Association factor analysis between osteoporosis with cerebral artery disease

Abstract

The purpose of this study was to determine the clinical association factors between osteoporosis and cerebral artery disease in Korean population. Two hundred nineteen postmenopausal women and men undergoing cerebral computed tomography angiography were enrolled in this study to evaluate the cerebral artery disease by cross-sectional study. Cerebral artery disease was diagnosed if there was narrowing of 50% higher diameter in one or more cerebral vessel artery or presence of vascular calcification. History of osteoporotic fracture was assessed using medical record, and radiographic data such as simple radiography, MRI, and bone scan. Bone mineral density was checked by dual-energy x-ray absorptiometry. We reviewed clinical characteristics in all patients and also performed subgroup analysis for total or extracranial/ intracranial cerebral artery disease group retrospectively. We performed statistical analysis by means of chi-square test or Fisher's exact test for categorical variables and Student's t-test or Wilcoxon's rank sum test for continuous variables. We also used univariate and multivariate logistic regression analyses were conducted to assess the factors associated with the prevalence of cerebral artery disease. A two-tailed p-value of less than 0.05 was considered as statistically significant. All statistical analyses were performed using R (version 3.1.3; The R Foundation for Statistical Computing, Vienna, Austria) and SPSS (version 14.0; SPSS, Inc, Chicago, Ill, USA). Of the 219 patients, 142 had cerebral artery disease. All vertebral fracture was observed in 29 (13.24%) patients. There was significant difference in hip fracture according to the presence or absence of cerebral artery disease. In logistic regression analysis, osteoporotic hip fracture was significantly associated with extracranial cerebral artery disease after adjusting for multiple risk factors. Females with osteoporotic hip fracture were associated with total calcified cerebral artery disease. Some clinical factors such as age, hypertension, and osteoporotic hip fracture, smoking history and anti-osteoporosis drug use were associated with cerebral artery disease.

Common mechanisms and holistic care in atherosclerosis and osteoporosis

“…In regard to specific CVD types, each BMD decrease by one SD corresponded to a consecutively increased risk of CV and cerebrovascular disease by 44% and 28%, respectively [59]. In contrast, Jin et al [60] published data from the recent Korean STROBE (Strengthening the Reporting of Observational studies in Epidemiology) study. They could not completely confirm the observed association between cerebrovascular disease and OP, as vertebral or hip BMD was not associated with cerebral arterial disease [60].…”

“…In contrast, Jin et al [60] published data from the recent Korean STROBE (Strengthening the Reporting of Observational studies in Epidemiology) study. They could not completely confirm the observed association between cerebrovascular disease and OP, as vertebral or hip BMD was not associated with cerebral arterial disease [60].…”

Risk of osteoporotic fractures as a consequence of haemophilia: A nationwide population‐based cohort study

“…The primary clinical outcome was newly diagnosed osteoporotic fractures. Furthermore, common comorbidities related to osteoporotic fractures, including diabetes mellitus (DM), chronic kidney disease, autoimmune disease, chronic liver disease, cerebrovascular disease (CVD), and chronic pulmonary diseases (COPD), were compared among the PWH and the controls.…”