Association of a polymorphism in exon 3 of the IGF1R gene with growth, body size, slaughter and meat quality traits in Colored Polish Merino sheep

Grochowska, Ewa; Lisiak, D.; Akram, Muhammad Zeeshan; Adeniyi, Olusegun O; Lühken, Gesine; Borys, B.

doi:10.1016/j.meatsci.2020.108314

Cited by 9 publications

(6 citation statements)

References 48 publications

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“…The same gene with two SNPs in the intron region was also identified by Yuan et al (2012) in sheep in addition to observations in cattle (Chen et al, 2018). IGF1 gene polymorphisms have been reported consistently in three studies (Grochowska et al, 2021;Li et al, 2021;Meira et al, 2019) in concordance with reports in other species such as cattle (Yang, Zhu, et al, 2022), pigs (Bouquet et al, 2021), and fish (Chandhini et al, 2021) suggesting IGF1 to be a possible marker of growth and FE. Polymorphisms in the intron region of IGF1 was found to be associated with carcass traits such as length of carcass and rib yield (Meira et al, 2019).…”

Section: Other Putative Omics Markers Of Fe Carcass and Meat Quality ...supporting

confidence: 78%

“…Genetic correlations can greatly impact the overall quality of the end product such as differences in meat tenderness, flavor, intramuscular fat contents, and cooking loss (Grochowska et al, 2017(Grochowska et al, , 2019(Grochowska et al, , 2021. Table 6 shows the estimated genetic correlations between various FE traits, carcass quality, and meat quality traits which reveals that there are positive genetic correlations between FE traits such as daily feed intake, ADG, RFI, and FCR suggesting that animals with higher feed intake, faster weight gain, and lower RFI tend to have better feed conversion efficiency.…”

Section: Heritability and Correlations Between Sheep Fe Carcass Quali...mentioning

confidence: 99%

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Insights into the influence of diet and genetics on feed efficiency and meat production in sheep

Chacko Kaitholil,

Mooney,

Aubry

et al. 2023

Animal Genetics

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Feed costs and carcass yields affect the profitability and sustainability of sheep production. Therefore, it is crucial to select animals with a higher feed efficiency and high‐quality meat production. This study focuses on the impact of dietary and genetic factors on production traits such as feed efficiency, carcass quality, and meat quality. Diets promote optimal sheep growth and development and provide sufficient protein can lead to higher‐quality meat. However, establishing an optimized production system requires careful consideration and balance of dietary parameters. This includes ensuring adequate protein intake and feeding diets with higher intestinal absorption rates to enhance nutrient absorption in the gut. The study identifies specific genes, such as Callipyge, Calpastatin, and Myostatin, and the presence of causal mutations in these genes, as factors influencing animal growth rates, feed efficiency, and meat fatty acid profiles. Additionally, variants of other reported genes, including PIGY, UCP1, MEF2B, TNNC2, FABP4, SCD, FASN, ADCY8, ME1, CA1, GLIS1, IL1RAPL1, SOX5, SOX6, and IGF1, show potential as markers for sheep selection. A meta‐analysis of reported heritability estimates reveals that residual feed intake (0.27 ± 0.07), hot carcass weight (0.26 ± 0.05), dressing percentage (0.23 ± 0.05), and intramuscular fat content (0.45 ± 0.04) are moderately to highly heritable traits. This suggests that these traits are less influenced by environmental factors and could be improved through genetic selection. Additionally, positive genetic correlations exist between body weight and hot carcass weight (0.91 ± 0.06), dressing percentage (0.35 ± 0.15), and shear force (0.27 ± 0.24), indicating that selecting for higher body weight could lead to favorable changes in carcass quality, and meat quality.

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Section: Other Putative Omics Markers Of Fe Carcass and Meat Quality ...supporting

confidence: 78%

Section: Heritability and Correlations Between Sheep Fe Carcass Quali...mentioning

confidence: 99%

Insights into the influence of diet and genetics on feed efficiency and meat production in sheep

Chacko Kaitholil,

Mooney,

Aubry

et al. 2023

Animal Genetics

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“…It is well-established that DNA-based inheritance enables the transmission of selected phenotypes across generations either without changes in the DNA sequence through epigenetic inheritance [31] or through functional mutations involving changes in only one base pair (single nucleotide polymorphisms-SNP). Through next-generation sequencing, SNP are valuable for detecting genetic variability and genomic prediction in sheep breeding programs [32], developing breed-specific DNA markers for breed identification [33,34], animal productivity [35], parentage assignment [36,37], forensics [38], and prediction of meat quality traits [39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Next Generation Sequencing of Single Nucleotide Polymorphic DNA-Markers in Selecting for Intramuscular Fat, Fat Melting Point, Omega-3 Long-Chain Polyunsaturated Fatty Acids and Meat Eating Quality in Tattykeel Australian White MARGRA Lamb

