of uc-Ocn, were associated with lower insulin resistance [37] ( fig.…”

Section: Involvement Of Vitamin K 2 -Dependent Pathways In Dmmentioning

confidence: 99%

Medicines and Vegetable Oils as Hidden Causes of Cardiovascular Disease and Diabetes

Okuyama

Langsjoen²,

Ohara

et al. 2016

Pharmacology

View full text Add to dashboard Cite

Background: Positive associations have been observed between cardiovascular disease (CVD) and type 2 diabetes mellitus (DM), but their causal relationship has not been clarified. Nevertheless, guidelines from relevant medical societies recommend using cholesterol lowering medication (statin) for both types of patients. Medicines with several different action mechanisms have been developed, and the effectiveness of different lifestyle modifications has been studied extensively for the prevention of DM, which was successful in improving clinical marker status in relatively short-term treatments, but none have been shown to be effective in improving long-term outcomes (mortality from CVD and all causes). Summary: Statin-induced suppression of prenyl intermediates in the cholesterol biosynthetic pathway has been linked to stimulated atherosclerosis and heart failure. On the other hand, certain types of vegetable oil and hydrogenated oil shortened the survival of stroke-prone spontaneously hypertensive rats by decreasing platelet number, increasing hemorrhagic tendency and damaging kidney functions, which could not be accounted for by their fatty acid and phytosterol compositions. These vegetable oils and medicines such as statin and warfarin share, in part, a common mechanism to inhibit vitamin K₂-dependent processes, which was interpreted to lead to increased onset of CVD, DM, chronic kidney disease, bone fracture and even mental disorder. Impaired vitamin K₂-dependent processes by some types of vegetable oils and medicines, but not plasma high low density lipoprotein cholesterol, were proposed as the cause of CVD, DM and other lifestyle-related diseases. High n-6/n-3 fatty acid ratio of ingested foods, but not animal fats, was emphasized to be another risk factor for many of the diseases described above. Key Messages: To date, no randomized controlled trials (RCTs) have been performed to prove the above interpretation. However, the opposite types of RCT trials have been performed by increasing the intake of high-linoleic vegetable oils and reducing that of animal fats, which resulted in increased CVD and all-cause mortality. The amounts of these vegetable oils to exhibit adverse effects in animal studies are not huge (<6 energy %), which should not be overlooked nor disregarded.

show abstract

“…Several studies have tried to shed light on the dietary determinant of MetS. 5, 6, 7, 8, 9, 10, 11, 12 Some of their limitations include relatively small sample size of the studies, 5, 7, 8, 10 lack of diversity of the populations, 12 limitation in generalizability of the findings 12 and single-nutrient approach, 6, 7, 8, 9, 10, 11 whereas diet by definition is complex. As a result of more recognition of limitations inherent to the single-nutrient approach, dietary pattern analysis has emerged as an attractive alternative approach for examining the effect of overall diet reflecting the real-world eating behaviors of the population.…”

Section: Introductionmentioning

confidence: 99%

Link of dietary patterns with metabolic syndrome: analysis of the National Health and Nutrition Examination Survey

2017

View full text Add to dashboard Cite

Background:Population-based interventions aimed at halting the increasing prevalence of metabolic syndrome (MetS) require thorough understanding of dietary interplays. Objective is to identify the independent dietary nutrients associated with MetS and its components using dietary pattern identification and the single-nutrient approaches in The United States.Methods:This is a cross-sectional observation. Participants are selected from the National Health and Nutrition Examination Survey (NHANES) with available dietary intake, biochemical and anthropometrical data from 2001 to 2012. Exposure is diet obtained from 24-h dietary recall. Main outcome measure is MetS and its components.Results:Overall, 23 157 eligible individuals including 6561 with MetS were included in the final analysis. Using principle component analysis, we identified three food patterns that explained 50.8% of the variance of the dietary nutrient consumption. The highest quartile of the factor score representative of saturated/monounsaturated fatty acids or the first dietary pattern was associated with 1.27-fold (95% confidence interval (CI): 1.10–1.46, P=0.001) higher odds of association with MetS when compared with the first quartile. The second pattern representative of vitamins and trace elements had an odds ratio of 0.79 (95% CI: 0.70–0.89, P<0.001) for association with MetS, and the third pattern representative of polyunsaturated fatty acids did not have any association with MetS. The nutrient-by-nutrient approach showed that mild alcohol intake and lower consumption of total saturated fatty acids and sodium were associated with lower risk of MetS.Conclusions:Application of multiple complementary analytic approaches reveals more comprehensive dietary determinants of MetS and its components as potential intervening targets.

show abstract

Association Between Vitamin K and the Metabolic Syndrome: A 10-Year Follow-Up Study in Adults

Abstract: This study shows that a high intake of menaquinones and high vitamin K status are associated with a lower occurrence of MetS.

Cited by 57 publications

References 36 publications

Plasma Desphospho-Uncarboxylated Matrix Gla Protein as a Marker of Kidney Damage and Cardiovascular Risk in Advanced Stage of Chronic Kidney Disease

Plasma Desphospho-Uncarboxylated Matrix Gla Protein as a Marker of Kidney Damage and Cardiovascular Risk in Advanced Stage of Chronic Kidney Disease

Medicines and Vegetable Oils as Hidden Causes of Cardiovascular Disease and Diabetes

Link of dietary patterns with metabolic syndrome: analysis of the National Health and Nutrition Examination Survey

Contact Info

Product

Resources

About