Association between x-ray repair cross-complementing group 3 (XRCC3) genetic polymorphisms and papillary thyroid cancer susceptibility in a Chinese Han population

Yuan, Kai; Huo, Meiling; Sun, Yong; Wu, Hongyan; Chen, Hongqiang; Wang, Yulong; Fu, Rongzhan

doi:10.1007/s13277-015-3882-4

Cited by 8 publications

(14 citation statements)

References 35 publications

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“…In line with our results, several studies provided evidence that there was no significant association between the XRCC2-rs3218536 polymorphism and thyroid cancer [20,21]. Similarly, meta-analyses showed that there was no significant association between SNP of rs3218536 and risk of breast cancer under any genetic models [6,41]. However, the rs3218536 polymorphism could be a genetic adjuster for ovarian and colorectal cancer patients [42,43].…”

Section: Discussionsupporting

confidence: 89%

“…As suggested by earlier studies, polymorphisms of these genes are related to thyroid cancer risk [6,[20][21][22][23][24]. However, no conclusive result has been reported due to the conflicting findings among different studies.…”

Section: Introductionmentioning

confidence: 93%

“…Differentiated thyroid cancer (DTC) is a popular subtype of thyroid cancer and it accounts for over 90% of all thyroid carcinomas, which includes several other subtypes such as follicular thyroid cancer (FTC) and papillary thyroid carcinoma (PTC) [4][5][6][7]. The incidences of FTC and PTC are two to four times higher in females than that in males, as a consequence, thyroid cancer becomes the eighth most common cancer occurred in females [6,8]. So far, ionizing radiation (IR) is the only established risk factor for thyroid cancer [6,8].…”

Section: Introductionmentioning

confidence: 99%

“…The incidences of FTC and PTC are two to four times higher in females than that in males, as a consequence, thyroid cancer becomes the eighth most common cancer occurred in females [6,8]. So far, ionizing radiation (IR) is the only established risk factor for thyroid cancer [6,8]. However, ionizing radiation does not always trigger thyroid cancer because both environmental agents and genetic factors could exert important roles in thyroid carcinogenesis [3,9].…”

Section: Introductionmentioning

confidence: 99%

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Association Studies Between XRCC1, XRCC2, XRCC3 Polymorphisms and Differentiated Thyroid Carcinoma

Yan¹,

Li²,

Li³

et al. 2016

Cell Physiol Biochem

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Background/Aims: DNA HRR pathway and BER pathway play vital roles in differentiated thyroid cancer (DTC) development, thus we supposed that polymorphisms of XRCC1, XRCC2, XRCC3 DNA repair genes are associated with thyroid cancer risk and progression. Methods: We searched the NCBI database for relevant literatures to determine eight SNPs to be included in our study (XRCC1: rs25487, rs25489, rs1799782; XRCC2: rs3218536; XRCC3: rs1799794, rs56377012, rs1799796, rs861539). Results: SNP of rs25487 was linked with a 53% decrease in DTC risk (OR: 0.47; 95%CI: 0.268-0.82; P = 0.01). For SNP of rs1799782, the homozygous TT genotype indicated a statistically significant 2-fold increased risk of DTC (OR: 2.09; 95%CI: 1.27-3.43; P < 0.001) after multivariate adjustment. For SNP of rs861539, the homozygous TT genotype suggested statistically significant 3-fold increased risk of DTC (OR: 3.02; 95%CI: 1.68-5.42; P < 0.001). No significant association between the other five SNPs and DTC risk. Besides that, female was linked with 47% increase in DTC risk (OR: 1.47; 95%CI: 1.062-2.04; P = 0.02) after multivariate adjustment. Similar results for most of the SNPs were obtained from subgroup analysis by different histological types of DTC. Haplotype analysis revealed that AGC and GGT haplotypes of XRCC1 polymorphisms were associated with DTC. Moreover, results from gene-gene interaction showed that XRCC1-rs25487, XRCC1- rs1799782 and XRCC3- rs861539 variants jointly contributed to a specifically increased risk of DTC, with the combination variant of rs1799782-CT heterozygote and rs861539-TT homozygote exhibiting a higher 3.66-fold risk of DTC (OR: 3.66; 95% CI: 1.476-9.091, P = 0.005). Conclusion: Polymorphisms of XRCC1 (rs25487, rs1799782) and XRCC3 (rs861539), may play a critical role in DTC development and progression. Furthermore, XRCC1 variant can interact with XRCC3 variant to significantly increase DTC susceptibility. Identifying these genetic risk markers could provide evidence for exploring the insight pathogenesis and develop novel therapeutic strategies for DTC.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association Studies Between XRCC1, XRCC2, XRCC3 Polymorphisms and Differentiated Thyroid Carcinoma

