Association of body composition parameters measured on CT with risk of hospitalization in patients with Covid-19

Chandarana, Hersh; Pisuchpen, Nisanard; Krieger, Rachel; Dane, Bari; Mikheev, Artem; Feng, Yang; Kambadakone, Avinash; Rusinek, Henry

doi:10.1016/j.ejrad.2021.110031

Cited by 16 publications

(26 citation statements)

References 26 publications

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“…Skeletal muscle density can be determined, among other factors, by the amount of intramuscular fat. In fact, recently published studies have shown that the amount of intramuscular fat interferes with the prognosis of COVID-19 ( 20 , 29 , 40 ).…”

Section: Discussionmentioning

confidence: 99%

Function Over Mass: A Meta-Analysis on the Importance of Skeletal Muscle Quality in COVID-19 Patients

et al. 2022

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COVID-19 caused by SARS-CoV-2 infection is a highly contagious disease affecting both the higher and lower portions of the respiratory tract. This disease reached over 265 million people and has been responsible for over 5.25 million deaths worldwide. Skeletal muscle quality and total mass seem to be predictive of COVID-19 outcome. This systematic review aimed at providing a critical analysis of the studies published so far reporting on skeletal muscle mass in patients with COVID-19, with the intent of examining the eventual association between muscle status and disease severity. A meta-analysis was performed to evaluate whether skeletal muscle quantity, quality and function were related to disease severity. Systematic reviews and meta-analyses were conducted according to the guidelines of the Cochrane Handbook for Systematic Reviews of Interventions and reported according to the guidelines of the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guide. From a total of 1,056 references found, 480 were selected after removing duplicates. Finally, only 7 met the specified inclusion criteria. The results of this meta-analysis showed that skeletal muscle quality, rather than quantity, was associated with COVID-19 severity, as confirmed by lower skeletal muscle density and lower handgrip strength in patients with severe disease. Muscle function assessment can thus be a valuable tool with prognostic value in COVID-19.

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Section: Discussionmentioning

confidence: 99%

Function Over Mass: A Meta-Analysis on the Importance of Skeletal Muscle Quality in COVID-19 Patients

et al. 2022

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“…In CT scans, which severely ill patients frequently receive, body composition measurements at the height of the third lumbar vertebra (L3) best represent the whole-body fat and muscle mass 13 . CT body composition parameters at L3 have been found to be of predictive value in many entities including COVID-19 9 , 10 , 14 . However, most COVID-19 patients only receive chest X-rays or thoracic CT scans and while there are reviews with hundreds of studies on abdominal CT body composition measurements 15 , 16 experience on thoracic CT body composition parameters is less profound, with especially few studies on thoracic CT body composition assessment in COVID-19 5 , 6 , 17 .…”

Section: Introductionmentioning

confidence: 99%

Prediction of abdominal CT body composition parameters by thoracic measurements as a new approach to detect sarcopenia in a COVID-19 cohort

Molwitz

Ozga

Gerdes

et al. 2022

Sci Rep

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As most COVID-19 patients only receive thoracic CT scans, but body composition, which is relevant to detect sarcopenia, is determined in abdominal scans, this study aimed to investigate the relationship between thoracic and abdominal CT body composition parameters in a cohort of COVID-19 patients. This retrospective study included n = 46 SARS-CoV-2-positive patients who received CT scans of the thorax and abdomen due to severe disease progression. The subcutaneous fat area (SF), the skeletal muscle area (SMA), and the muscle radiodensity attenuation (MRA) were measured at the level of the twelfth thoracic (T12) and the third lumbar (L3) vertebra. Necessity of invasive mechanical ventilation (IMV), length of stay, or time to death (TTD) were noted. For statistics correlation, multivariable linear, logistic, and Cox regression analyses were employed. Correlation was excellent for the SF (r = 0.96) between T12 and L3, and good for the respective SMA (r = 0.80) and MRA (r = 0.82) values. With adjustment (adj.) for sex, age, and body-mass-index the variability of SF (adj. r2 = 0.93; adj. mean difference = 1.24 [95% confidence interval (95% CI) 1.02–1.45]), of the SMA (adj. r2 = 0.76; 2.59 [95% CI 1.92–3.26]), and of the MRA (adj. r2 = 0.67; 0.67 [95% CI 0.45–0.88]) at L3 was well explained by the respective values at T12. There was no relevant influence of the SF, MRA, or SMA on the clinical outcome. If only thoracic CT scans are available, CT body composition values at T12 can be used to predict abdominal fat and muscle parameters, by which sarcopenia and obesity can be assessed.

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“…The relationships between body composition abnormalities and hospitalization outcomes in patients with COVID-19 was explored in 28 studies ( 4 , 37 , 39 , 40 , 42 , 43 , 44 , 45 , 47 , 48 , 49 , 50 , 51 , 54 , 58 , 59 , 60 , 61 , 64 , 74 , 76 , 78 , 81 , 83 , 93 , 96 , 97 , 99 ) ( Figure 3 , Supplementary Table 4 ). Seven studies found that muscle mass assessed by CT ( 40 , 47 , 51 , 54 , 61 , 81 , 97 ) was inversely related to hospitalization or LOS (hospital or ICU), from a total of 19 studies ( 4 , 37 , 39 , 40 , 42 , 43 , 47 , 49 , 50 , 51 , 54 , 58 , 61 , 64 , 81 , 83 , 93 , 97 , 99 ). Using BIA, unrelated/mixed findings were shown for hospitalization in relation to FFM ( 39 , 49 , 93 ), LST ( 93 ), ALST ( 37 ) or SMI ( 93 ) in ...…”

Section: Resultsmentioning

confidence: 99%

Prevalence and clinical implications of abnormal body composition phenotypes in patients with COVID-19: a systematic review

Montes‐Ibarra

Orsso

Limon‐Miro

et al. 2023

The American Journal of Clinical Nutrition

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Association of body composition parameters measured on CT with risk of hospitalization in patients with Covid-19

Cited by 16 publications

References 26 publications

Function Over Mass: A Meta-Analysis on the Importance of Skeletal Muscle Quality in COVID-19 Patients

Function Over Mass: A Meta-Analysis on the Importance of Skeletal Muscle Quality in COVID-19 Patients

Prediction of abdominal CT body composition parameters by thoracic measurements as a new approach to detect sarcopenia in a COVID-19 cohort

Prevalence and clinical implications of abnormal body composition phenotypes in patients with COVID-19: a systematic review

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