Association of blood lead levels with preeclampsia: A cohort study in China

Wu, Su Zhen; Xu, Huan; Chen, Ying; Chen, Yu; Zhu, Qiao; Tan, Min Hua; Zhang, Miao Miao

doi:10.1016/j.envres.2021.110822

Cited by 14 publications

(7 citation statements)

References 36 publications

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“…Other pediatric disorders due to elevated lead concentrations in the mother's serum could be reduced glomerular filtration, asthma, immunological and dermatological disorders (110)(111)(112)(113). Perinatal effects of high Pb concentrations are low birth weight, preterm delivery, pre-eclampsia and pregnancy hypertension (90,(114)(115)(116)(117). Umbilical cord blood analysis has also shown that Pb affects DNA methylation and has also confirmed the reduced intellectual abilities of children coming from pregnancies with exposure to Pb (118,119).…”

Section: Discussionmentioning

confidence: 95%

Heavy metal ion concentration in the amniotic fluid of preterm and term pregnancies from two cities with different industrial output

et al. 2021

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The growth and development of the fetus is a complex phenomenon that can be influenced by several variables. High quantities of heavy metal ions in the amniotic fluid have been linked to poor health, especially in industrial, polluted and poor areas. The aim of the present study was to assess the differences in the concentration of these ions between preterm (weeks 15-37) and term pregnancies (starting at week 37). Another objective was to compare pregnancies from two cities with different industry levels. Two sample lots from two Romanian cities were analyzed. A total of 100 patients from Timisoara were compared with 60 from Petrosani, a heavy industry city in Romania. Demographic data were collected, and amniocentesis was performed on all women. Lead (Pb), copper (Cu), nickel (Ni), cadmium (Cd), arsenic (As), iron (Fe) and zinc (Zn) concentrations were assessed. Descriptive and analytical statistics were performed using the Mann-Whitney U test for non-parametric data and the Fisher's exact test for categorical data. In addition, categorical data was represented graphically. In the Timisoara cohort, the differences in heavy metal concentrations between preterm and term pregnancies were not statistically significant. In the Petrosani cohort, however, the concentrations of Zn (P=0.02606) and Cd (P=0.01512) were higher in preterm than in term pregnancies. When comparing the two cohorts as a whole, the concentration of Pb (P=0.04513), Cd (P=0.00002), As (P=0.03027) and Zn (P<0.00001) were higher in the patients from Petrosani than in those from Timisoara. Only Cu concentrations were higher in the Timisoara cohort (P<0.00001). The concentrations of Ni (P=0.78150) and Fe (P=0.44540) did not differ statistically. Thus, amniocentesis is an important diagnostic and exploratory tool in determining differences in the concentrations of elements such as heavy metal ions. Research over a longer period of time should be carried out to examine the relation between heavy metal ions concentration and possible postnatal health outcomes.

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Section: Discussionmentioning

confidence: 95%

Heavy metal ion concentration in the amniotic fluid of preterm and term pregnancies from two cities with different industrial output

et al. 2021

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“…If the lead level in the blood has exceeded 4.2 g/dl, the risk of preeclampsia increases by 105%. 14 At the end of the first trimester, lead may be detected in the fetal brain after previous passive diffusion across the placenta. During pregnancy, there is an increase in bone reabsorption, which may lead to lead exposure to the fetus.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Blood Lead Levels and Nitric Oxide (NO) Levels in Preeclampsia

