Association of Apolipoprotein A1, B with Stenosis of Intracranial and Extracranial Arteries in Patients with Cerebral Infarction

Li, Mi-Mi; Lin, You‐Yu; Huang, Yunjian; Zhuo, Shi-Tu; Yang, Mei‐Li; Lin, Huasong; Ruowei, Cai

doi:10.7754/clin.lab.2015.150419

Cited by 8 publications

(5 citation statements)

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“…APO is a type of protein that can bind to plasma lipids (mainly triglycerides, cholesterol, and phospholipids) and also plays an important role in the occurrence and development of atherosclerosis [18]. Li et al [19] studied the relationship between APO-A1, APO-B, and CIS patients with extracranial APO-A and APO-B may be the infuencing factors of MCA stenosis in CIS patients. Te ROC curve results for the Lpa, APO-A, and APO-B indices in this study showed AUC values of 0.647, 0.660, 0.672, and 0.762, respectively, both individually and in combination.…”

Section: Discussionmentioning

confidence: 99%

“…APO is a type of protein that can bind to plasma lipids (mainly triglycerides, cholesterol, and phospholipids) and also plays an important role in the occurrence and development of atherosclerosis [ 18 ]. Li et al [ 19 ] studied the relationship between APO-A1, APO-B, and CIS patients with extracranial artery stenosis and found that APO-A1 and APO-B were closely related to intracranial artery stenosis. The study by Chou et al [ 20 ] found that APO-B was a significant risk predictor of stroke.…”

Section: Discussionmentioning

confidence: 99%

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Correlation between Lpa, APO-A, APO-B, and Stenosis of Middle Cerebral Artery in Patients with Cerebral Ischemic Stroke

Chen

et al. 2022

Emergency Medicine International

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Ischemic stroke (CIS) is characterized by a high incidence, disability, and mortality. Numerous studies have demonstrated that intracranial arterial stenosis is an important pathological basis of CIS, and its main cause is atherosclerosis. Dyslipidemia is an important risk factor for atherosclerosis. Lysophosphatidic acid (Lpa), apolipoprotein -A(APO-A), and apolipoprotein -B(APO-B) proved to be significantly correlated with the severity of coronary artery disease. This study retrospectively collected the case data of 186 patients with CIS treated from May 2020 to May 2022 and explored the correlation between Lpa, APO-A, APO-B, and middle cerebral artery (MCA) stenosis in CIS patients.

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Section: Discussionmentioning

confidence: 99%

“…APO is a type of protein that can bind to plasma lipids (mainly triglycerides, cholesterol, and phospholipids) and also plays an important role in the occurrence and development of atherosclerosis [ 18 ]. Li et al [ 19 ] studied the relationship between APO-A1, APO-B, and CIS patients with extracranial artery stenosis and found that APO-A1 and APO-B were closely related to intracranial artery stenosis. The study by Chou et al [ 20 ] found that APO-B was a significant risk predictor of stroke.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Lpa, APO-A, APO-B, and Stenosis of Middle Cerebral Artery in Patients with Cerebral Ischemic Stroke

Chen

et al. 2022

Emergency Medicine International

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“…According to the research results of Li et al (2015) [ 8 ], the degree of MRI vascular stenosis was divided into 4 grades: grade 0 referred to the normal blood vessels; grade 1 indicated mild stenosis with a stenosis rate ≤ 50%; grade 2 suggested moderate and severe stenosis with a stenosis rate > 50%; and grade 3 suggested occlusion without development of distal blood vessels.…”

