Association of Blood Leukocytes and Hemoglobin with Hospital Mortality in Acute Pulmonary Embolism

Abstract

This study aimed to assess the prognostic significance of total leukocyte count (TLC) and hemoglobin (Hb) levels upon admission for patients with acute pulmonary embolism (PE), considering the European Society of Cardiology (ESC) model for mortality risk. 1622 patients from a regional PE registry were included. Decision tree statistics were employed to evaluate the prognostic value of TLC and Hb, both independently and in conjunction with the ESC model. The results indicated all-cause and PE-related in-hospital mortality rates of 10.7% and 6.5%, respectively. Subgrouping patients based on TLC cut-off values (≤11.2, 11.2–16.84, >16.84 × 109/L) revealed increasing all-cause mortality risks (7.0%, 11.8%, 30.2%). Incorporating Hb levels (≤126 g/L or above) further stratified the lowest risk group into two strata with all-cause mortality rates of 10.1% and 4.7%. Similar trends were observed for PE-related mortality. Notably, TLC improved risk assessment for intermediate–high-risk patients within the ESC model, while Hb levels enhanced mortality risk stratification for lower-risk PE patients in the ESC model for all-cause mortality. In conclusion, TLC and Hb levels upon admission can refine the ESC model’s mortality risk classification for patients with acute PE, providing valuable insights for improved patient management.

Causal association between circulating blood cell traits and pulmonary embolism: a mendelian randomization study

“…Increased neutrophil and lymphocyte counts can serve as predictors for the early development of PE in patients with COVID-2019 [ 14 ]. Total WBC counts, as well as the neutrophil/lymphocyte ratio, can aid the risk assessment of mortality in patients with acute PE [ 15 , 16 ]. Elevated WBC counts are independently associated with poor clinical outcomes in patients with central PE [ 17 ].…”