Association of APOE (E2, E3 and E4) gene variants and lipid levels in ischemic stroke, its subtypes and hemorrhagic stroke in a South Indian population

Das, Subhra; Kaul, Subhash; Jyothy, A.; Munshi, Anjana

doi:10.1016/j.neulet.2016.06.032

Cited by 16 publications

(9 citation statements)

References 39 publications

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“…The distribution of genotype frequencies of the control group was in Hardy–Weinberg equilibrium (rs7412; p = 0.36, rs429358; p = 0.93). The APOE allele frequencies in the controls ( n = 253; ε2 = 0.06; ε3 = 0.83; ε4 = 0.12) were similar to the data obtained from a study carried out by Das et al in a South Indian population ( n = 620; ε2 = 0.05; ε3 = 0.84; ε4 = 0.11; χ 2 = 0.01; df = 2; p = 0.91) [ 22 ]. In our study, there was no significant difference in APOE genotypes (χ 2 = 0.05; df = 5; p = 1) and allele frequencies (χ 2 = 0.009; df = 2; p = 0.99) between the patients and the controls.…”

Section: Resultssupporting

confidence: 85%

“…The presence of Arg112 in the APOε4 isoform led to an altered interaction between the LDL receptor-binding domain and lipid-binding domain region, which was the reason for the higher binding affinity of this isoform to VLDL [ 50 ]. In ischemic stroke patients, the ε3/ε4 genotype was associated with elevated levels of very low-density lipoprotein and triglycerides [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

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Apolipoprotein E polymorphism and the risk of aneurysmal subarachnoid hemorrhage in a South Indian population

et al. 2017

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BackgroundThe rupture of a brain aneurysm causes bleeding in the subarachnoid space. This is known as aneurysmal subarachnoid hemorrhage (aSAH). We evaluated the association of apolipoprotein E (APOE) polymorphism and the risk of aSAH in a South Indian population.MethodsThe study was performed on 200 subjects with aSAH and 253 healthy control subjects. Blood samples (5 ml) were used to isolate DNA and genotyping was performed for rs7412 and rs429358 using a Taqman allelic discrimination assay. Statistical software R.3.0.11 was used to statistically analyze the data and a p value < 0.05 was considered as statistically significant.ResultsWe found a significant association with the risk of aSAH in ε3/ ε4 genetic model (OR = 1.91, 95% CI = 1.16–3.14, p = 0.01). However, in the other genetic models and allele frequency, there was no significant association with the risk of aSAH. In subtyping, we found a significant association of ε2 allele frequency with posterior communicating artery (PCOM) aneurysm (OR = 3.59, 95% CI = 1.11–11.64, p = 0.03).ConclusionOur results suggest that APOE polymorphism has an influence on the risk of aSAH in this South Indian population, specifically in the PCOM subtype.

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Section: Resultssupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Apolipoprotein E polymorphism and the risk of aneurysmal subarachnoid hemorrhage in a South Indian population

et al. 2017

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“…ApoE ε2 is associated with lowering LDL levels and an increased reduction in LDL‐C when treated with atorvastatin in people with acute coronary syndrome . In contrast, the ε4 allele carriers are related with higher cholesterol absorption and an increased incidence of CAD or poorer response to statin treatment than ε2 or ε3 carriers . However, APOE gene polymorphism was not related to the lipid‐lowering effect of rosuvastatin in Chinese population …”

Section: Resultsmentioning

confidence: 93%

Pharmacogenetics of statins treatment: Efficacy and safety

Guan

et al. 2019

J Clin Pharm Ther

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What is known and objective: Statins are widely used worldwide in the prevention and treatment of coronary atherosclerotic heart disease and ischaemic stroke.However, in clinical application, statins have shown great individual differences in terms of the efficacy and safety, some of which are related to genetic factors. The purpose of this article was to summarize the recent advances about the correlation between gene polymorphisms and the efficacy/safety of statins. Methods:We searched the databases including PharmGKB and PubMed (published before June 2019) using the keywords such as 'statin', 'gene polymorphism' and 'SNP' and obtained more than 100 articles. In this review, we described the clinical studies of genetic variants associated with both the efficacy and adverse reactions of statins.We also clarified the importance of taking pharmacogenetic variation into account to improve the clinical application of statins. Results and discussion:The available data were collected and analysed to present the polymorphisms of candidate genes encoding the most promising proteins including SLCO1B1 (encoding uptake transporters); ABCB1, ABCC2, ABCG2 (encoding effluent transporter); APOE, APOA5 (encoding apolipoprotein); genes encoding cytochrome P450 enzyme system; KIF6, HMGCR, LDLR, LPA, PCSK9, COQ2, CETP, etc These genes were proved to be related to the pharmacodynamics and pharmacokinetics of statins, thus affecting the efficacy and safety. What is new and conclusion:In this paper, the correlation between gene polymorphisms and the efficacy/safety of statins was summarized. The authors reached a consensus that the variants of the genes encoding uptake and effluent transporters have the most effect on the efficacy/safety of statins. It pointed out that it is desirable to do genetic testing of these transporter genes to reduce the incidence of myopathy or to achieve better outcomes before patients use statins, especially in the regions with high frequency of risk allele. K E Y W O R D S cytochrome P450, gene polymorphism, pharmacogenetics, statins, transporter | 859 GUAN et Al.

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“…[ 10 ] Immune and inflammatory reactions have been shown to be important in the mechanism of cerebral ischemia injury. [ 11 ] This study was conducted to investigate the intestinal flora structure in patients with CI. We found that while the CI and healthy groups had low similarity in intestinal flora, they had similar bacterial flora.…”

Section: Discussionmentioning

confidence: 99%

The characteristics analysis of intestinal microecology on cerebral infarction patients and its correlation with apolipoprotein E

Wang¹,

Xu²,

Yao

et al. 2018

Medicine

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Cerebral infarction (CI) is associated with high rates of disability, mortality, and death in China, but its mechanism is unclear. Therefore, early diagnosis of CI and determining its mechanism are very important. Intestinal microecology is thought to be related to cardiovascular and cerebrovascular diseases. We hypothesized that intestinal microecology is also related to CI and that the intestinal microecology in the stool of CI patients differs from that in healthy people.Fecal samples of healthy subjects and CI patient (all n = 10) and we investigated the intestinal microecology of CI patient and healthy people stool by 16 seconds sequencing and analyzed relative abundance and diversity of microorganisms by unweighted pair-group method with arithmetic mean analysis (UPGMA) and principal co-ordinates analysis (PCoA). We also measured apolipoprotein E (ApoE) levels in the serum by ELISA assay and analyzed the correlation between ApoE and intestinal flora.We found that the relative structure and diversity of intestinal microecology was significantly different between the stools of CI patients and healthy people. At the class level, Gammaproteobacteria was increased and Bacteroidia was decreased in CI patient stool. We found a correlation between ApoE in the serum and Bacteroidia and Gammaproteobacteria species.We considered the intestinal flora can be used as an indicator of CI and the up-regulation of ApoE may be the potential mediate for intestinal microecology contribute to CI.

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Association of APOE (E2, E3 and E4) gene variants and lipid levels in ischemic stroke, its subtypes and hemorrhagic stroke in a South Indian population

Cited by 16 publications

References 39 publications

Apolipoprotein E polymorphism and the risk of aneurysmal subarachnoid hemorrhage in a South Indian population

Apolipoprotein E polymorphism and the risk of aneurysmal subarachnoid hemorrhage in a South Indian population

Pharmacogenetics of statins treatment: Efficacy and safety

The characteristics analysis of intestinal microecology on cerebral infarction patients and its correlation with apolipoprotein E

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