Oktaviana

Yusrawati²,

Ami³

2022

Obgynia

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Objective: This study aims to determine the relationship between blood lead levels and NO levels in preeclampsia. Methods: This research applied analytical survey research with a cross-sectional design. Moreover, the samples were 99 pregnant women, 33 with normal pregnancies, 33 with preeclampsia living >10km from Semen Padang factory, and 33 with preeclampsia who lived ≤10km from Semen Padang factory. Spearman correlation test and logistic regression analysis is used for data analysis. Result: The result of this study shows that the blood lead level median in preeclampsia ≤10km is 26.23 g/dL, and the lead level median in preeclampsia >10km is 23.52 g/dL. Meanwhile, the NO level median in preeclampsia ≤10km is 22.50µmol/L and NO level median in preeclampsia >10km is 28.00µmol/L. There is a relationship between blood lead levels and NO levels in preeclampsia ≤10km, with r-value = -0.601 and p-value <0.001, in preeclampsia >10km, there is no relationship with p-value >0.500 and the strength of the correlation is fragile. In addition, the results of multivariate analysis of reduced levels of NO in preeclampsia with high blood lead levels are two times compared to preeclampsia with normal blood lead levels with 95% CI (0.652-6.362) after being controlled by distance of residence, smoking status and living environment variables. Conclusion: there is a relationship between blood lead levels and NO levels in preeclampsia.

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“…Results mean that pregnant women exposed to cigarette smoke are 3.5 times more likely to suffer from hypertension than pregnant women who are not exposed to cigarette smoke (Sibai et al, 2021). Exposure to cigarette smoke during pregnancy determines fetal growth (Wu et al, 2021). The nicotine in cigarette smoke is a vasoconstrictor substance that will cause vasoconstriction of blood vessels and increase heart contractions, increasing blood pressure in pregnant women (Wu et al, 2021).…”

Section: Figure 5 Progress Of Triglicerides Valuesmentioning

confidence: 99%

“…Exposure to cigarette smoke during pregnancy determines fetal growth (Wu et al, 2021). The nicotine in cigarette smoke is a vasoconstrictor substance that will cause vasoconstriction of blood vessels and increase heart contractions, increasing blood pressure in pregnant women (Wu et al, 2021).…”

Section: Figure 5 Progress Of Triglicerides Valuesmentioning

confidence: 99%

Nutrition Counseling, Lipid Profile Improvement and Weight Loss in Obese Patients with Dyslipidemia

Salman,

Hadi,

Ntau

et al. 2023

j. info kesehat.

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Obesity with dyslipidemia is a serious problem because it risks various degenerative and metabolic diseases. The prevalence of obesity in Indonesia continues to increase every year, currently in the adult population reaching 21.8%. To prevent the onset of degenerative diseases and metabolic disorders, it is important to control obesity with dyslipidemia through weight loss and lipid profile improvement. This study aims to determine the effect of nutritional counseling in losing weight and improving lipid profiles in obese patients with dyslipidemia. This is a pseudo-experimental study with One group Pre and Post Test Design. The initial stage was the identification of obesity and lipid profile. In 100 respondents identified as obese, total cholesterol, LDL and triglycerides were examined. 40 obese respondents with dyslipidemia were determined as samples. The second stage was nutrition counseling intervention. The third stage of evaluation is the re-measurement of body weight and lipid profile. The research result is only 30 respondents participated in the evaluation. Average initial body weight was 75.11 kg and final body weight was 73.14 kg. Average weight loss was 1.97 kg. Average initial cholesterol 233.20 mg/dL and final cholesterol 224.70 mg/dL. Average cholesterol reduction of 8.5 mg/dL. Average initial LDL 152.37 mg/dL and final LDL 139.47 mg/dL. Average decrease in LDL 12.9 mg/dL Average initial triglycerides 161.23 mg/dL and final triglycerides 143.97 mg/dL. The average decrease in triglycerides is 17.26 mg/dL. The statistical test results showed a p-value = 0.000. There is an effect of nutritional counseling on weight loss and improvement of lipid profiles of obese patients with dyslipidemia.

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Association of blood lead levels with preeclampsia: A cohort study in China

Cited by 14 publications

References 36 publications

Heavy metal ion concentration in the amniotic fluid of preterm and term pregnancies from two cities with different industrial output

Heavy metal ion concentration in the amniotic fluid of preterm and term pregnancies from two cities with different industrial output

Relationship between Blood Lead Levels and Nitric Oxide (NO) Levels in Preeclampsia

Nutrition Counseling, Lipid Profile Improvement and Weight Loss in Obese Patients with Dyslipidemia

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