Section: Methodsmentioning

confidence: 99%

Magnetic resonance imaging reconstruction algorithm under complex convolutional neural network in diagnosis and prognosis of cerebral infarction

et al. 2021

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This study was to explore the application value of magnetic resonance imaging (MRI) image reconstruction model based on complex convolutional neural network (CCNN) in the diagnosis and prognosis of cerebral infarction. Two image reconstruction methods, frequency domain reconstruction network (FDRN) and image domain reconstruction network (IDRN), were introduced based on the CCNN algorithm. In addition, they were integrated to form two new MRI image reconstruction models, namely D-FDRN and D-IDRN. The peak signal to noise ratio (PSNR) value and structural similarity index measure (SSIM) value of the image were compared and analyzed before and after the integration. The MRI images of patients with cerebral infarction in the dataset were undertaken as the data source, the average diffusion coefficient (DCavg) and apparent diffusion coefficient (ADC) values of different parts of the MRI image were measured, respectively. The correlation of the vein abnormality grading (VABG) to the infarct size and the degree of stenosis of the responsible vessel was analyzed in this study. The results showed that the PSNR and SSIM values of the MRI reconstructed image of the D-IDRN algorithm based on the CCNN algorithm in this study were higher than those of other algorithms. There was a positive correlation between the VABG and the infarct size (r = 0.48 and P = 0.002), and there was a positive correlation between the VABG the degree of stenosis of the responsible vessel (r = 0.58 and P < 0.0001). The ADC value of the central area of the infarct on the affected side was significantly greatly lower than that of the normal side (P < 0.01), and the DCavg value of the central area of the infarct was much lower in contrast to the normal side (P < 0.05). It indicated that an image reconstruction algorithm constructed in this study could improve the quality of MRI images. The ADC value and DCavg value changed in the infarct central area could be used as the basis for the diagnosis of cerebral infarction. If the vein was abnormal, the patient suffered from severe vascular stenosis, large infarction area, and poorer prognosis.

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“…Also, ApoB/ apoA was closely associated with MetS. 19,24 Because MetS prevalence is lower in East Asians than in Caucasians, 48 the MetS presence alone cannot explain the high ICAS prevalence among Asians. Therefore, there may be racial differences in the component of or hostresponse to MetS.…”

Section: Mets and Related Conditionsmentioning

confidence: 99%

Location of cerebral atherosclerosis: Why is there a difference between East and West?

Kim

Ahn

et al. 2016

International Journal of Stroke

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Intracranial atherosclerosis is more prevalent in Asian patients, whereas extracranial atherosclerosis is more common in individuals from western countries. The reasons for this discrepancy remain unknown. We reviewed the relevant literature and discussed the currently available information. Although the study population, diagnostic modality, and risk factor definitions differ between studies, hypercholesterolemia is more correlated with extracranial atherosclerosis than intracranial atherosclerosis. The difference in hypercholesterolemia prevalence is one of the main reasons for racial differences. Intracranial arteries contain higher antioxidant level than extracranial arteries and may be more vulnerable to risk factors for antioxidant depletion (e.g., metabolic syndrome and diabetes mellitus). Intracranial arteries may be vulnerable to factors associated with hemodynamic stress (e.g., advanced, salt-retaining hypertension and arterial tortuosity) because of a smaller diameter, thinner media and adventitia, and fewer elastic medial fibers than extracranial arteries. Additionally, non-atherosclerotic arterial diseases (e.g., moyamoya disease) that commonly occur in the intracranial arteries of East Asians may contaminate the reports of intracranial atherosclerosis cases. Genes, including RNF 213 or those associated with high salt sensitivity, may also explain racial differences in atherosclerotic location. To understand racial differences, further well-designed studies on various risk and genetic factors should be performed in patients with cerebral atherosclerosis. Additionally, improvements in diagnostic accuracy via advancements in imaging technologies and increased genetic data will aid in the differentiation of atherosclerosis from non-atherosclerotic intracranial diseases.

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Association of Apolipoprotein A1, B with Stenosis of Intracranial and Extracranial Arteries in Patients with Cerebral Infarction

Cited by 8 publications

References 0 publications

Correlation between Lpa, APO-A, APO-B, and Stenosis of Middle Cerebral Artery in Patients with Cerebral Ischemic Stroke

Correlation between Lpa, APO-A, APO-B, and Stenosis of Middle Cerebral Artery in Patients with Cerebral Ischemic Stroke

Magnetic resonance imaging reconstruction algorithm under complex convolutional neural network in diagnosis and prognosis of cerebral infarction

Location of cerebral atherosclerosis: Why is there a difference between East and West?

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