Association of − 717 A &gt; G (rs2794521) CRP polymorphism with high cardiovascular risk by C-reactive protein in systemic lupus erythematosus patients

Pesqueda-Cendejas, Karen; Parra‐Rojas, Isela; Meza-Meza, Mónica R; Mora-García, Paulina E; Campos-López, Bertha; Ruiz-Ballesteros, Adolfo I; Montoya‐Buelna, Margarita; Rivera-Escoto, Melissa; Moreno-Ortiz, José Miguel; Bautista-Herrera, Luis A; Cerpa-Cruz, Sergio; Cruz-Mosso, Ulises De la

doi:10.1007/s10067-022-06430-6

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“…1 The SLE etiology is not fully understood; however, environmental and genetic factors have been suggested as responsible for SLE susceptibility and some co-morbidities, such as cardiovascular disease (CVD). 1,2 It is well known that SLE patients present a high prevalence of cardiometabolic disturbances, which could worsen the SLE clinical manifestations and mortality. 3,4 Therefore, identifying environmental and genetic factors that directly or indirectly contribute to SLE pathophysiology is still a challenge.…”

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confidence: 99%

Association of c.+677 C>T (rs1801133) and c.+1298 A>C (rs1801131) MTHFR genetic variants with cardiometabolic and disease risk in systemic lupus erythematosus patients: A cross-sectional study

Pesqueda-Cendejas,

Parra-Rojas,

Campos-López

et al. 2024

Lupus

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Systemic lupus erythematosus (SLE) patients present a high prevalence of cardiometabolic risk, associated with worse clinical manifestations and mortality. Folate, an essential micronutrient that participates in vital immune cellular functions, could positively affect the cardiometabolic and disease risk in SLE, through the methylenetetrahydrofolate reductase (MTHFR) enzyme, which participates in the folate metabolism, where single nucleotide variants (SNVs) have been described as a potential genetic risk factor for SLE. The aim of this study was to determine the association of the c.+677 C>T (rs1801133) and c.+1298 A>C (rs1801131) MTHFR genetic variants with cardiometabolic risk and clinical disease variables in SLE patients. A case-control study was conducted on 394 unrelated Mexican-mestizo women: 199 with SLE according to the 1997 SLE-ACR criteria and 196 control subjects (CS). Folic acid and homocysteine levels were evaluated by immunoassays. Genotyping of MTHFR genetic variants was carried out by allelic discrimination. No significant differences were found for folic acid ( p = .15) and homocysteine serum levels ( p = .59) between groups. According to the CC c.+677 MTHFR genotype, this was associated with low cardiovascular disease (CVD) risk by the Castelli index (OR = 0.42; p = .03) in SLE patients. The TC (OR = 1.3; p = .03) and the TA (OR = 1.6; p < .01) haplotypes from c.+677 C>T plus c.+1298 MTHFR were associated with SLE risk, while the CC MTHFR haplotype (OR = 0.5; p = .01) was found as a non-risk factor for the disease. In conclusion, the TC and the TA MTHFR haplotypes are associated with disease risk; meanwhile, the CC c.+677 MTHFR genotype confers lower cardiometabolic risk in Mexican-mestizo SLE patients.

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