Pewan

Otto

Huerlimann

et al. 2021

Foods

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Meat quality data can only be obtained after slaughter when selection decisions about the live animal are already too late. Carcass estimated breeding values present major precision problems due to low accuracy, and by the time an informed decision on the genetic merit for meat quality is made, the animal is already dead. We report for the first time, a targeted next-generation sequencing (NGS) of single nucleotide polymorphisms (SNP) of lipid metabolism genes in Tattykeel Australian White (TAW) sheep of the MARGRA lamb brand, utilizing an innovative and minimally invasive muscle biopsy sampling technique for directly quantifying the genetic worth of live lambs for health-beneficial omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA), intramuscular fat (IMF), and fat melting point (FMP). NGS of stearoyl-CoA desaturase (SCD), fatty acid binding protein-4 (FABP4), and fatty acid synthase (FASN) genes identified functional SNP with unique DNA marker signatures for TAW genetics. The SCD g.23881050T>C locus was significantly associated with IMF, C22:6n-3, and C22:5n-3; FASN g.12323864A>G locus with FMP, C18:3n-3, C18:1n-9, C18:0, C16:0, MUFA, and FABP4 g.62829478A>T locus with IMF. These add new knowledge, precision, and reliability in directly making early and informed decisions on live sheep selection and breeding for health-beneficial n-3 LC-PUFA, FMP, IMF and superior meat-eating quality at the farmgate level. The findings provide evidence that significant associations exist between SNP of lipid metabolism genes and n-3 LC-PUFA, IMF, and FMP, thus underpinning potential marker-assisted selection for meat-eating quality traits in TAW lambs.

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“…Of these genes, calcium-binding protein spermatid associated 1(CABS1) and mitogen-activated protein kinase 1 (MAPK1) were those found in the selective regions of the Anhui pig population, but not in the selective regions of the Asian wild boar. The insulin-like growth factor 1 receptor (IGF1R) is widely expressed in mammals (including pigs, sheep, goats, and ducks) and is involved in growth, carcass traits, and reproductive performance ( Liu et al, 1993 ; Terman, 2011 ; Hoopes et al, 2012 ; Kijas et al, 2012 ; Zhao et al, 2018 ; Jin et al, 2020 ; Grochowska et al, 2021 ; Jiang et al, 2021 ). In female mice, IGF1R was found to play a vital role in steroidogenesis, follicle survival, and fertility ( Baumgarten et al, 2017 ), where it helped transfer nutrients to the fetus ( Hellström et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Genetic architecture and selection of Anhui autochthonous pig population revealed by whole genome resequencing

Zhang

Jiang

et al. 2022

Front. Genet.

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The genetic resources among pigs in Anhui Province are diverse, but their value and potential have yet to be discovered. To illustrate the genetic diversity and population structure of the Anhui pigs population, we resequenced the genome of 150 pigs from six representative Anhui pigs populations and analyzed this data together with the sequencing data from 40 Asian wild boars and commercial pigs. Our results showed that Anhui pigs were divided into two distinct types based on ancestral descent: Wannan Spotted pig (WSP) and Wannan Black pig (WBP) origins from the same ancestor and the other four populations origins from another ancestor. We also identified several potential selective sweep regions associated with domestication characteristics among Anhui pigs, including reproduction-associated genes (CABS1, INSL6, MAP3K12, IGF1R, INSR, LIMK2, PATZ1, MAPK1), lipid- and meat-related genes (SNX19, MSTN, MC5R, PRKG1, CREBBP, ADCY9), and ear size genes (MSRB3 and SOX5). Therefore, these findings expand the catalogue and how these genetic differences among pigs and this newly generated data will be a valuable resource for future genetic studies and for improving genome-assisted breeding of pigs and other domesticated animals.

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Association of a polymorphism in exon 3 of the IGF1R gene with growth, body size, slaughter and meat quality traits in Colored Polish Merino sheep

Cited by 9 publications

References 48 publications

Insights into the influence of diet and genetics on feed efficiency and meat production in sheep

Insights into the influence of diet and genetics on feed efficiency and meat production in sheep

Next Generation Sequencing of Single Nucleotide Polymorphic DNA-Markers in Selecting for Intramuscular Fat, Fat Melting Point, Omega-3 Long-Chain Polyunsaturated Fatty Acids and Meat Eating Quality in Tattykeel Australian White MARGRA Lamb

Genetic architecture and selection of Anhui autochthonous pig population revealed by whole genome resequencing

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