Yan¹,

Li²,

Li³

et al. 2016

Cell Physiol Biochem

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“…The product of XRCC3 is a RAD51 paralog necessary for the binding and stabilization of the latter during DNA repair. In our study, the increased risk of rs861539 polymorphism in thyroid cancer is comparable to previous results reporting significant associations with thyroid cancer risk [36-40]. Nevertheless, many studies have found no evident correlation between XRCC3 polymorphisms and thyroid cancer [41, 42].…”

Section: Discussionsupporting

confidence: 89%

Haplotype Based Analysis of XRCC3 Gene Polymorphisms in Thyroid Cancer

Sarwar¹,

Mahjabeen²,

Bashir³

et al. 2017

Cell Physiol Biochem

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Background/Aims: In mammalian cells, XRCC3 plays an important role in the DNA double-strand breaks (DSBs) repair by homologous recombination. Genetic polymorphisms in XRCC3 gene may potentially affect the repair of DSBs and thus confer susceptibility to thyroid cancer. In this study, we used a haplotype-based approach to investigate whether 5 selected SNPs i.e. rs1799796, rs1799794, rs861539, rs709399 and rs861530 of XRCC3 gene are associated with thyroid cancer risk in 456 cancer patients and 400 cancer-free controls. Methods: Genotyping was performed using Allele-specific PCR followed by sequencing. Statistical analysis was performed to analyse gene and haplotype association. Results: After analysis, frequency of mutant genotype/alleles of SNPs (rs1799796, p<0.0001; rs1799794, p<0.0001; rs861539, p<0.001; rs709399, p <0.0001; rs861530, p<0.002) was found significantly higher in thyroid cancer patients compared to controls. Significant associations were found for most of the variant genotypes in SNPs of rs1799794, rs1799796, rs861539, rs861530 and rs709399 in papillary thyroid and follicular cancer patients compared to other histologic subtypes of thyroid carcinoma. Additionally, haplotype analysis revealed that haplotypes, AACGA (p= 0.0005), AGTAA (p= 0.008), GATAA (p= 0.001), GGCAA (p= 0.001) were linked with significant increase in thyroid cancer risk. However, haplotype AGCGG (p= 0.0009) was associated with a significant reduced thyroid cancer risk. Conclusion: Our results suggest that common genetic variants in the XRCC3 gene of DSBR pathway may modulate thyroid cancer risk.

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Polymorphisms in DNA repair genes in gastrointestinal stromal tumours: susceptibility and correlation with tumour characteristics and clinical outcome

Ravegnini

Nannini

Simeon³

et al. 2016

Tumor Biol.

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DNA repair pathways play an essential role in cancer susceptibility by maintaining genomic integrity. This led us to investigate the influence of polymorphisms in the genes coding repair pathway enzymes on gastrointestinal stromal tumours (GIST) susceptibility, tumour characteristics and clinical outcome. We investigated a panel of 20 polymorphisms in 11 genes in 81 cases and 147 controls. The XPD rs13181 wild-type allele and hOGG1 rs1052133 and XPF rs1800067 minor alleles were significantly associated with disease susceptibility. XPA rs1800975 and rs2808668 were associated with tumour size (P = 0.018), metastatic status at onset (P = 0.035) and mitotic index (P = 0.002). With regards to outcome treatment, the XPD rs50872 minor allele had a significant favourable impact on time to progression (TTP). Similarly, the XPC rs2228000 minor allele was correlated with a longer TTP (P = 0.03). On the contrary, the XPC rs2228001 and hOGG1 rs1052133 minor alleles were associated with a diminished TTP (P = 0.005 and P = 0.01, respectively). Regarding OS, we found the presence of at least one hOGG1 (rs1052133) minor allele that had a 60 % lower risk to die compared to the wild-type carriers (P = 0.04). Furthermore, the XRCC3 rs861539 variant allele is associated with a hazard of early death compared with the wild-type genotype (P = 0.04). To the best of our knowledge, this is the first study on polymorphisms in DNA repair genes, belonging to the different pathways, extensively evaluated in GIST patients. Through this multiple candidate gene approach, we report for the first time the significant associations between polymorphisms in DNA repair genes, susceptibility, clinical pathological features and clinical outcome in GIST.

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Association between x-ray repair cross-complementing group 3 (XRCC3) genetic polymorphisms and papillary thyroid cancer susceptibility in a Chinese Han population

Cited by 8 publications

References 35 publications

Association Studies Between XRCC1, XRCC2, XRCC3 Polymorphisms and Differentiated Thyroid Carcinoma

Association Studies Between XRCC1, XRCC2, XRCC3 Polymorphisms and Differentiated Thyroid Carcinoma

Haplotype Based Analysis of XRCC3 Gene Polymorphisms in Thyroid Cancer

Polymorphisms in DNA repair genes in gastrointestinal stromal tumours: susceptibility and correlation with tumour characteristics and clinical outcome

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