Association Between Volatile Sulfur Compounds and Periodontal Disease Progression in Elderly Non‐Smokers

Makino, Yuka; Yamaga, Takayuki; Yoshihara, Akihiro; Nohno, Kaname; Miyazaki, Hideo

doi:10.1902/jop.2011.110275

Cited by 25 publications

(23 citation statements)

References 23 publications

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“…The CH 3 SH and H 2 S gases are the main VSCs in intra-oral halitosis 1 , and their toxicity is associated with the development of periodontal disease 15 , 16 , 29 . Tea tree oil was able to inhibit the growth of P. gingivalis W83 and P. endodontalis , and the production of VSCs.…”

Section: Discussionmentioning

confidence: 99%

In vitro effects of Melaleuca alternifolia essential oil on growth and production of volatile sulphur compounds by oral bacteria

Graziano¹,

Calil²,

Sartoratto³

et al. 2016

J. Appl. Oral Sci.

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Objective Halitosis can be caused by microorganisms that produce volatile sulphur compounds (VSCs), which colonize the surface of the tongue and subgingival sites. Studies have reported that the use of natural products can reduce the bacterial load and, consequently, the development of halitosis. The aim of this study was to evaluate the antimicrobial activity of the essential oil of Melaleuca alternifolia on the growth and volatile sulphur compound (VSC) production of oral bacteria compared with chlorhexidine.Material and Methods The effects of these substances were evaluated by the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) in planktonic cultures of Porphyromonas gingivalis and Porphyromonas endodontalis. In addition, gas chromatography analyses were performed to measure the concentration of VSCs from bacterial cultures and to characterize M. alternifolia oil components.Results The MIC and MBC values were as follows: M. alternifolia - P. gingivalis (MIC and MBC=0.007%), P. endodontalis (MIC and MBC=0.007%=0.5%); chlorhexidine - P. gingivalis and P. endodontalis (MIC and MBC=1.5 mg/mL). M. alternifolia significantly reduced the growth and production of hydrogen sulfide (H2S) by P. gingivalis (p<0.05, ANOVA-Dunnet) and the H2S and methyl mercaptan (CH3SH) levels of P. endodontalis (p<0.05, ANOVA-Dunnet). Chlorhexidine reduced the growth of both microorganisms without altering the production of VSC in P. endodontalis. For P. gingivalis, the production of H2S and CH3SH decreased (p<0.05, ANOVA-Dunnet).Conclusion M. alternifolia can reduce bacterial growth and VSCs production and could be used as an alternative to chlorhexidine.

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Section: Discussionmentioning

confidence: 99%

In vitro effects of Melaleuca alternifolia essential oil on growth and production of volatile sulphur compounds by oral bacteria

Graziano¹,

Calil²,

Sartoratto³

et al. 2016

J. Appl. Oral Sci.

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“…A review paper published in 2001, and a number of studies conducted recently, indicated a significant association between periodontal disease and halitosis (Morita and Wang, ; Lee et al , ; Liu et al , ; Quirynen et al , ; Makino et al , ; Apatzidou et al , ), However, some studies have concluded that there is no significant association between the two (Bosy et al , ; Stamou et al , ). In a study conducted by Liu and colleagues, tongue coating was the leading variable that correlated with VSC values in the final logistic regression (Liu et al , ).…”

Section: Discussionmentioning

confidence: 99%

Characteristics of patients complaining of halitosis and factors associated with halitosis

Tang

Chen

et al. 2013

Oral Diseases

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“…High levels of MM and H 2 S were also reported in periodontitis patients by Yaegaki & Sanada (1992 a,b). In addition, elevated VSC levels have been linked to progression of periodontitis (Makino et al 2012). …”

Section: Periodontal Conditions and Intra-oral Halitosismentioning

confidence: 99%

The effect of periodontal therapy on intra‐oral halitosis: a case series

Ademovski

Mårtensson

Persson

et al. 2016

J Clinic Periodontology

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Aim The aim of this study was to evaluate the effects of non‐surgical periodontal therapy on intra‐oral halitosis 3 months after therapy. Material and methods Sixty‐eight adults with intra‐oral halitosis were included in a case series. Intra‐oral halitosis was evaluated at baseline, and at 3 months after treatment using the organoleptic scores (OLS), Halimeter®, and a gas chromatograph. Results Significant reductions for OLS (p < 0.01), total sum of volatile sulphur compounds (T‐VSC) (p < 0.01) and methyl mercaptan (MM) (p < 0.05) values were found after treatment. Hydrogen sulphide (H2S) levels were not significantly reduced. The numbers of probing pockets 4 mm, 5 mm and 6 mm were significantly reduced as a result of therapy (p < 0.001). Bleeding on probing (BOP) and plaque indices were also significantly reduced (p < 0.001). For the 34 individuals with successful periodontal treatment (BOP<20% and a ≥50% reduction of total pocket depth) reductions in OLS (p < 0.01) and T‐VSC scores (p < 0.01) were found. Eleven individuals were considered effectively treated for intra‐oral halitosis presenting with a T‐VSC value <160 ppb, a H2S value <112 ppb and a MM value <26 ppb. Conclusion Non‐surgical periodontal therapy resulted in reduction of OLS, MM and T‐VSC values 3 months after therapy. Few individuals were considered as effectively treated for intra‐oral halitosis.

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Association Between Volatile Sulfur Compounds and Periodontal Disease Progression in Elderly Non‐Smokers

Abstract: VSC measurements were significantly associated with periodontal disease progression in a non-smoking dentulous elderly population. This suggests that VSC measurements are useful for the diagnosis of periodontal disease progression.

Cited by 25 publications

References 23 publications

In vitro effects of Melaleuca alternifolia essential oil on growth and production of volatile sulphur compounds by oral bacteria

In vitro effects of Melaleuca alternifolia essential oil on growth and production of volatile sulphur compounds by oral bacteria

Characteristics of patients complaining of halitosis and factors associated with halitosis

The effect of periodontal therapy on intra‐oral halitosis: a case series

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